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No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis
- Loley, Christina (author)
- Alver, Maris (author)
- Assimes, Themistocles L. (author)
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- Bjonnes, Andrew (author)
- Goel, Anuj (author)
- Gustafsson, Stefan (author)
- Hernesniemi, Jussi (author)
- Hopewell, Jemma C. (author)
- Kanoni, Stavroula (author)
- Kleber, Marcus E. (author)
- Lau, King Wai (author)
- Lu, Yingchang (author)
- Lyytikainen, Leo-Pekka (author)
- Nelson, Christopher P. (author)
- Nikpay, Majid (author)
- Qu, Liming (author)
- Salfati, Elias (author)
- Scholz, Markus (author)
- Tukiainen, Taru (author)
- Willenborg, Christina (author)
- Won, Hong-Hee (author)
- Zeng, Lingyao (author)
- Zhang, Weihua (author)
- Anand, Sonia S. (author)
- Beutner, Frank (author)
- Bottinger, Erwin P. (author)
- Clarke, Robert (author)
- Dedoussis, George (author)
- Do, Ron (author)
- Esko, Tonu (author)
- Eskola, Markku (author)
- Farrall, Martin (author)
- Gauguier, Dominique (author)
- Giedraitis, Vilmantas (author)
- Granger, Christopher B. (author)
- Hall, Alistair S. (author)
- Hamsten, Anders (author)
- Hazen, Stanley L. (author)
- Huang, Jie (author)
- Kahonen, Mika (author)
- Kyriakou, Theodosios (author)
- Laaksonen, Reijo (author)
- Lind, Lars (author)
- Lindgren, Cecilia (author)
- Magnusson, Patrik K. E. (author)
- Marouli, Eirini (author)
- Mihailov, Evelin (author)
- Morris, Andrew P. (author)
- Nikus, Kjell (author)
- Pedersen, Nancy (author)
- Rallidis, Loukianos (author)
- Salomaa, Veikko (author)
- Shah, Svati H. (author)
- Stewart, Alexandre F. R. (author)
- Thompson, John R. (author)
- Zalloua, Pierre A. (author)
- Chambers, John C. (author)
- Collins, Rory (author)
- Ingelsson, Erik (author)
- Iribarren, Carlos (author)
- Karhunen, Pekka J. (author)
- Kooner, Jaspal S. (author)
- Lehtimaki, Terho (author)
- Loos, Ruth J. F. (author)
- Maerz, Winfried (author)
- McPherson, Ruth (author)
- Metspalu, Andres (author)
- Reilly, Muredach P. (author)
- Ripatti, Samuli (author)
- Sanghera, Dharambir K. (author)
- Thiery, Joachim (author)
- Watkins, Hugh (author)
- Deloukas, Panos (author)
- Kathiresan, Sekar (author)
- Samani, Nilesh J. (author)
- Schunkert, Heribert (author)
- Erdmann, Jeanette (author)
- Koenig, Inke R. (author)
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- 2016
- 2016
- English.
- In: Scientific Reports. - 2045-2322. ; 6
- swepub:Mat__t
Abstract
Subject headings
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- In recent years, genome-wide association studies have identified 58 independent risk loci for coronary artery disease (CAD) on the autosome. However, due to the sex-specific data structure of the X chromosome, it has been excluded from most of these analyses. While females have 2 copies of chromosome X, males have only one. Also, one of the female X chromosomes may be inactivated. Therefore, special test statistics and quality control procedures are required. Thus, little is known about the role of X-chromosomal variants in CAD. To fill this gap, we conducted a comprehensive X-chromosome-wide meta-analysis including more than 43,000 CAD cases and 58,000 controls from 35 international study cohorts. For quality control, sex-specific filters were used to adequately take the special structure of X-chromosomal data into account. For single study analyses, several logistic regression models were calculated allowing for inactivation of one female X-chromosome, adjusting for sex and investigating interactions between sex and genetic variants. Then, meta-analyses including all 35 studies were conducted using random effects models. None of the investigated models revealed genome-wide significant associations for any variant. Although we analyzed the largest-to-date sample, currently available methods were not able to detect any associations of X-chromosomal variants with CAD.
Subject headings
- Medical and Health Sciences (hsv)
- Basic Medicine (hsv)
- Medical Genetics (hsv)
- Medicin och hälsovetenskap (hsv)
- Medicinska grundvetenskaper (hsv)
- Medicinsk genetik (hsv)
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- Loley, Christina
- Alver, Maris
- Assimes, Themist ...
- Bjonnes, Andrew
- Goel, Anuj
- Gustafsson, Stef ...
- show more...
- Hernesniemi, Jus ...
- Hopewell, Jemma ...
- Kanoni, Stavroul ...
- Kleber, Marcus E ...
- Lau, King Wai
- Lu, Yingchang
- Lyytikainen, Leo ...
- Nelson, Christop ...
- Nikpay, Majid
- Qu, Liming
- Salfati, Elias
- Scholz, Markus
- Tukiainen, Taru
- Willenborg, Chri ...
- Won, Hong-Hee
- Zeng, Lingyao
- Zhang, Weihua
- Anand, Sonia S.
- Beutner, Frank
- Bottinger, Erwin ...
- Clarke, Robert
- Dedoussis, Georg ...
- Do, Ron
- Esko, Tonu
- Eskola, Markku
- Farrall, Martin
- Gauguier, Domini ...
- Giedraitis, Vilm ...
- Granger, Christo ...
- Hall, Alistair S ...
- Hamsten, Anders
- Hazen, Stanley L ...
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- Kahonen, Mika
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- Laaksonen, Reijo
- Lind, Lars
- Lindgren, Cecili ...
- Magnusson, Patri ...
- Marouli, Eirini
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- Morris, Andrew P ...
- Nikus, Kjell
- Pedersen, Nancy
- Rallidis, Loukia ...
- Salomaa, Veikko
- Shah, Svati H.
- Stewart, Alexand ...
- Thompson, John R ...
- Zalloua, Pierre ...
- Chambers, John C ...
- Collins, Rory
- Ingelsson, Erik
- Iribarren, Carlo ...
- Karhunen, Pekka ...
- Kooner, Jaspal S ...
- Lehtimaki, Terho
- Loos, Ruth J. F.
- Maerz, Winfried
- McPherson, Ruth
- Metspalu, Andres
- Reilly, Muredach ...
- Ripatti, Samuli
- Sanghera, Dharam ...
- Thiery, Joachim
- Watkins, Hugh
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- Schunkert, Herib ...
- Erdmann, Jeanett ...
- Koenig, Inke R.
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