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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 13637naa a22034693a 4500 | |
| 001 | 20161354 | |
| 003 | SE-LIBR | |
| 005 | 20170315161214.0 | |
| 007 | cr|||||||||||| | |
| 008 | 170315s2016 sw |||| o |||| ||eng c | |
| 024 | 7 | a http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1287572 uri |
| 024 | 7 | a urn:nbn:se:liu:diva-1287572 urn |
| 024 | 7 | a 10.1038/ncomms113752 doi |
| 040 | a S | |
| 041 | 0 | a eng |
| 042 | 9 EPLK | |
| 100 | 1 | a Couch, Fergus J.4 aut |
| 245 | 1 0 | a Identification of four novel susceptibility loci for oestrogen receptor negative breast cancerh [Elektronisk resurs] |
| 260 | b NATURE PUBLISHING GROUPc 2016 | |
| 500 | a <p>Funding Agencies|European Community Seventh Framework Programme [223175, HEALTH-F2-2009-223175]; Cancer Research UK [C1287/A10118, C1287/A10710, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692, C12292/A11174]; National Institutes of Health [CA116201, CA128978, CA176785, CA192393]; National Institutes of Health, Post-Cancer GWAS initiative [1U19 CA148537, 1U19 CA148065, 1U19 CA148112]; National Institutes of Health, GAME-ON initiative; Canadian Institutes of Health Research (CIHR); Breast Cancer Res. Foundation; Ovarian Cancer Research Fund; Department of Defence [W81XWH-10-1-0341]; Florida Breast Cancer Foundation</p> | |
| 500 | a Published | |
| 506 | 0 | a gratis |
| 520 | a Common variants in 94 loci have been associated with breast cancer including 15 loci with genome-wide significant associations (P&lt;5 x 10(-8)) with oestrogen receptor (ER)-negative breast cancer and BRCA1-associated breast cancer risk. In this study, to identify new ER-negative susceptibility loci, we performed a meta-analysis of 11 genome-wide association studies (GWAS) consisting of 4,939 ER-negative cases and 14,352 controls, combined with 7,333 ER-negative cases and 42,468 controls and 15,252 BRCA1 mutation carriers genotyped on the iCOGS array. We identify four previously unidentified loci including two loci at 13q22 near KLF5, a 2p23.2 locus near WDR43 and a 2q33 locus near PPIL3 that display genome-wide significant associations with ER-negative breast cancer. In addition, 19 known breast cancer risk loci have genome-wide significant associations and 40 had moderate associations (P&lt;0.05) with ER-negative disease. Using functional and eQTL studies we implicate TRMT61B and WDR43 at 2p23.2 and PPIL3 at 2q33 in ER-negative breast cancer aetiology. All ER-negative loci combined account for similar to 11% of familial relative risk for ER-negative disease and may contribute to improved ER-negative and BRCA1 breast cancer risk prediction. | |
| 650 | 7 | a Medical and Health Sciences2 hsv |
| 650 | 7 | a Clinical Medicine2 hsv |
| 650 | 7 | a Cancer and Oncology2 hsv |
| 650 | 7 | a Medicin och hälsovetenskap2 hsv |
| 650 | 7 | a Klinisk medicin2 hsv |
| 650 | 7 | a Cancer och onkologi2 hsv |
| 700 | 1 | a Kuchenbaecker, Karoline B.4 aut |
| 700 | 1 | a Michailidou, Kyriaki4 aut |
| 700 | 1 | a Mendoza-Fandino, Gustavo A.4 aut |
| 700 | 1 | a Nord, Silje4 aut |
| 700 | 1 | a Lilyquist, Janna4 aut |
| 700 | 1 | a Olswold, Curtis4 aut |
| 700 | 1 | a Hallberg, Emily4 aut |
| 700 | 1 | a Agata, Simona4 aut |
| 700 | 1 | a Ahsan, Habibul4 aut |
| 700 | 1 | a Aittomaeki, Kristiina4 aut |
| 700 | 1 | a Ambrosone, Christine4 aut |
| 700 | 1 | a Andrulis, Irene L.4 aut |
| 700 | 1 | a Anton-Culver, Hoda4 aut |
| 700 | 1 | a Arndt, Volker4 aut |
| 700 | 1 | a Arun, Banu K.4 aut |
| 700 | 1 | a Arver, Brita4 aut |
| 700 | 1 | a Barile, Monica4 aut |
| 700 | 1 | a Barkardottir, Rosa B.4 aut |
| 700 | 1 | a Barrowdale, Daniel4 aut |
| 700 | 1 | a Beckmann, Lars4 aut |
| 700 | 1 | a Beckmann, Matthias W.4 aut |
| 700 | 1 | a Benitez, Javier4 aut |
| 700 | 1 | a Blank, Stephanie V.4 aut |
| 700 | 1 | a Blomqvist, Carl4 aut |
| 700 | 1 | a Bogdanova, Natalia V.4 aut |
| 700 | 1 | a Bojesen, Stig E.4 aut |
| 700 | 1 | a Bolla, Manjeet K.4 aut |
| 700 | 1 | a Bonanni, Bernardo4 aut |
| 700 | 1 | a Brauch, Hiltrud4 aut |
| 700 | 1 | a Brenner, Hermann4 aut |
| 700 | 1 | a Burwinkel, Barbara4 aut |
| 700 | 1 | a Buys, Saundra S.4 aut |
| 700 | 1 | a Caldes, Trinidad4 aut |
| 700 | 1 | a Caligo, Maria A.4 aut |
| 700 | 1 | a Canzian, Federico4 aut |
| 700 | 1 | a Carpenter, Jane4 aut |
| 700 | 1 | a Chang-Claude, Jenny4 aut |
| 700 | 1 | a Chanock, Stephen J.4 aut |
| 700 | 1 | a Chung, Wendy K.4 aut |
| 700 | 1 | a Claes, Kathleen B. M.4 aut |
| 700 | 1 | a Cox, Angela4 aut |
| 700 | 1 | a Cross, Simon S.4 aut |
| 700 | 1 | a Cunningham, Julie M.4 aut |
| 700 | 1 | a Czene, Kamila4 aut |
| 700 | 1 | a Daly, Mary B.4 aut |
| 700 | 1 | a Damiola, Francesca4 aut |
| 700 | 1 | a Darabi, Hatef4 aut |
| 700 | 1 | a de la Hoya, Miguel4 aut |
| 700 | 1 | a Devilee, Peter4 aut |
| 700 | 1 | a Diez, Orland4 aut |
| 700 | 1 | a Ding, Yuan C.4 aut |
| 700 | 1 | a Dolcetti, Riccardo4 aut |
| 700 | 1 | a Domchek, Susan M.4 aut |
| 700 | 1 | a Dorfling, Cecilia M.4 aut |
| 700 | 1 | a dos-Santos-Silva, Isabel4 aut |
| 700 | 1 | a Dumont, Martine4 aut |
| 700 | 1 | a Dunning, Alison M.4 aut |
| 700 | 1 | a Eccles, Diana M.4 aut |
| 700 | 1 | a Ehrencrona, Hans4 aut |
| 700 | 1 | a Ekici, Arif B.4 aut |
| 700 | 1 | a Eliassen, Heather4 aut |
| 700 | 1 | a Ellis, Steve4 aut |
| 700 | 1 | a Fasching, Peter A.4 aut |
| 700 | 1 | a Figueroa, Jonine4 aut |
| 700 | 1 | a Flesch-Janys, Dieter4 aut |
| 700 | 1 | a Foersti, Asta4 aut |
| 700 | 1 | a Fostira, Florentia4 aut |
| 700 | 1 | a Foulkes, William D.4 aut |
| 700 | 1 | a Friebel, Tara4 aut |
| 700 | 1 | a Friedman, Eitan4 aut |
| 700 | 1 | a Frost, Debra4 aut |
| 700 | 1 | a Gabrielson, Marike4 aut |
| 700 | 1 | a Gammon, Marilie D.4 aut |
| 700 | 1 | a Ganz, Patricia A.4 aut |
| 700 | 1 | a Gapstur, Susan M.4 aut |
| 700 | 1 | a Garber, Judy4 aut |
| 700 | 1 | a Gaudet, Mia M.4 aut |
| 700 | 1 | a Gayther, Simon A.4 aut |
| 700 | 1 | a Gerdes, Anne-Marie4 aut |
| 700 | 1 | a Ghoussaini, Maya4 aut |
| 700 | 1 | a Giles, Graham G.4 aut |
| 700 | 1 | a Glendon, Gord4 aut |
| 700 | 1 | a Godwin, Andrew K.4 aut |
| 700 | 1 | a Goldberg, Mark S.4 aut |
| 700 | 1 | a Goldgar, David E.4 aut |
| 700 | 1 | a Gonzalez-Neira, Anna4 aut |
| 700 | 1 | a Greene, Mark H.4 aut |
| 700 | 1 | a Gronwald, Jacek4 aut |
| 700 | 1 | a Guenel, Pascal4 aut |
| 700 | 1 | a Gunter, Marc4 aut |
| 700 | 1 | a Haeberle, Lothar4 aut |
| 700 | 1 | a Haiman, Christopher A.4 aut |
| 700 | 1 | a Hamann, Ute4 aut |
| 700 | 1 | a Hansen, Thomas V. O.4 aut |
| 700 | 1 | a Hart, Steven4 aut |
| 700 | 1 | a Healey, Sue4 aut |
| 700 | 1 | a Heikkinen, Tuomas4 aut |
| 700 | 1 | a Henderson, Brian E.4 aut |
| 700 | 1 | a Herzog, Josef4 aut |
| 700 | 1 | a Hogervorst, Frans B. L.4 aut |
| 700 | 1 | a Hollestelle, Antoinette4 aut |
| 700 | 1 | a Hooning, Maartje J.4 aut |
| 700 | 1 | a Hoover, Robert N.4 aut |
| 700 | 1 | a Hopper, John L.4 aut |
| 700 | 1 | a Humphreys, Keith4 aut |
| 700 | 1 | a Hunter, David J.4 aut |
| 700 | 1 | a Huzarski, Tomasz4 aut |
| 700 | 1 | a Imyanitov, Evgeny N.4 aut |
| 700 | 1 | a Isaacs, Claudine4 aut |
| 700 | 1 | a Jakubowska, Anna4 aut |
| 700 | 1 | a James, Paul4 aut |
| 700 | 1 | a Janavicius, Ramunas4 aut |
| 700 | 1 | a Birk Jensen, Uffe4 aut |
| 700 | 1 | a John, Esther M.4 aut |
| 700 | 1 | a Jones, Michael4 aut |
| 700 | 1 | a Kabisch, Maria4 aut |
| 700 | 1 | a Kar, Siddhartha4 aut |
| 700 | 1 | a Karlan, Beth Y.4 aut |
| 700 | 1 | a Khan, Sofia4 aut |
| 700 | 1 | a Khaw, Kay-Tee4 aut |
| 700 | 1 | a Kibriya, Muhammad G.4 aut |
| 700 | 1 | a Knight, Julia A.4 aut |
| 700 | 1 | a Ko, Yon-Dschun4 aut |
| 700 | 1 | a Konstantopoulou, Irene4 aut |
| 700 | 1 | a Kosma, Veli-Matti4 aut |
| 700 | 1 | a Kristensen, Vessela4 aut |
| 700 | 1 | a Kwong, Ava4 aut |
| 700 | 1 | a Laitman, Yael4 aut |
| 700 | 1 | a Lambrechts, Diether4 aut |
| 700 | 1 | a Lazaro, Conxi4 aut |
| 700 | 1 | a Lee, Eunjung4 aut |
| 700 | 1 | a Le Marchand, Loic4 aut |
| 700 | 1 | a Lester, Jenny4 aut |
| 700 | 1 | a Lindblom, Annika4 aut |
| 700 | 1 | a Lindor, Noralane4 aut |
| 700 | 1 | a Lindstrom, Sara4 aut |
| 700 | 1 | a Liu, Jianjun4 aut |
| 700 | 1 | a Long, Jirong4 aut |
| 700 | 1 | a Lubinski, Jan4 aut |
| 700 | 1 | a Mai, Phuong L.4 aut |
| 700 | 1 | a Makalic, Enes4 aut |
| 700 | 1 | a Malone, Kathleen E.4 aut |
| 700 | 1 | a Mannermaa, Arto4 aut |
| 700 | 1 | a Manoukian, Siranoush4 aut |
| 700 | 1 | a Margolin, Sara4 aut |
| 700 | 1 | a Marme, Frederik4 aut |
| 700 | 1 | a Martens, John W. M.4 aut |
| 700 | 1 | a McGuffog, Lesley4 aut |
| 700 | 1 | a Meindl, Alfons4 aut |
| 700 | 1 | a Miller, Austin4 aut |
| 700 | 1 | a Milne, Roger L.4 aut |
| 700 | 1 | a Miron, Penelope4 aut |
| 700 | 1 | a Montagna, Marco4 aut |
| 700 | 1 | a Mazoyer, Sylvie4 aut |
| 700 | 1 | a Mulligan, Anna M.4 aut |
| 700 | 1 | a Muranen, Taru A.4 aut |
| 700 | 1 | a Nathanson, Katherine L.4 aut |
| 700 | 1 | a Neuhausen, Susan L.4 aut |
| 700 | 1 | a Nevanlinna, Heli4 aut |
| 700 | 1 | a Nordestgaard, Borge G.4 aut |
| 700 | 1 | a Nussbaum, Robert L.4 aut |
| 700 | 1 | a Offit, Kenneth4 aut |
| 700 | 1 | a Olah, Edith4 aut |
| 700 | 1 | a Olopade, Olufunmilayo I.4 aut |
| 700 | 1 | a Olson, Janet E.4 aut |
| 700 | 1 | a Osorio, Ana4 aut |
| 700 | 1 | a Park, Sue K.4 aut |
| 700 | 1 | a Peeters, Petra H.4 aut |
| 700 | 1 | a Peissel, Bernard4 aut |
| 700 | 1 | a Peterlongo, Paolo4 aut |
| 700 | 1 | a Peto, Julian4 aut |
| 700 | 1 | a Phelan, Catherine M.4 aut |
| 700 | 1 | a Pilarski, Robert4 aut |
| 700 | 1 | a Poppe, Bruce4 aut |
| 700 | 1 | a Pylkaes, Katri4 aut |
| 700 | 1 | a Radice, Paolo4 aut |
| 700 | 1 | a Rahman, Nazneen4 aut |
| 700 | 1 | a Rantala, Johanna4 aut |
| 700 | 1 | a Rappaport, Christine4 aut |
| 700 | 1 | a Rennert, Gad4 aut |
| 700 | 1 | a Richardson, Andrea4 aut |
| 700 | 1 | a Robson, Mark4 aut |
| 700 | 1 | a Romieu, Isabelle4 aut |
| 700 | 1 | a Rudolph, Anja4 aut |
| 700 | 1 | a Rutgers, Emiel J.4 aut |
| 700 | 1 | a Sanchez, Maria-Jose4 aut |
| 700 | 1 | a Santella, Regina M.4 aut |
| 700 | 1 | a Sawyer, Elinor J.4 aut |
| 700 | 1 | a Schmidt, Daniel F.4 aut |
| 700 | 1 | a Schmidt, Marjanka K.4 aut |
| 700 | 1 | a Schmutzler, Rita K.4 aut |
| 700 | 1 | a Schumacher, Fredrick4 aut |
| 700 | 1 | a Scott, Rodney4 aut |
| 700 | 1 | a Senter, Leigha4 aut |
| 700 | 1 | a Sharma, Priyanka4 aut |
| 700 | 1 | a Simard, Jacques4 aut |
| 700 | 1 | a Singer, Christian F.4 aut |
| 700 | 1 | a Sinilnikova, Olga M.4 aut |
| 700 | 1 | a Soucy, Penny4 aut |
| 700 | 1 | a Southey, Melissa4 aut |
| 700 | 1 | a Steinemann, Doris4 aut |
| 700 | 1 | a Stenmark-Askmalm, Marie4 aut |
| 700 | 1 | a Stoppa-Lyonnet, Dominique4 aut |
| 700 | 1 | a Swerdlow, Anthony4 aut |
| 700 | 1 | a Szabo, Csilla I.4 aut |
| 700 | 1 | a Tamimi, Rulla4 aut |
| 700 | 1 | a Tapper, William4 aut |
| 700 | 1 | a Teixeira, Manuel R.4 aut |
| 700 | 1 | a Teo, Soo-Hwang4 aut |
| 700 | 1 | a Terry, Mary B.4 aut |
| 700 | 1 | a Thomassen, Mads4 aut |
| 700 | 1 | a Thompson, Deborah4 aut |
| 700 | 1 | a Tihomirova, Laima4 aut |
| 700 | 1 | a Toland, Amanda E.4 aut |
| 700 | 1 | a Tollenaar, Robert A. E. M.4 aut |
| 700 | 1 | a Tomlinson, Ian4 aut |
| 700 | 1 | a Truong, Therese4 aut |
| 700 | 1 | a Tsimiklis, Helen4 aut |
| 700 | 1 | a Teule, Alex4 aut |
| 700 | 1 | a Tumino, Rosario4 aut |
| 700 | 1 | a Tung, Nadine4 aut |
| 700 | 1 | a Turnbull, Clare4 aut |
| 700 | 1 | a Ursin, Giski4 aut |
| 700 | 1 | a van Deurzen, Carolien H. M.4 aut |
| 700 | 1 | a van Rensburg, Elizabeth J.4 aut |
| 700 | 1 | a Varon-Mateeva, Raymonda4 aut |
| 700 | 1 | a Wang, Zhaoming4 aut |
| 700 | 1 | a Wang-Gohrke, Shan4 aut |
| 700 | 1 | a Weiderpass, Elisabete4 aut |
| 700 | 1 | a Weitzel, Jeffrey N.4 aut |
| 700 | 1 | a Whittemore, Alice4 aut |
| 700 | 1 | a Wildiers, Hans4 aut |
| 700 | 1 | a Winqvist, Robert4 aut |
| 700 | 1 | a Yang, Xiaohong R.4 aut |
| 700 | 1 | a Yannoukakos, Drakoulis4 aut |
| 700 | 1 | a Yao, Song4 aut |
| 700 | 1 | a Pilar Zamora, M.4 aut |
| 700 | 1 | a Zheng, Wei4 aut |
| 700 | 1 | a Hall, Per4 aut |
| 700 | 1 | a Kraft, Peter4 aut |
| 700 | 1 | a Vachon, Celine4 aut |
| 700 | 1 | a Slager, Susan4 aut |
| 700 | 1 | a Chenevix-Trench, Georgia4 aut |
| 700 | 1 | a Pharoah, Paul D. P.4 aut |
| 700 | 1 | a Monteiro, Alvaro A. N.4 aut |
| 700 | 1 | a Garcia-Closas, Montserrat4 aut |
| 700 | 1 | a Easton, Douglas F.4 aut |
| 700 | 1 | a Antoniou, Antonis C.4 aut |
| 710 | 1 2 | a Linköpings universitetb Institutionen för klinisk och experimentell medicin4 pbl0 347333 |
| 710 | 1 2 | a Linköpings universitetb Medicinska fakulteten4 pbl |
| 710 | 1 2 | a Region Östergötlandb Diagnostikcentrum4 pbl |
| 772 | 1 8 | i channel recordw 18478042 |
| 773 | 0 8 | i Värdpublikationt Nature Communicationsg 7:11375, 1-13x 2041-1723 |
| 856 | 4 0 | u http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-128757 |
| 856 | 4 0 | u http://dx.doi.org/10.1038/ncomms11375 |
| 856 | 4 0 | u http://liu.diva-portal.org/smash/get/diva2:931925/FULLTEXT01 |
| 910 | 2 s | 6 710a IKEu Linköpings universitet.b Institutionen för klinisk och experimentell medicin |
| 910 | 2 s | 6 710a Linköping University.b Department of Clinical and Experimental Medicineu Linköpings universitet.b Institutionen för klinisk och experimentell medicin |
| 910 | 2 s | 6 710a Linköping University.b Faculty of Health Sciences.b Department of Clinical and Experimental Medicineu Linköpings universitet.b Institutionen för klinisk och experimentell medicin |
| 841 | 5 APISa x ab 170315||0000|||||001||||||000000e 1 | |
| 024 | 7 | 5 APISa urn:nbn:se:liu:diva-1287572 urn |
| 852 | 5 APISb APIS | |
| 856 | 4 0 | 5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-128757 |
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