WFRF:(Yamamoto Ken)
Sökning: WFRF:(Yamamoto Ken) > (2016) > Genome-wide associa...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05632naa a22013693a 4500 | |
| 001 | 19660363 | |
| 003 | SE-LIBR | |
| 005 | 20160906170934.0 | |
| 007 | cr|||||||||||| | |
| 008 | 160906s2016 sw |||| o |||| ||eng c | |
| 024 | 7 | a http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1160732 uri |
| 024 | 7 | a urn:nbn:se:umu:diva-1160732 urn |
| 024 | 7 | a 10.1038/srep179582 doi |
| 040 | a S | |
| 041 | 0 | a eng |
| 042 | 9 EPLK | |
| 100 | 1 | a Wen, Wanqing4 aut |
| 245 | 1 0 | a Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumferenceh [Elektronisk resurs] |
| 260 | c 2016 | |
| 500 | a Published | |
| 506 | 0 | a gratis |
| 520 | a Sixty genetic loci associated with abdominal obesity, measured by waist circumference (WC) and waist-hip ratio (WHR), have been previously identified, primarily from studies conducted in Europeanancestry populations. We conducted a meta-analysis of associations of abdominal obesity with approximately 2.5 million single nucleotide polymorphisms (SNPs) among 53,052 (for WC) and 48,312 (for WHR) individuals of Asian descent, and replicated 33 selected SNPs among 3,762 to 17,110 additional individuals. We identified four novel loci near the EFEMP1, ADAMTSL3, CNPY2, and GNAS genes that were associated with WC after adjustment for body mass index (BMI); two loci near the NID2 and HLA-DRB5 genes associated with WHR after adjustment for BMI, and three loci near the CEP120, TSC22D2, and SLC22A2 genes associated with WC without adjustment for BMI. Functional enrichment analyses revealed enrichment of corticotropin-releasing hormone signaling, GNRH signaling, and/or CDK5 signaling pathways for those newly-identified loci. Our study provides additional insight on genetic contribution to abdominal obesity. | |
| 650 | 7 | a Medical and Health Sciences2 hsv |
| 650 | 7 | a Health Sciences2 hsv |
| 650 | 7 | a Public Health, Global Health, Social Medicine and Epidemiology2 hsv |
| 650 | 7 | a Medicin och hälsovetenskap2 hsv |
| 650 | 7 | a Hälsovetenskaper2 hsv |
| 650 | 7 | a Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi2 hsv |
| 653 | 0 | a genetic loci |
| 653 | 0 | a abdominal obesity |
| 700 | 1 | a Kato, Norihiro4 aut |
| 700 | 1 | a Hwang, Joo-Yeon4 aut |
| 700 | 1 | a Guo, Xingyi4 aut |
| 700 | 1 | a Tabara, Yasuharu4 aut |
| 700 | 1 | a Li, Huaixing4 aut |
| 700 | 1 | a Dorajoo, Rajkumar4 aut |
| 700 | 1 | a Yang, Xiaobo4 aut |
| 700 | 1 | a Tsai, Fuu-Jen4 aut |
| 700 | 1 | a Li, Shengxu4 aut |
| 700 | 1 | a Wu, Ying4 aut |
| 700 | 1 | a Wu, Tangchun4 aut |
| 700 | 1 | a Kim, Soriul4 aut |
| 700 | 1 | a Guo, Xiuqing4 aut |
| 700 | 1 | a Liang, Jun4 aut |
| 700 | 1 | a Shungin, Dmitry4 aut |
| 700 | 1 | a Adair, Linda S.4 aut |
| 700 | 1 | a Akiyama, Koichi4 aut |
| 700 | 1 | a Allison, Matthew4 aut |
| 700 | 1 | a Cai, Qiuyin4 aut |
| 700 | 1 | a Chang, Li-Ching4 aut |
| 700 | 1 | a Chen, Chien-Hsiun4 aut |
| 700 | 1 | a Chen, Yuan-Tsong4 aut |
| 700 | 1 | a Cho, Yoon Shin4 aut |
| 700 | 1 | a Choi, Bo Youl4 aut |
| 700 | 1 | a Gao, Yutang4 aut |
| 700 | 1 | a Go, Min Jin4 aut |
| 700 | 1 | a Gu, Dongfeng4 aut |
| 700 | 1 | a Han, Bok-Ghee4 aut |
| 700 | 1 | a He, Meian4 aut |
| 700 | 1 | a Hixson, James E.4 aut |
| 700 | 1 | a Hu, Yanling4 aut |
| 700 | 1 | a Huang, Tao4 aut |
| 700 | 1 | a Isono, Masato4 aut |
| 700 | 1 | a Jung, Keum Ji4 aut |
| 700 | 1 | a Kang, Daehee4 aut |
| 700 | 1 | a Kim, Young Jin4 aut |
| 700 | 1 | a Kita, Yoshikuni4 aut |
| 700 | 1 | a Lee, Juyoung4 aut |
| 700 | 1 | a Lee, Nanette R.4 aut |
| 700 | 1 | a Lee, Jeannette4 aut |
| 700 | 1 | a Wang, Yiqin4 aut |
| 700 | 1 | a Liu, Jian-Jun4 aut |
| 700 | 1 | a Long, Jirong4 aut |
| 700 | 1 | a Moon, Sanghoon4 aut |
| 700 | 1 | a Nakamura, Yasuyuki4 aut |
| 700 | 1 | a Nakatochi, Masahiro4 aut |
| 700 | 1 | a Ohnaka, Keizo4 aut |
| 700 | 1 | a Rao, Dabeeru4 aut |
| 700 | 1 | a Shi, Jiajun4 aut |
| 700 | 1 | a Sull, Jae Woong4 aut |
| 700 | 1 | a Tan, Aihua4 aut |
| 700 | 1 | a Ueshima, Hirotsugu4 aut |
| 700 | 1 | a Wu, Chen4 aut |
| 700 | 1 | a Xiang, Yong-Bing4 aut |
| 700 | 1 | a Yamamoto, Ken4 aut |
| 700 | 1 | a Yao, Jie4 aut |
| 700 | 1 | a Ye, Xingwang4 aut |
| 700 | 1 | a Yokota, Mitsuhiro4 aut |
| 700 | 1 | a Zhang, Xiaomin4 aut |
| 700 | 1 | a Zheng, Yan4 aut |
| 700 | 1 | a Qi, Lu4 aut |
| 700 | 1 | a Rotter, Jerome I.4 aut |
| 700 | 1 | a Jee, Sun Ha4 aut |
| 700 | 1 | a Lin, Dongxin4 aut |
| 700 | 1 | a Mohlke, Karen L.4 aut |
| 700 | 1 | a He, Jiang4 aut |
| 700 | 1 | a Mo, Zengnan4 aut |
| 700 | 1 | a Wu, Jer-Yuarn4 aut |
| 700 | 1 | a Tai, E. Shyong4 aut |
| 700 | 1 | a Lin, Xu4 aut |
| 700 | 1 | a Miki, Tetsuro4 aut |
| 700 | 1 | a Kim, Bong-Jo4 aut |
| 700 | 1 | a Takeuchi, Fumihiko4 aut |
| 700 | 1 | a Zheng, Wei4 aut |
| 700 | 1 | a Shu, Xiao-Ou4 aut |
| 710 | 1 | a Umeå universitetb Medicinska fakulteten4 pbl0 268483 |
| 772 | 1 8 | i channel recordw 18813935 |
| 773 | 0 | i Värdpublikationt Scientific Reportsg 6x 2045-2322 |
| 856 | 4 0 | u http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-116073 |
| 856 | 4 0 | u http://dx.doi.org/10.1038/srep17958 |
| 856 | 4 0 | u http://umu.diva-portal.org/smash/get/diva2:902258/FULLTEXT01 |
| 910 | 2 s | 6 710a Umeå universitet.b Medicinsk-odontologiska fakultetenu Umeå universitet.b Medicinska fakulteten |
| 910 | 2 s | 6 710a Medicinska fakulteten vid Umeå universitetu Umeå universitet.b Medicinska fakulteten |
| 841 | 5 APISa x ab 160906||0000|||||001||||||000000e 1 | |
| 024 | 7 | 5 APISa urn:nbn:se:umu:diva-1160732 urn |
| 852 | 5 APISb APIS | |
| 856 | 4 0 | 5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-116073 |
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- Adair, Linda S.
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- Cho, Yoon Shin
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- Hixson, James E.
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- Huang, Tao
- Isono, Masato
- Jung, Keum Ji
- Kang, Daehee
- Kim, Young Jin
- Kita, Yoshikuni
- Lee, Juyoung
- Lee, Nanette R.
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