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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03951naa a22006493a 4500 | |
| 001 | 21941060 | |
| 003 | SE-LIBR | |
| 005 | 20171116150009.0 | |
| 007 | cr|||||||||||| | |
| 008 | 171116s2017 sw |||| o |||| ||eng c | |
| 024 | 7 | a http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3329322 uri |
| 024 | 7 | a urn:nbn:se:uu:diva-3329322 urn |
| 024 | 7 | a 10.1016/j.ajpath.2017.04.0062 doi |
| 040 | a S | |
| 041 | 0 | a eng |
| 042 | 9 EPLK | |
| 100 | 1 | a Erba, Benedetta Gaia4 aut |
| 245 | 1 0 | a Endothelial-to-Mesenchymal Transition in Bone Marrow and Spleen of Primary Myelofibrosish [Elektronisk resurs] |
| 260 | c 2017 | |
| 500 | a Published | |
| 500 | a EU, Europeiska forskningsrådet [268870] | |
| 500 | a Vetenskapsrådet | |
| 500 | a Knut och Alice Wallenbergs Stiftelse | |
| 506 | 0 | a gratis |
| 520 | a Primary myelofibrosis is characterized by the development of fibrosis in the bone marrow that contributes to ineffective hematopoiesis. Bone marrow fibrosis is the result of a complex and not yet fully understood interaction among megakaryocytes, myeloid cells, fibroblasts, and endothelial cells. Here, we report that >30% of the endothelial cells in the small vessels of the bone marrow and spleen of patients with primary myelofibrosis have a mesenchymal phenotype, which is suggestive of the process known as endothelial-to-mesenchymal transition (EndMT). EndMT can be reproduced in vitro by incubation of cultured endothelial progenitor cells or spleen-derived endothelial cells with inflammatory cytokines. Megakaryocytes appear to be implicated in this process, because EndMT mainly occurs in the microvessels close to these cells, and because megakaryocyte-derived supernatant fluid can reproduce the EndMT switch in vitro. Furthermore, EndMT is an early event in a JAK2-V617F knock-in mouse model of primary myelofibrosis. Overall, these data show for the first time that microvascular endothelial cells in the bone marrow and spleen of patients with primary myelofibrosis show functional and morphologic changes that are associated to the mesenchymal phenotype. | |
| 650 | 7 | a Medical and Health Sciences2 hsv |
| 650 | 7 | a Basic Medicine2 hsv |
| 650 | 7 | a Cell and Molecular Biology2 hsv |
| 650 | 7 | a Medicin och hälsovetenskap2 hsv |
| 650 | 7 | a Medicinska och farmaceutiska grundvetenskaper2 hsv |
| 650 | 7 | a Cell- och molekylärbiologi2 hsv |
| 650 | 7 | a Medical and Health Sciences2 hsv |
| 650 | 7 | a Medical Biotechnology2 hsv |
| 650 | 7 | a Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)2 hsv |
| 650 | 7 | a Medicin och hälsovetenskap2 hsv |
| 650 | 7 | a Medicinsk bioteknologi2 hsv |
| 650 | 7 | a Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)2 hsv |
| 700 | 1 | a Gruppi, Cristian4 aut |
| 700 | 1 | a Corada, Monica4 aut |
| 700 | 1 | a Pisati, Federica4 aut |
| 700 | 1 | a Rosti, Vittorio4 aut |
| 700 | 1 | a Bartalucci, Niccolo'4 aut |
| 700 | 1 | a Villeval, Jean-Luc4 aut |
| 700 | 1 | a Vannucchi, Alessandro Maria4 aut |
| 700 | 1 | a Barosi, Giovanni4 aut |
| 700 | 1 | a Balduini, Alessandra4 aut |
| 700 | 1 | a Dejana, Elisabetta4 aut |
| 710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
| 772 | 1 8 | i channel recordw 19753896 |
| 773 | 0 8 | i Värdpublikationt American Journal of Pathologyg 187:8, 1879-1892x 0002-9440 |
| 856 | 4 0 | u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-332932 |
| 856 | 4 0 | u http://dx.doi.org/10.1016/j.ajpath.2017.04.006 |
| 856 | 4 0 | u http://uu.diva-portal.org/smash/get/diva2:1157323/FULLTEXT01 |
| 841 | 5 APISa x ab 171116||0000|||||001||||||000000e 1 | |
| 024 | 7 | 5 APISa urn:nbn:se:uu:diva-3329322 urn |
| 852 | 5 APISb APIS | |
| 856 | 4 0 | 5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-332932 |
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