Ancestry-shift refinement mapping of the C6orf97-ESR1 breast cancer susceptibility locus.

• Current attempts to identify genetic modifiers of BRCA1 and BRCA2 associated risk have focused on a candidate gene approach, based on knowledge of gene functions, or the development of large genome-wide association studies. In this study, we evaluated 24 SNPs tagged to 14 candidate genes derived through a novel approach that analysed gene expression differences to prioritise candidate modifier genes for association studies.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Adult

Aged

Aged

80 and over

Breast Neoplasms

genetics

Female

Gene Expression

Genes

BRCA2

Genetic Predisposition to Disease

Genome-Wide Association Study

Humans

Linkage Disequilibrium

Middle Aged

Mutation

Polymorphism

Single Nucleotide

Risk Factors

Signal Transduction

Smad3 Protein

genetics

Transforming Growth Factor beta

genetics

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)