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Overexpression of F...
Overexpression of FXYD-3 is involved in the tumorigenesis and development of esophageal squamous cell carcinoma
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Zhu, Zhen-Long (author)
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Yan, Bao-Yong (author)
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Zhang, Yu (author)
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Yang, Yan-Hong (author)
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Wang, Ming-Wei (author)
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Zentgraf, Hanswalter (author)
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Zhang, Xiang-Hong (author)
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Sun, Xiao-Feng (author)
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(publisher)
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- IOS Press 2013
- 2013
- English.
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In: Disease Markers. - 0278-0240. ; 35:3, 195-202
Abstract
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- Objective : To investigate the association of FXYD-3 expression with clinicopathological variables and PINCH in patients with ESCC. Patients and methods : Expression of FXYD-3 protein was immunohistochemically examined in normal esophageal mucous (n = 20) and ESCC (n = 64). Results : Expression of FXYD-3 in the cytoplasm markedly increased from normal esophageal epithelial cells to primary ESCC ( p = 0.001). The expression of FXYD-3 was correlated with TNM stages and depth of tumour invasion. Furthermore, the cases with lymph node metastasis tended to show a higher frequency of positive expression than those without metastasis ( p = 0.086), and FXYD-3 expression tended to be positively related to the expression of PINCH (p = 0.063). Moreover, the cases positive for both proteins had the highest frequency of lymph node metastasis (p = 0.001). However, FXYD-3 expression was not correlated with patient , s gender (p = 0.847), age (p = 0.876), tumour location (p = 0.279), size (p = 0.771) , grade of differentiation (p = 0.279), and survival (p = 0.113). Conclusion : overexpression of FXYD-3 in the cytoplasm may play an important role in the tumourigenesis and development in the human ESCC, particularly in combination with PINCH expression.
Subject headings
- Medical and Health Sciences (hsv)
- Medicin och hälsovetenskap (hsv)
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