Natriuretic peptides and integrated risk assessment for cardiovascular disease an individual-participant-data meta-analysis

doi:10.1016/S2213-8587(16)30196-6

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Sökning: WFRF:(Laukkanen Jari A.) > Nambi Vijay > Natriuretic peptide...

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Fältnamn	Indikatorer	Metadata
000		06727naa a22011053a 4500
001		20128391
003		SE-LIBR
005		20170307192929.0
007		cr\|\|\|\|\|\|\|\|\|\|\|\|
008		170307s2016 sw \|\|\|\| o \|\|\|\| \|\|eng c
024	7	a http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1321732 uri
024	7	a urn:nbn:se:umu:diva-1321732 urn
024	7	a 10.1016/S2213-8587(16)30196-62 doi
040		a S
041	0	a eng
042		9 EPLK
100	1	a Willeit, Peter4 aut
245	1 0	a Natriuretic peptides and integrated risk assessment for cardiovascular diseaseh [Elektronisk resurs]b an individual-participant-data meta-analysis
260		b Elsevierc 2016
500		a Published
506	0	a gratis
520		a Background: Guidelines for primary prevention of cardiovascular diseases focus on prediction of coronary heart disease and stroke. We assessed whether or not measurement of N-terminal-pro-B-type natriuretic peptide (NT-proBNP) concentration could enable a more integrated approach than at present by predicting heart failure and enhancing coronary heart disease and stroke risk assessment. Methods: In this individual-participant-data meta-analysis, we generated and harmonised individual-participant data from relevant prospective studies via both de-novo NT-proBNP concentration measurement of stored samples and collection of data from studies identified through a systematic search of the literature (PubMed, Scientific Citation Index Expanded, and Embase) for articles published up to Sept 4, 2014, using search terms related to natriuretic peptide family members and the primary outcomes, with no language restrictions. We calculated risk ratios and measures of risk discrimination and reclassification across predicted 10 year risk categories (ie, <5%, 5% to <7.5%, and >= 7.5%), adding assessment of NT-proBNP concentration to that of conventional risk factors (ie, age, sex, smoking status, systolic blood pressure, history of diabetes, and total and HDL cholesterol concentrations). Primary outcomes were the combination of coronary heart disease and stroke, and the combination of coronary heart disease, stroke, and heart failure. Findings: We recorded 5500 coronary heart disease, 4002 stroke, and 2212 heart failure outcomes among 95617 participants without a history of cardiovascular disease in 40 prospective studies. Risk ratios (for a comparison of the top third vs bottom third of NT-proBNP concentrations, adjusted for conventional risk factors) were 1.76 (95% CI 1.56-1.98) for the combination of coronary heart disease and stroke and 2.00 (1.77-2.26) for the combination of coronary heart disease, stroke, and heart failure. Addition of information about NT-proBNP concentration to a model containing conventional risk factors was associated with a C-index increase of 0.012 (0.010-0.014) and a net reclassification improvement of 0.027 (0.019-0.036) for the combination of coronary heart disease and stroke and a C-index increase of 0.019 (0.016-0.022) and a net reclassification improvement of 0.028 (0.019-0.038) for the combination of coronary heart disease, stroke, and heart failure. Interpretation: In people without baseline cardiovascular disease, NT-proBNP concentration assessment strongly predicted first-onset heart failure and augmented coronary heart disease and stroke prediction, suggesting that NT-proBNP concentration assessment could be used to integrate heart failure into cardiovascular disease primary prevention.
650	7	a Medical and Health Sciences2 hsv
650	7	a Clinical Medicine2 hsv
650	7	a Endocrinology and Diabetes2 hsv
650	7	a Medicin och hälsovetenskap2 hsv
650	7	a Klinisk medicin2 hsv
650	7	a Endokrinologi och diabetes2 hsv
700	1	a Kaptoge, Stephen4 aut
700	1	a Welsh, Paul4 aut
700	1	a Butterworth, Adam S.4 aut
700	1	a Chowdhury, Rajiv4 aut
700	1	a Spackman, Sarah A.4 aut
700	1	a Pennells, Lisa4 aut
700	1	a Gao, Pei4 aut
700	1	a Burgess, Stephen4 aut
700	1	a Freitag, Daniel F.4 aut
700	1	a Sweeting, Michael4 aut
700	1	a Wood, Angela M.4 aut
700	1	a Cook, Nancy R.4 aut
700	1	a Judd, Suzanne4 aut
700	1	a Trompet, Stella4 aut
700	1	a Nambi, Vijay4 aut
700	1	a Olsen, Michael Hecht4 aut
700	1	a Everett, Brendan M.4 aut
700	1	a Kee, Frank4 aut
700	1	a Arnlov, Johan4 aut
700	1	a Salomaa, Veikko4 aut
700	1	a Levy, Daniel4 aut
700	1	a Kauhanen, Jussi4 aut
700	1	a Laukkanen, Jari A.4 aut
700	1	a Kavousi, Maryam4 aut
700	1	a Ninomiya, Toshiharu4 aut
700	1	a Casas, Juan-Pablo4 aut
700	1	a Daniels, Lori B.4 aut
700	1	a Lind, Lars4 aut
700	1	a Kistorp, Caroline N.4 aut
700	1	a Rosenberg, Jens4 aut
700	1	a Mueller, Thomas4 aut
700	1	a Rubattu, Speranza4 aut
700	1	a Panagiotakos, Demosthenes B.4 aut
700	1	a Franco, Oscar H.4 aut
700	1	a de Lemos, James A.4 aut
700	1	a Luchner, Andreas4 aut
700	1	a Kizer, Jorge R.4 aut
700	1	a Kiechl, Stefan4 aut
700	1	a Salonen, Jukka T.4 aut
700	1	a Wannamethee, S. Goya4 aut
700	1	a de Boer, Rudolf A.4 aut
700	1	a Nordestgaard, Borge G.4 aut
700	1	a Andersson, Jonas4 aut
700	1	a Jorgensen, Torben4 aut
700	1	a Melander, Olle4 aut
700	1	a Ballantyne, Christie M.4 aut
700	1	a DeFilippi, Christopher4 aut
700	1	a Ridker, Paul M.4 aut
700	1	a Cushman, Mary4 aut
700	1	a Rosamond, Wayne D.4 aut
700	1	a Thompson, Simon G.4 aut
700	1	a Gudnason, Vilmundur4 aut
700	1	a Sattar, Naveed4 aut
700	1	a Danesh, John4 aut
700	1	a Di Angelantonio, Emanuele4 aut
710	1 2	a Umeå universitetb Medicinska fakulteten4 pbl0 268483
772	1 8	i channel recordw 18813935
773	0 8	i Värdpublikationt The Lancet Diabetes and Endocrinologyg 4:10, 840-849x 2213-8587
856	4 0	u http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-132173
856	4 0	u http://dx.doi.org/10.1016/S2213-8587(16)30196-6
856	4 0	u http://umu.diva-portal.org/smash/get/diva2:1078760/FULLTEXT01
910	2 s	6 710a Umeå universitet.b Medicinsk-odontologiska fakultetenu Umeå universitet.b Medicinska fakulteten
910	2 s	6 710a Medicinska fakulteten vid Umeå universitetu Umeå universitet.b Medicinska fakulteten
841		5 APISa x ab 170307\|\|0000\|\|\|\|\|001\|\|\|\|\|\|000000e 1
024	7	5 APISa urn:nbn:se:umu:diva-1321732 urn
852		5 APISb APIS
856	4 0	5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-132173

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Av författaren/redakt...: Willeit, Peter; Kaptoge, Stephen; Welsh, Paul; Butterworth, Ada ...; Chowdhury, Rajiv; Spackman, Sarah ...; visa fler...; Pennells, Lisa; Gao, Pei; Burgess, Stephen; Freitag, Daniel ...; Sweeting, Michae ...; Wood, Angela M.; Cook, Nancy R.; Judd, Suzanne; Trompet, Stella; Nambi, Vijay; Olsen, Michael H ...; Everett, Brendan ...; Kee, Frank; Arnlov, Johan; Salomaa, Veikko; Levy, Daniel; Kauhanen, Jussi; Laukkanen, Jari ...; Kavousi, Maryam; Ninomiya, Toshih ...; Casas, Juan-Pabl ...; Daniels, Lori B.; Lind, Lars; Kistorp, Carolin ...; Rosenberg, Jens; Mueller, Thomas; Rubattu, Speranz ...; Panagiotakos, De ...; Franco, Oscar H.; de Lemos, James ...; Luchner, Andreas; Kizer, Jorge R.; Kiechl, Stefan; Salonen, Jukka T ...; Wannamethee, S. ...; de Boer, Rudolf ...; Nordestgaard, Bo ...; Andersson, Jonas; Jorgensen, Torbe ...; Melander, Olle; Ballantyne, Chri ...; DeFilippi, Chris ...; Ridker, Paul M.; Cushman, Mary; Rosamond, Wayne ...; Thompson, Simon ...; Gudnason, Vilmun ...; Sattar, Naveed; Danesh, John; Di Angelantonio, ...; visa färre...

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