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Sex-Specific Effect...
Sex-Specific Effects of Adiponectin on Carotid Intima-Media Thickness and Incident Cardiovascular Disease
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Persson, Jonas (author)
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Strawbridge, Rona J. (author)
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McLeod, Olga (author)
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Gertow, Karl (author)
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Silveira, Angela (author)
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Baldassarre, Damiano (author)
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Van Zuydam, Natalie (author)
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Shah, Sonia (author)
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Fava, Cristiano (author)
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Gustafsson, Stefan (author)
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Veglia, Fabrizio (author)
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Sennblad, Bengt (author)
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Larsson, Malin (author)
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Sabater-Lleal, Maria (author)
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Leander, Karin (author)
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Gigante, Bruna (author)
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Tabak, Adam (author)
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Kivimaki, Mika (author)
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Kauhanen, Jussi (author)
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Rauramaa, Rainer (author)
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Smit, Andries J. (author)
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Mannarino, Elmo (author)
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Giral, Philippe (author)
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Humphries, Steve E. (author)
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Tremoli, Elena (author)
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de Faire, Ulf (author)
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Lind, Lars (author)
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Ingelsson, Erik (author)
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Hedblad, Bo (author)
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Melander, Olle (author)
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Kumari, Meena (author)
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Hingorani, Aroon (author)
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Morris, Andrew D. (author)
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Palmer, Colin N. A. (author)
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Lundman, Pia (author)
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Ohrvik, John (author)
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Söderberg, Stefan (author)
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(publisher)
- 2015
- 2015
- English.
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In: Journal of the American Heart Association. - 2047-9980. ; 4 8
Abstract
Subject headings
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- Background-Plasma adiponectin levels have previously been inversely associated with carotid intima-media thickness (IMT), a marker of subclinical atherosclerosis. In this study, we used a sex-stratified Mendelian randomization approach to investigate whether adiponectin has a causal protective influence on IMT. Methods and Results-Baseline plasma adiponectin concentrationwas tested for association with baseline IMT, IMT progression over 30 months, and occurrence of cardiovascular events within 3 years in 3430 participants (women, n=1777; men, n=1653) with high cardiovascular risk but no prevalent disease. Plasma adiponectin levels were inversely associated with baseline mean bifurcation IMT after adjustment for established risk factors (beta=-0.018, P<0.001) in men but not in women (beta=-0.006, P=0.185; P for interaction=0.061). Adiponectin levels were inversely associated with progression of mean common carotid IMT in men (beta=-0.0022, P=0.047), whereas no association was seen in women (0.0007, P=0.475; P for interaction=0.018). Moreover, we observed that adiponectin levels were inversely associated with coronary events in women (hazard ratio 0.57, 95% CI 0.37 to 0.87) but not in men (hazard ratio 0.82,95% CI0.54 to 1.25). Agenescore of adiponectin-raisingalleles in6loci, reported recently inalarge multi-ethnic metaanalysis, was inversely associated with baseline mean bifurcation IMT in men (beta=-0.0008, P=0.004) but not in women (beta=-0.0003, P=0.522; P for interaction=0.007). Conclusions-This report provides some evidence for adiponectin protecting against atherosclerosis, with effects being confined to men; however, compared with established cardiovascular risk factors, the effect of plasma adiponectin was modest. Further investigation involving mechanistic studies is warranted.
Subject headings
- Medical and Health Sciences (hsv)
- Clinical Medicine (hsv)
- Cardiac and Cardiovascular Systems (hsv)
- Medicin och hälsovetenskap (hsv)
- Klinisk medicin (hsv)
- Kardiologi (hsv)
Keyword
- adiponectin
- atherosclerosis
- carotid intima-media thickness
- genetics
- Mendelian randomization
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- By the author/editor
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Persson, Jonas
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Strawbridge, Ron ...
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McLeod, Olga
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Gertow, Karl
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Silveira, Angela
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Baldassarre, Dam ...
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show more...
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Van Zuydam, Nata ...
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Shah, Sonia
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Fava, Cristiano
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Gustafsson, Stef ...
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Veglia, Fabrizio
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Sennblad, Bengt
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Larsson, Malin
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Sabater-Lleal, M ...
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Leander, Karin
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Gigante, Bruna
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Tabak, Adam
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Kivimaki, Mika
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Kauhanen, Jussi
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Rauramaa, Rainer
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Smit, Andries J.
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Mannarino, Elmo
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Giral, Philippe
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Humphries, Steve ...
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Tremoli, Elena
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de Faire, Ulf
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Lind, Lars
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Ingelsson, Erik
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Hedblad, Bo
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Melander, Olle
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Kumari, Meena
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Hingorani, Aroon
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Morris, Andrew D ...
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Palmer, Colin N. ...
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Lundman, Pia
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Ohrvik, John
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Söderberg, Stefa ...
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- By the university
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