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WFRF:(Hasvold Pal)
 

Sökning: WFRF:(Hasvold Pal) > (2016) > Association Between...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003796naa a22005413a 4500
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003SE-LIBR
00520170411151844.0
007cr||||||||||||
008170411s2016 sw |||| o |||| ||eng c
0247 a http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2814782 uri
0247 a urn:nbn:se:uu:diva-2814782 urn
0247 a 10.1007/s40261-015-0372-92 doi
040 a S
0410 a eng
042 9 EPLK
1001 a Hasvold, Pal4 aut
2451 0a Association Between Paradoxical HDL Cholesterol Decrease and Risk of Major Adverse Cardiovascular Events in Patients Initiated on Statin Treatment in a Primary Care Settingh [Elektronisk resurs]
260 c 2016
500 a Published
500 a AstraZeneca
5060 a gratis
520 a Background and Objectives Statin-induced changes in high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) are unrelated. Many patients initiated on statins experience a paradoxical decrease in HDL-C. The aim of this study was to evaluate the association between a decrease in HDL-C and risk of major adverse cardiovascular events (MACE). Methods Data from 15,357 primary care patients initiated on statins during 2004-2009 were linked with data from mandatory national hospital, drug-dispensing, and cause-of-death registers, and were grouped according to HDL-C change: decreased >= 0.1 mmol/L, unchanged +/- 0.1 or >= 0.1 mmol/L increased. To evaluate the association between decrease in HDL-C and risk of MACE, a sample of propensity score-matched patients from the decreased and unchanged groups was created, using the latter group as reference. MACE was defined as myocardial infarction, unstable angina pectoris, ischaemic stroke, or cardiovascular mortality. Cox proportional hazards models were used to estimate relative risks. Results HDL-C decreased in 20 %, was unchanged in 58%, and increased in 22 % of patients initiated on statin treatment (96 % treated with simvastatin). The propensity score-matched sample comprised 5950 patients with mean baseline HDL-C and LDL-C of 1.69 and 4.53 mmol/L, respectively. HDL-C decrease was associated with 56 % higher MACE risk (hazard ratio 1.56; 95 % confidence interval 1.12-2.16; p < 0.01) compared with the unchanged HDL-C group. Conclusions Paradoxical statin-induced reduction in HDL-C was relatively common and was associated with increased risk of MACE.
650 7a Medical and Health Sciences2 hsv
650 7a Basic Medicine2 hsv
650 7a Pharmacology and Toxicology2 hsv
650 7a Medicin och hälsovetenskap2 hsv
650 7a Medicinska grundvetenskaper2 hsv
650 7a Farmakologi och toxikologi2 hsv
7001 a Thuresson, Marcus4 aut
7001 a Sundstrom, Johan4 aut
7001 a Hammar, Niklas4 aut
7001 a Kjeldsen, Sverre E.4 aut
7001 a Johansson, Gunnar4 aut
7001 a Holme, Ingar4 aut
7001 a Bodegard, Johan4 aut
7101 2a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl
7101 2a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl
7101 2a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl
7721 8i channel recordw 19753896
7730 8i Värdpublikationt Clinical drug investigationg 36:3, 225-233x 1173-2563
8564 0u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-281478
8564 0u http://dx.doi.org/10.1007/s40261-015-0372-9
8564 0u http://uu.diva-portal.org/smash/get/diva2:915371/FULLTEXT01
841 5 APISa x ab 170411||0000|||||001||||||000000e 1
0247 5 APISa urn:nbn:se:uu:diva-2814782 urn
852 5 APISb APIS
8564 05 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-281478

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