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Sökning: WFRF:(Rolandsson Olov) > Dahlin Lars B > Gottsater Anders > Temporal trend of a...
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Temporal trend of autonomic nerve function and HSP27, MIF and PAI-1 in type 1 diabetes
- Zimmerman, Malin (författare)
- Enes, Sara Rolandsson (författare)
- Skarstrand, Hanna (författare)
- visa fler...
- Pourhamidi, Kaveh (författare)
- Gottsater, Anders (författare)
- Wollmer, Per (författare)
- Rolandsson, Olov (författare)
- Westergren-Thorsson, Gunilla (författare)
- Dahlin, Lars B. (författare)
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- (utgivare)
- 2017
- 2017
- Engelska.
- Ingår i: ; 8, 15-21
- swepub:Mat__t
Abstract
Ämnesord
Stäng
- Aim: Diabetes mellitus type 1 (T1D) has numerous complications including autonomic neuropathy, i.e. dysfunction of the autonomous nervous system. This study focuses on Heat Shock Protein 27 (HSP27), Macrophage Migration Inhibitory Factor (MIF), Plasminogen Activator Inhibitor-1 (PAI-1) and HbA1c and their possible roles in effects of diabetes on the autonomic nervous system. Methods: Patients with T1D (n = 32, 41% women) were recruited in 1985 and followed up on four occasions (1989, 1993, 1998, and 2005). Autonomic function was tested using expiration/inspiration (E/I-ratio). Blood samples, i.e . HSP27 (last three occasions), MIF, PAI-1 (last two occasions) and HbA1c (five occasions), were analyzed. Results: Autonomic nerve function deteriorated over time during the 20-year-period, but levels of HSP27, MIF, and PAI-1 were not associated with cardiovascular autonomic neuropathy. MIF and PAI-1 were lower in T1D than in healthy controls in 2005. Increased HbA1c correlated with a decrease in E/I-ratio. Conclusions: Neither the neuroprotective substance HSP27 nor the inflammatory substances, MIF and PAI-1 were associated with measures of cardiovascular autonomic nerve function, but a deterioration of such function was observed in relation to increasing HbA1c in T1D during a 20-year follow-up period. Improved glucose control might be associated with protection against autonomic neuropathy in T1D.
Ämnesord
- Medical and Health Sciences (hsv)
- Clinical Medicine (hsv)
- Endocrinology and Diabetes (hsv)
- Medicin och hälsovetenskap (hsv)
- Klinisk medicin (hsv)
- Endokrinologi och diabetes (hsv)
Nyckelord
- Type 1 diabetes mellitus
- Diabetic autonomic neuropathy
- Heat-Shock Protein 27
- Macrophage gration Inhibition Factors
- PAI-1
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