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Circulating copper ...
Circulating copper and zinc levels and risk of hepatobiliary cancers in Europeans
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Stepien, Magdalena (author)
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Hughes, David J. (author)
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Hybsier, Sandra (author)
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Bamia, Christina (author)
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Tjønneland, Anne (author)
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Overvad, Kim (author)
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Affret, Aurélie (author)
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His, Mathilde (author)
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Boutron-Ruault, Marie-Christine (author)
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Katzke, Verena (author)
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Kuehn, Tilman (author)
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Aleksandrova, Krasimira (author)
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Trichopoulou, Antonia (author)
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Lagiou, Pagona (author)
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Orfanos, Phlippos (author)
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Palli, Domenico (author)
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Sieri, Sabina (author)
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Tumino, Rosario (author)
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Ricceri, Fulvio (author)
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Panico, Salvatore (author)
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Bueno-de-Mesquita, H. B. (as) (author)
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Peeters, Petra H. (author)
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Weiderpass, Elisabete (author)
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Lasheras, Cristina (author)
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Bonet Bonet, Catalina (author)
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Molina-Portillo, Elena (author)
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Dorronsoro, Miren (author)
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Maria Huerta, José (author)
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Barricarte, Aurelio (author)
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Ohlsson, Bodil (author)
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Sjöberg, Klas (author)
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Werner, Mårten (author)
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Shungin, Dmitry (author)
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Wareham, Nick (author)
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Khaw, Kay-Tee (author)
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Travis, Ruth C. (author)
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Freisling, Heinz (author)
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Cross, Amanda J. (author)
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Schomburg, Lutz (author)
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Jenab, Mazda (author)
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(publisher)
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(publisher)
- NATURE PUBLISHING GROUP 2017
- 2017
- English.
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In: British Journal of Cancer. - 0007-0920. ; 116:5, 688-696
Abstract
Subject headings
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- Background: Copper and zinc are essential micronutrients and cofactors of many enzymatic reactions that may be involved in liver-cancer development. We aimed to assess pre-diagnostic circulating levels of copper, zinc and their ratio (Cu/Zn) in relation to hepatocellular carcinoma (HCC), intrahepatic bile duct (IHBD) and gall bladder and biliary tract (GBTC) cancers. Methods: A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort. Serum zinc and copper levels were measured in baseline blood samples by total reflection X-ray fluorescence in cancer cases (HCC n = 106, IHDB n = 34, GBTC n = 96) and their matched controls (1: 1). The Cu/Zn ratio, an indicator of the balance between the micronutrients, was computed. Multivariable adjusted odds ratios and 95% confidence intervals (OR; 95% CI) were used to estimate cancer risk. Results: For HCC, the highest vs lowest tertile showed a strong inverse association for zinc (OR = 0.36; 95% CI: 0.13-0.98, Ptrend = 0.0123), but no association for copper (OR = 1.06; 95% CI: 0.45-2.46, Ptrend = 0.8878) in multivariable models. The calculated Cu/ Zn ratio showed a positive association for HCC (OR = 4.63; 95% CI: 1.41-15.27, Ptrend = 0.0135). For IHBC and GBTC, no significant associations were observed. Conclusions: Zinc may have a role in preventing liver-cancer development, but this finding requires further investigation in other settings.
Subject headings
- Medical and Health Sciences (hsv)
- Health Sciences (hsv)
- Public Health, Global Health, Social Medicine and Epidemiology (hsv)
- Medicin och hälsovetenskap (hsv)
- Hälsovetenskaper (hsv)
- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv)
- Medical and Health Sciences (hsv)
- Clinical Medicine (hsv)
- Cancer and Oncology (hsv)
- Medicin och hälsovetenskap (hsv)
- Klinisk medicin (hsv)
- Cancer och onkologi (hsv)
Keyword
- copper
- zinc
- hepatocellular carcinoma
- prospective cohort
- nested case-control study
- cancer risk factors
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- By the author/editor
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Stepien, Magdale ...
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Hughes, David J.
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Hybsier, Sandra
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Bamia, Christina
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Tjønneland, Anne
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Overvad, Kim
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show more...
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Affret, Aurélie
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His, Mathilde
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Boutron-Ruault, ...
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Katzke, Verena
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Kuehn, Tilman
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Aleksandrova, Kr ...
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Trichopoulou, An ...
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Lagiou, Pagona
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Orfanos, Phlippo ...
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Palli, Domenico
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Sieri, Sabina
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Tumino, Rosario
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Ricceri, Fulvio
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Panico, Salvator ...
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Bueno-de-Mesquit ...
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Peeters, Petra H ...
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Weiderpass, Elis ...
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Lasheras, Cristi ...
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Bonet Bonet, Cat ...
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Molina-Portillo, ...
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Dorronsoro, Mire ...
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Maria Huerta, Jo ...
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Barricarte, Aure ...
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Ohlsson, Bodil
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Sjöberg, Klas
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Werner, Mårten
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Shungin, Dmitry
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Wareham, Nick
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Khaw, Kay-Tee
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Travis, Ruth C.
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Freisling, Heinz
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Cross, Amanda J.
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Schomburg, Lutz
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Jenab, Mazda
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