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Attenuation of Acut...
Attenuation of Acute Pancreatitis by Peroxisome Proliferator-Activated Receptor-α in Rats: The Effect on Toll-Like Receptor Signaling Pathways
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Ding, Jun-Li (författare)
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Zhou, Zong-Guang (författare)
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Zhou, Xiang-Yu (författare)
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Zhou, Bin (författare)
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Wang, Ling (författare)
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Wang, Rong (författare)
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Zhan, Lan (författare)
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Sun, Xiao-Feng (författare)
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Li, Yuan (författare)
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- Lippincott, Williams and Wilkins 2013
- 2013
- Engelska.
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Ingår i: Pancreas. - 0885-3177. ; 42:1, 114-122
Abstract
Ämnesord
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- Objectives: The peroxisome proliferator-activated receptor-α (PPAR-α) has attracted considerable attention for its anti-inflammatory properties; however, Toll-like receptor (TLR) pathways have an essential proinflammatory role in acute pancreatitis (AP). This study aimed to evaluate the attenuation of inflammation by PPAR-α and to investigate the interaction between PPAR-α and TLR pathways in AP. Methods: Acute pancreatitis was induced in rats by administration of cerulein. The PPAR-α agonist WY14643 and/or antagonist MK886 was administered. The severity of AP was determined by measuring serum amylase, lipase, Ca 2+ , pathological changes, myeloperoxidase activity, serum levels of interleukin (IL)-6, and intercellular adhesion molecule-1 (ICAM-1). The TLR2 and TLR4 messenger RNA (mRNA) and proteins were determined by real-time reverse transcriptase polymerase chain reaction and Western blotting, respectively. The mRNA expressions of target molecules of TLR pathways, including IL-6, IL-10, ICAM-1, and tumor necrosis factor α were also measured. Results: Treatment with WY14643 significantly decreased amylase, lipase, myeloperoxidase activity, pathological scores, IL-6, and ICAM-1 levels. The TLR2 and TLR4 mRNA and proteins were markedly decreased after treatment with WY14643, along with IL-6, ICAM-1, and tumor necrosis factor α mRNA levels. However, these effects were completely reversed by the coadministration of MK886. Conclusions: Activation of PPAR-α played a protective role in AP, partially mediated by modulation of TLR pathways.
Ämnesord
- Medical and Health Sciences (hsv)
- Medicin och hälsovetenskap (hsv)
- MEDICINE (svep)
- MEDICIN (svep)
Nyckelord
- acute pancreatitis
- peroxisome proliferator-activated receptor-alpha
- Toll-like receptor
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