Sökning: WFRF:(Bulayeva Kazima B.) > Ramasamy Adaikalavan > Novel genetic loci ...
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000 | 16525naa a22046333a 4500 | |
001 | 20118603 | |
003 | SE-LIBR | |
005 | 20170302184922.0 | |
007 | cr|||||||||||| | |
008 | 170302s2017 sw |||| o |||| ||eng c | |
024 | 7 | a http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1316392 uri |
024 | 7 | a urn:nbn:se:umu:diva-1316392 urn |
024 | 7 | a 10.1038/ncomms136242 doi |
040 | a S | |
041 | 0 | a eng |
042 | 9 EPLK | |
100 | 1 | a Hibar, Derrek P.4 aut |
245 | 1 0 | a Novel genetic loci associated with hippocampal volumeh [Elektronisk resurs] |
260 | c 2017 | |
500 | a Published | |
506 | 0 | a gratis |
520 | a The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (r(g) = -0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness. | |
650 | 7 | a Medical and Health Sciences2 hsv |
650 | 7 | a Basic Medicine2 hsv |
650 | 7 | a Medical Genetics2 hsv |
650 | 7 | a Medicin och hälsovetenskap2 hsv |
650 | 7 | a Medicinska grundvetenskaper2 hsv |
650 | 7 | a Medicinsk genetik2 hsv |
650 | 7 | a Natural Sciences2 hsv |
650 | 7 | a Biological Sciences2 hsv |
650 | 7 | a Bioinformatics and Systems Biology2 hsv |
650 | 7 | a Naturvetenskap2 hsv0 264446 |
650 | 7 | a Biologiska vetenskaper2 hsv |
650 | 7 | a Bioinformatik och systembiologi2 hsv |
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710 | 1 2 | a Umeå universitetb Medicinska fakulteten4 pbl0 268483 |
710 | 1 2 | a Umeå universitetb Medicinska fakulteten4 pbl0 268483 |
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910 | 2 s | 6 710,710a Medicinska fakulteten vid Umeå universitetu Umeå universitet.b Medicinska fakulteten |
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