Transancestral mapping and genetic load in systemic lupus erythematosus

doi:10.1038/ncomms16021

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LIBRIS Formathandbok (Information om MARC21)

Fältnamn	Indikatorer	Metadata
000		07254caa a22017533a 4500
001		21115437
003		SE-LIBR
005		20221124074654.0
007		cr \|\|\| \|\|\|\|\|
008		170815s2017 sw \|\|\|\|\|o\|\|\|\|\|000 \|\|eng\|c
024	7	a http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1380352 uri
024	7	a urn:nbn:se:umu:diva-1380352 urn
024	7	a 10.1038/ncomms160212 doi
040		a Se a
041		a eng
042		9 EPLK
100	1	a Langefeld, Carl D.4 aut
245	1 0	a Transancestral mapping and genetic load in systemic lupus erythematosush [Elektronisk resurs]
264	1	c 2017
500		a Published
506	0	a gratis
520		a Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We identify 58 distinct non-HLA regions in EA, 9 in AA and 16 in HA (similar to 50% of these regions have multiple independent associations); these include 24 novel SLE regions (P < 5 x 10(-8)), refined association signals in established regions, extended associations to additional ancestries, and a disentangled complex HLA multigenic effect. The risk allele count (genetic load) exhibits an accelerating pattern of SLE risk, leading us to posit a cumulative hit hypothesis for autoimmune disease. Comparing results across the three ancestries identifies both ancestry-dependent and ancestry-independent contributions to SLE risk. Our results are consistent with the unique and complex histories of the populations sampled, and collectively help clarify the genetic architecture and ethnic disparities in SLE.
650	7	a Medical and Health Sciences2 ssif
650	7	a Basic Medicine2 ssif
650	7	a Medical Genetics2 ssif
650	7	a Medicin och hälsovetenskap2 ssif
650	7	a Medicinska och farmaceutiska grundvetenskaper2 ssif
650	7	a Medicinsk genetik2 ssif
655	7	a government publication2 marcgt
700	1	a Ainsworth, Hannah C.4 aut
700	1	a Graham, Deborah S. Cunninghame4 aut
700	1	a Kelly, Jennifer A.4 aut
700	1	a Comeau, Mary E.4 aut
700	1	a Marion, Miranda C.4 aut
700	1	a Howard, Timothy D.4 aut
700	1	a Ramos, Paula S.4 aut
700	1	a Croker, Jennifer A.4 aut
700	1	a Morris, David L.4 aut
700	1	a Sandling, Johanna K.4 aut
700	1	a Almlof, Jonas Carlsson4 aut
700	1	a Acevedo-Vasquez, Eduardo M.4 aut
700	1	a Alarcon, Graciela S.4 aut
700	1	a Babini, Alejandra M.4 aut
700	1	a Baca, Vicente4 aut
700	1	a Bengtsson, Anders A.4 aut
700	1	a Berbotto, Guillermo A.4 aut
700	1	a Bijl, Marc4 aut
700	1	a Brown, Elizabeth E.4 aut
700	1	a Brunner, Hermine I.4 aut
700	1	a Cardiel, Mario H.4 aut
700	1	a Catoggio, Luis4 aut
700	1	a Cervera, Ricard4 aut
700	1	a Cucho-Venegas, Jorge M.4 aut
700	1	a Rantapää Dahlqvist, Solbritt4 aut
700	1	a D'Alfonso, Sandra4 aut
700	1	a Da Silva, Berta Martins4 aut
700	1	a de la Rua Figueroa, Inigo4 aut
700	1	a Doria, Andrea4 aut
700	1	a Edberg, Jeffrey C.4 aut
700	1	a Endreffy, Emoke4 aut
700	1	a Esquivel-Valerio, Jorge A.4 aut
700	1	a Fortin, Paul R.4 aut
700	1	a Freedman, Barry I.4 aut
700	1	a Frostegard, Johan4 aut
700	1	a Garcia, Mercedes A.4 aut
700	1	a Garcia de la Torre, Ignacio4 aut
700	1	a Gilkeson, Gary S.4 aut
700	1	a Gladman, Dafna D.4 aut
700	1	a Gunnarsson, Iva4 aut
700	1	a Guthridge, Joel M.4 aut
700	1	a Huggins, Jennifer L.4 aut
700	1	a James, Judith A.4 aut
700	1	a Kallenberg, Cees G. M.4 aut
700	1	a Kamen, Diane L.4 aut
700	1	a Karp, David R.4 aut
700	1	a Kaufman, Kenneth M.4 aut
700	1	a Kottyan, Leah C.4 aut
700	1	a Kovacs, Laszlo4 aut
700	1	a Laustrup, Helle4 aut
700	1	a Lauwerys, Bernard R.4 aut
700	1	a Li, Quan-Zhen4 aut
700	1	a Maradiaga-Cecena, Marco A.4 aut
700	1	a Martin, Javier4 aut
700	1	a McCune, Joseph M.4 aut
700	1	a McWilliams, David R.4 aut
700	1	a Merrill, Joan T.4 aut
700	1	a Miranda, Pedro4 aut
700	1	a Moctezuma, Jose F.4 aut
700	1	a Nath, Swapan K.4 aut
700	1	a Niewold, Timothy B.4 aut
700	1	a Orozco, Lorena4 aut
700	1	a Ortego-Centeno, Norberto4 aut
700	1	a Petri, Michelle4 aut
700	1	a Pineau, Christian A.4 aut
700	1	a Pons-Estel, Bernardo A.4 aut
700	1	a Pope, Janet4 aut
700	1	a Raj, Prithvi4 aut
700	1	a Ramsey-Goldman, Rosalind4 aut
700	1	a Reveille, John D.4 aut
700	1	a Russell, Laurie P.4 aut
700	1	a Sabio, Jose M.4 aut
700	1	a Aguilar-Salinas, Carlos A.4 aut
700	1	a Scherbarth, Hugo R.4 aut
700	1	a Scorza, Raffaella4 aut
700	1	a Seldin, Michael F.4 aut
700	1	a Sjöwall, Christopher,d 1975-4 aut0 https://libris.kb.se/zw9cgcjh2t9tlv9#it
700	1	a Svenungsson, Elisabet4 aut
700	1	a Thompson, Susan D.4 aut
700	1	a Toloza, Sergio M. A.4 aut
700	1	a Truedsson, Lennart4 aut
700	1	a Tusie-Luna, Teresa4 aut
700	1	a Vasconcelos, Carlos4 aut
700	1	a Vila, Luis M.4 aut
700	1	a Wallace, Daniel J.4 aut
700	1	a Weisman, Michael H.4 aut
700	1	a Wither, Joan E.4 aut
700	1	a Bhangale, Tushar4 aut
700	1	a Oksenberg, Jorge R.4 aut
700	1	a Rioux, John D.4 aut
700	1	a Gregersen, Peter K.4 aut
700	1	a Syvanen, Ann-Christine4 aut
700	1	a Ronnblom, Lars4 aut
700	1	a Criswell, Lindsey A.4 aut
700	1	a Jacob, Chaim O.4 aut
700	1	a Sivils, Kathy L.4 aut
700	1	a Tsao, Betty P.4 aut
700	1	a Schanberg, Laura E.4 aut
700	1	a Behrens, Timothy W.4 aut
700	1	a Silverman, Earl D.4 aut
700	1	a Alarcon-Riquelme, Marta E.4 aut
700	1	a Kimberly, Robert P.4 aut
700	1	a Harley, John B.4 aut
700	1	a Wakeland, Edward K.4 aut
700	1	a Graham, Robert R.4 aut
700	1	a Gaffney, Patrick M.4 aut
700	1	a Vyse, Timothy J.4 aut
710	1	a Umeå universitetb Medicinska fakulteten4 pbl
772	0 8	i channel recordw 18813935
773	0	t Nature Communicationsg 8x 2041-1723
856	4 0	u http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-138035
856	4 0	u http://dx.doi.org/10.1038/ncomms16021
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856	4 2	u http://www.umu.se/z web site
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887		5 APISa {"@id":"tz6gd3p01z8gpxc","modified":"2017-08-15T20:55:21+02:00"}2 librisxl

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Av författaren/redakt...: Langefeld, Carl ...; Ainsworth, Hanna ...; Graham, Deborah ...; Kelly, Jennifer ...; Comeau, Mary E.; Marion, Miranda ...; visa fler...; Howard, Timothy ...; Ramos, Paula S.; Croker, Jennifer ...; Morris, David L.; Sandling, Johann ...; Almlof, Jonas Ca ...; Acevedo-Vasquez, ...; Alarcon, Graciel ...; Babini, Alejandr ...; Baca, Vicente; Bengtsson, Ander ...; Berbotto, Guille ...; Bijl, Marc; Brown, Elizabeth ...; Brunner, Hermine ...; Cardiel, Mario H ...; Catoggio, Luis; Cervera, Ricard; Cucho-Venegas, J ...; Rantapää Dahlqvi ...; D'Alfonso, Sandr ...; Da Silva, Berta ...; de la Rua Figuer ...; Doria, Andrea; Edberg, Jeffrey ...; Endreffy, Emoke; Esquivel-Valerio ...; Fortin, Paul R.; Freedman, Barry ...; Frostegard, Joha ...; Garcia, Mercedes ...; Garcia de la Tor ...; Gilkeson, Gary S ...; Gladman, Dafna D ...; Gunnarsson, Iva; Guthridge, Joel ...; Huggins, Jennife ...; James, Judith A.; Kallenberg, Cees ...; Kamen, Diane L.; Karp, David R.; Kaufman, Kenneth ...; Kottyan, Leah C.; Kovacs, Laszlo; Laustrup, Helle; Lauwerys, Bernar ...; Li, Quan-Zhen; Maradiaga-Cecena ...; Martin, Javier; McCune, Joseph M ...; McWilliams, Davi ...; Merrill, Joan T.; Miranda, Pedro; Moctezuma, Jose ...; Nath, Swapan K.; Niewold, Timothy ...; Orozco, Lorena; Ortego-Centeno, ...; Petri, Michelle; Pineau, Christia ...; Pons-Estel, Bern ...; Pope, Janet; Raj, Prithvi; Ramsey-Goldman, ...; Reveille, John D ...; Russell, Laurie ...; Sabio, Jose M.; Aguilar-Salinas, ...; Scherbarth, Hugo ...; Scorza, Raffaell ...; Seldin, Michael ...; Sjöwall, Christo ...; Svenungsson, Eli ...; Thompson, Susan ...; Toloza, Sergio M ...; Truedsson, Lenna ...; Tusie-Luna, Tere ...; Vasconcelos, Car ...; Vila, Luis M.; Wallace, Daniel ...; Weisman, Michael ...; Wither, Joan E.; Bhangale, Tushar; Oksenberg, Jorge ...; Rioux, John D.; Gregersen, Peter ...; Syvanen, Ann-Chr ...; Ronnblom, Lars; Criswell, Lindse ...; Jacob, Chaim O.; Sivils, Kathy L.; Tsao, Betty P.; Schanberg, Laura ...; Behrens, Timothy ...; Silverman, Earl ...; Alarcon-Riquelme ...; Kimberly, Robert ...; Harley, John B.; Wakeland, Edward ...; Graham, Robert R ...; Gaffney, Patrick ...; Vyse, Timothy J.; visa färre...

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