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On the use of the healthy lifestyle index to investigate specific disease outcomes

Viallon, Vivian (författare)
International Agency for Research On Cancer (IARC-WHO), Lyon, France
Freisling, Heinz (författare)
International Agency for Research On Cancer (IARC-WHO), Lyon, France
Matta, Komodo (författare)
International Agency for Research On Cancer (IARC-WHO), Lyon, France
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Nannsen, Anne Østergaard (författare)
Department of Public Health, Aarhus University, Aarhus, Denmark
Dahm, Christina C. (författare)
Department of Public Health, Aarhus University, Aarhus, Denmark
Tjønneland, Anne (författare)
Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, Denmark
Eriksen, Anne Kirstine (författare)
Danish Cancer Society Research Center, Copenhagen, Denmark
Kaaks, Rudolf (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Katzke, Verena A. (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Schulze, Matthias B. (författare)
Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany
Masala, Giovanna (författare)
Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy
Tagliabue, Giovanna (författare)
Cancer Registry Unit, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy
Simeon, Vittorio (författare)
Unit of Medical Statistics, University “L. Vanvitelli”, Naples, Italy
Tumino, Rosario (författare)
Hyblean Association for Epidemiological Research, AIRE–ONLUS, Ragusa, Italy
Milani, Lorenzo (författare)
Unit of Cancer Epidemiology, Città Della Salute E Della Scienza University-Hospital, and Center for Cancer Prevention (CPO), Turin, Italy
Derksen, Jeroen W. G. (författare)
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
van der Schouw, Yvonne T. (författare)
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
Nøst, Therese Haugdahl (författare)
K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU - Norwegian University of Science and Technology, Trondheim, Norway; Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway
Borch, Kristin Benjaminsen (författare)
Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway
Sandanger, Torkjel M. (författare)
Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway
Quirós, J. Ramón (författare)
Public Health Directorate, Asturias, Spain
Rodriguez-Barranco, Miguel (författare)
Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria Ibs.GRANADA, Granada, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Bonet, Catalina (författare)
Unit of Nutrition and Cancer, Catalan Institute of Oncology - ICO, L’Hospitalet de Llobregat, Barcelona, Spain; Nutrition and Cancer Group; Epidemiology, Public Health, Cancer Prevention and Palliative Care Program, Bellvitge Biomedical Research Institute - IDIBELL, L’Hospitalet de Llobregat, Barcelona, Spain
Aizpurua-Atxega, Amaia (författare)
Sub Directorate for Public Health and Addictions of Gipuzkoa, Ministry of Health of the Basque Government, San Sebastián, Spain; Epidemiology of Chronic and Communicable Diseases Group, Biodonostia Health Research Institute, San Sebastián, Spain
Cirera, Lluís (författare)
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain
Guevara, Marcela (författare)
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Instituto de Salud Pública y Laboral de Navarra, Pamplona, Spain; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain
Sundström, Björn, 1968- (författare)
Umeå universitet,Institutionen för folkhälsa och klinisk medicin
Winkvist, Anna (författare)
Umeå universitet,Avdelningen för hållbar hälsa,Department of Internal Medicine and Clinical Nutrition, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Heath, Alicia K. (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
Gunter, Marc J. (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
Weiderpass, Elisabete (författare)
International Agency for Research On Cancer (IARC-WHO), Lyon, France
Johansson, Mattias (författare)
International Agency for Research On Cancer (IARC-WHO), Lyon, France
Ferrari, Pietro (författare)
International Agency for Research On Cancer (IARC-WHO), Lyon, France
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 (creator_code:org_t)
Springer Nature, 2024
2024
Engelska.
Ingår i: Scientific Reports. - : Springer Nature. - 2045-2322. ; 14:1
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • The healthy lifestyle index (HLI), defined as the unweighted sum of individual lifestyle components, was used to investigate the combined role of lifestyle factors on health-related outcomes. We introduced weighted outcome-specific versions of the HLI, where individual lifestyle components were weighted according to their associations with disease outcomes. Within the European Prospective Investigation into Cancer and Nutrition (EPIC), we examined the association between the standard and the outcome-specific HLIs and the risk of T2D, CVD, cancer, and all-cause premature mortality. Estimates of the hazard ratios (HRs), the Harrell’s C-index and the population attributable fractions (PAFs) were compared. For T2D, the HR for 1-SD increase of the standard and T2D-specific HLI were 0.66 (95% CI: 0.64, 0.67) and 0.43 (0.42, 0.44), respectively, and the C-index were 0.63 (0.62, 0.64) and 0.72 (0.72, 0.73). Similar, yet less pronounced differences in HR and C-index were observed for standard and outcome-specific estimates for cancer, CVD and all-cause mortality. PAF estimates for mortality before age 80 were 57% (55%, 58%) and 33% (32%, 34%) for standard and mortality-specific HLI, respectively. The use of outcome-specific HLI could improve the assessment of the role of lifestyle factors on disease outcomes, thus enhancing the definition of public health recommendations.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

Nyckelord

Cancer
Cardiovascular diseases
Composite score
Healthy lifestyle index
Lifestyle factors
Mortality
Type 2 diabetes

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