Sökning: WFRF:(Katsoulis Michail) > Quantification of t...
Fältnamn | Indikatorer | Metadata |
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000 | 05819naa a22010333a 4500 | |
001 | 19660674 | |
003 | SE-LIBR | |
005 | 20160906175512.0 | |
007 | cr|||||||||||| | |
008 | 160906s2016 sw |||| o |||| ||eng c | |
024 | 7 | a http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1206292 uri |
024 | 7 | a urn:nbn:se:umu:diva-1206292 urn |
024 | 7 | a 10.1186/s12916-016-0607-52 doi |
040 | a S | |
041 | 0 | a eng |
042 | 9 EPLK | |
100 | 1 | a Ordóñez-Mena, José Manuel4 aut |
245 | 1 0 | a Quantification of the smoking-associated cancer risk with rate advancement periodsh [Elektronisk resurs]b meta-analysis of individual participant data from cohorts of the CHANCES consortium |
260 | c 2016 | |
500 | a Published | |
506 | 0 | a gratis |
520 | a Background: Smoking is the most important individual risk factor for many cancer sites but its association with breast and prostate cancer is not entirely clear. Rate advancement periods (RAPs) may enhance communication of smoking related risk to the general population. Thus, we estimated RAPs for the association of smoking exposure (smoking status, time since smoking cessation, smoking intensity, and duration) with total and site-specific (lung, breast, colorectal, prostate, gastric, head and neck, and pancreatic) cancer incidence and mortality. Methods : This is a meta-analysis of 19 population-based prospective cohort studies with individual participant data for 897,021 European and American adults. For each cohort we calculated hazard ratios (HRs) for the association of smoking exposure with cancer outcomes using Cox regression adjusted for a common set of the most important potential confounding variables. RAPs (in years) were calculated as the ratio of the logarithms of the HRs for a given smoking exposure variable and age. Meta-analyses were employed to summarize cohort-specific HRs and RAPs. Results : Overall, 140,205 subjects had a first incident cancer, and 53,164 died from cancer, during an average follow-up of 12 years. Current smoking advanced the overall risk of developing and dying from cancer by eight and ten years, respectively, compared with never smokers. The greatest advancements in cancer risk and mortality were seen for lung cancer and the least for breast cancer. Smoking cessation was statistically significantly associated with delays in the risk of cancer development and mortality compared with continued smoking. Conclusions: This investigation shows that smoking, even among older adults, considerably advances, and cessation delays, the risk of developing and dying from cancer. These findings may be helpful in more effectively communicating the harmful effects of smoking and the beneficial effect of smoking cessation. | |
650 | 7 | a Medical and Health Sciences2 hsv |
650 | 7 | a Health Sciences2 hsv |
650 | 7 | a Public Health, Global Health, Social Medicine and Epidemiology2 hsv |
650 | 7 | a Medicin och hälsovetenskap2 hsv |
650 | 7 | a Hälsovetenskaper2 hsv |
650 | 7 | a Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi2 hsv |
650 | 7 | a Medical and Health Sciences2 hsv |
650 | 7 | a Clinical Medicine2 hsv |
650 | 7 | a Cancer and Oncology2 hsv |
650 | 7 | a Medicin och hälsovetenskap2 hsv |
650 | 7 | a Klinisk medicin2 hsv |
650 | 7 | a Cancer och onkologi2 hsv |
653 | 0 | a Smoking |
653 | 0 | a Cancer |
653 | 0 | a Incidence |
653 | 0 | a Mortality |
653 | 0 | a Cohort |
653 | 0 | a Meta-analysis |
700 | 1 | a Schöttker, Ben4 aut |
700 | 1 | a Mons, Ute4 aut |
700 | 1 | a Jenab, Mazda4 aut |
700 | 1 | a Freisling, Heinz4 aut |
700 | 1 | a Bueno-de-Mesquita, Bas4 aut |
700 | 1 | a O'Doherty, Mark G.4 aut |
700 | 1 | a Scott, Angela4 aut |
700 | 1 | a Kee, Frank4 aut |
700 | 1 | a Stricker, Bruno H.4 aut |
700 | 1 | a Hofman, Albert4 aut |
700 | 1 | a de Keyser, Catherine E.4 aut |
700 | 1 | a Ruiter, Rikje4 aut |
700 | 1 | a Söderberg, Stefan4 aut |
700 | 1 | a Jousilahti, Pekka4 aut |
700 | 1 | a Kuulasmaa, Kari4 aut |
700 | 1 | a Freedman, Neal D.4 aut |
700 | 1 | a Wilsgaard, Tom4 aut |
700 | 1 | a de Groot, Lisette C. P. G. M.4 aut |
700 | 1 | a Kampman, Ellen4 aut |
700 | 1 | a Håkansson, Niclas4 aut |
700 | 1 | a Orsini, Nicola4 aut |
700 | 1 | a Wolk, Alicja4 aut |
700 | 1 | a Nilsson, Lena Maria4 aut |
700 | 1 | a Tjønneland, Anne4 aut |
700 | 1 | a Pająk, Andrzej4 aut |
700 | 1 | a Malyutina, Sofia4 aut |
700 | 1 | a Kubínová, Růžena4 aut |
700 | 1 | a Tamosiunas, Abdonas4 aut |
700 | 1 | a Bobak, Martin4 aut |
700 | 1 | a Katsoulis, Michail4 aut |
700 | 1 | a Orfanos, Philippos4 aut |
700 | 1 | a Boffetta, Paolo4 aut |
700 | 1 | a Trichopoulou, Antonia4 aut |
700 | 1 | a Brenner, Hermann4 aut |
710 | 1 | a Umeå universitetb Medicinska fakulteten4 pbl0 268483 |
710 | 1 | a Umeå universitetb Medicinska fakulteten4 pbl0 268483 |
710 | 1 | a Umeå universitetb Arktiskt centrum vid Umeå universitet (Arcum)4 pbl |
710 | 2 | a Heart Center4 oth |
772 | 1 8 | i channel recordw 18813935 |
773 | 0 | i Värdpublikationt BMC Medicineg 14x 1741-7015 |
856 | 4 0 | u http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-120629 |
856 | 4 0 | u http://dx.doi.org/10.1186/s12916-016-0607-5 |
856 | 4 0 | u http://umu.diva-portal.org/smash/get/diva2:953226/FULLTEXT01 |
910 | 2 s | 6 710,710a Umeå universitet.b Medicinsk-odontologiska fakultetenu Umeå universitet.b Medicinska fakulteten |
910 | 2 s | 6 710,710a Medicinska fakulteten vid Umeå universitetu Umeå universitet.b Medicinska fakulteten |
841 | 5 APISa x ab 160906||0000|||||001||||||000000e 1 | |
024 | 7 | 5 APISa urn:nbn:se:umu:diva-1206292 urn |
852 | 5 APISb APIS | |
856 | 4 0 | 5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-120629 |
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