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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 07512naa a22011773a 4500 | |
| 001 | 20193107 | |
| 003 | SE-LIBR | |
| 005 | 20170323165536.0 | |
| 007 | cr|||||||||||| | |
| 008 | 170323s2016 sw |||| o |||| ||eng c | |
| 024 | 7 | a http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2930222 uri |
| 024 | 7 | a urn:nbn:se:uu:diva-2930222 urn |
| 024 | 7 | a 10.1038/ng.35262 doi |
| 040 | a S | |
| 041 | 0 | a eng |
| 042 | 9 EPLK | |
| 100 | 1 | a Braasch, Ingo4 aut |
| 245 | 1 0 | a The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisonsh [Elektronisk resurs] |
| 260 | c 2016 | |
| 500 | a <p>Funding: We thank the Broad Institute Genomics Platform for constructing and sequencing gar DNA and RNA libraries and J. Turner-Maier for the gar transcriptome assembly. We thank the teams of the Bayousphere Research Laboratory (Nicholls State University) and the University of Oregon Fish Facility for gar work and husbandry. We thank J. Westlund for the design of the species illustrations. The generation of gar sequences and assemblies by the Broad Institute of MIT and Harvard University was supported by US National Institutes of Health (NIH)/National Human Genome Research Institute grant U54 HG03067. This work was further supported by US NIH grants R01 OD011116 (alias R01 RR020833) and R24 OD01119004 (J.H.P.); a Feodor Lynen Fellowship from the Alexander von Humboldt Foundation and the Volkswagen Foundation Initiative Evolutionary Biology, grant I/84 815 (I.B.); US NIH grant T32 HD055164 and National Science Foundation (NSF) Doctoral Dissertation Improvement Grant 1311436 (A.R.G.); Uehara Memorial Foundation Research Fellowship 2013, Japan Society for the Promotion of Science Postdoctoral Research Fellowship 2012-127 and Marine Biological Laboratory Research Award 2014 (T.N.); Brazilian National Council for Scientific and Technological Development (CNPq) grants 402754/2012-3 and 477658/2012-1 (I.S.); the Brinson Foundation and the University of Chicago Biological Sciences Division (N.H.S.); NSF grant BCS0725227 (K.K.); call 'ARISTEIA I' of the National Strategic Reference Framework 2007-2013 (SPARCOMP, 36), Ministry of Education and Religious Affairs of Greece (T.M.); Agence Nationale de la Recherche (ANR) grant ANR-10-GENM-017 (PhyloFish; J.B.); the Wellcome Trust (grants WT095908 and WT098051) and the European Molecular Biology Laboratory (D.B., S.M.J.S. and B.A.); the Biomedical Research Council of the Agency for Science, Technology and Research (A*STAR), Singapore (B.V.); European Research Council grant 268513 (P.W.H.H. and K.J.M.); the Ministerio de Ciencia e Innovacion (BFU2010-14875 and BFU2015-71340) and the Generalitat de Catalunya, AGAUR (SGR2014-290) (C. C.); US NIH grant R01 AI057559 (G.W.L. and J.A.Y.); US NIH grants R24 OD010922 and R01 GM079492 (C. T. A.); and the National Basic Research Program of China (973 Program) (2012CB947600) and the National Natural Science Foundation of China (NSFC) (31030062) (H.W.).</p> | |
| 500 | a Published | |
| 506 | 0 | a gratis |
| 520 | a To connect human biology to fish biomedical models, we sequenced the genome of spotted gar (Lepisosteus oculatus), whose lineage diverged from teleosts before teleost genome duplication (TGD). The slowly evolving gar genome has conserved in content and size many entire chromosomes from bony vertebrate ancestors. Gar bridges teleosts to tetrapods by illuminating the evolution of immunity, mineralization and development (mediated, for example, by Hox, ParaHox and microRNA genes). Numerous conserved noncoding elements (CNEs; often cis regulatory) undetectable in direct human-teleost comparisons become apparent using gar: functional studies uncovered conserved roles for such cryptic CNEs, facilitating annotation of sequences identified in human genome-wide association studies. Transcriptomic analyses showed that the sums of expression domains and expression levels for duplicated teleost genes often approximate the patterns and levels of expression for gar genes, consistent with subfunctionalization. The gar genome provides a resource for understanding evolution after genome duplication, the origin of vertebrate genomes and the function of human regulatory sequences. | |
| 650 | 7 | a Medical and Health Sciences2 hsv |
| 650 | 7 | a Basic Medicine2 hsv |
| 650 | 7 | a Medical Genetics2 hsv |
| 650 | 7 | a Medicin och hälsovetenskap2 hsv |
| 650 | 7 | a Medicinska grundvetenskaper2 hsv |
| 650 | 7 | a Medicinsk genetik2 hsv |
| 700 | 1 | a Gehrke, Andrew R.4 aut |
| 700 | 1 | a Smith, Jeramiah J.4 aut |
| 700 | 1 | a Kawasaki, Kazuhiko4 aut |
| 700 | 1 | a Manousaki, Tereza4 aut |
| 700 | 1 | a Pasquier, Jeremy4 aut |
| 700 | 1 | a Amores, Angel4 aut |
| 700 | 1 | a Desvignes, Thomas4 aut |
| 700 | 1 | a Batzel, Peter4 aut |
| 700 | 1 | a Catchen, Julian4 aut |
| 700 | 1 | a Berlin, Aaron M.4 aut |
| 700 | 1 | a Campbell, Michael S.4 aut |
| 700 | 1 | a Barrell, Daniel4 aut |
| 700 | 1 | a Martin, Kyle J.4 aut |
| 700 | 1 | a Mulley, John F.4 aut |
| 700 | 1 | a Ravi, Vydianathan4 aut |
| 700 | 1 | a Lee, Alison P.4 aut |
| 700 | 1 | a Nakamura, Tetsuya4 aut |
| 700 | 1 | a Chalopin, Domitille4 aut |
| 700 | 1 | a Fan, Shaohua4 aut |
| 700 | 1 | a Wcisel, Dustin4 aut |
| 700 | 1 | a Canestro, Cristian4 aut |
| 700 | 1 | a Sydes, Jason4 aut |
| 700 | 1 | a Beaudry, Felix E. G.4 aut |
| 700 | 1 | a Sun, Yi4 aut |
| 700 | 1 | a Hertel, Jana4 aut |
| 700 | 1 | a Beam, Michael J.4 aut |
| 700 | 1 | a Fasold, Mario4 aut |
| 700 | 1 | a Ishiyama, Mikio4 aut |
| 700 | 1 | a Johnson, Jeremy4 aut |
| 700 | 1 | a Kehr, Steffi4 aut |
| 700 | 1 | a Lara, Marcia4 aut |
| 700 | 1 | a Letaw, John H.4 aut |
| 700 | 1 | a Litman, Gary W.4 aut |
| 700 | 1 | a Litman, Ronda T.4 aut |
| 700 | 1 | a Mikami, Masato4 aut |
| 700 | 1 | a Ota, Tatsuya4 aut |
| 700 | 1 | a Saha, Nil Ratan4 aut |
| 700 | 1 | a Williams, Louise4 aut |
| 700 | 1 | a Stadler, Peter F.4 aut |
| 700 | 1 | a Wang, Han4 aut |
| 700 | 1 | a Taylor, John S.4 aut |
| 700 | 1 | a Fontenot, Quenton4 aut |
| 700 | 1 | a Ferrara, Allyse4 aut |
| 700 | 1 | a Searle, Stephen M. J.4 aut |
| 700 | 1 | a Aken, Bronwen4 aut |
| 700 | 1 | a Yandell, Mark4 aut |
| 700 | 1 | a Schneider, Igor4 aut |
| 700 | 1 | a Yoder, Jeffrey A.4 aut |
| 700 | 1 | a Volff, Jean-Nicolas4 aut |
| 700 | 1 | a Meyer, Axel4 aut |
| 700 | 1 | a Amemiya, Chris T.4 aut |
| 700 | 1 | a Venkatesh, Byrappa4 aut |
| 700 | 1 | a Holland, Peter W. H.4 aut |
| 700 | 1 | a Guiguen, Yann4 aut |
| 700 | 1 | a Bobe, Julien4 aut |
| 700 | 1 | a Shubin, Neil H.4 aut |
| 700 | 1 | a Di Palma, Federica4 aut |
| 700 | 1 | a Alfoeldi, Jessica4 aut |
| 700 | 1 | a Lindblad-Toh, Kerstin4 aut0 268427 |
| 700 | 1 | a Postlethwait, John H.4 aut |
| 710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
| 710 | 1 2 | a Uppsala universitetb Science for Life Laboratory, SciLifeLab4 pbl |
| 772 | 1 8 | i channel recordw 19753896 |
| 773 | 0 8 | i Värdpublikationt Nature Geneticsg 48:4, 427-437x 1061-4036 |
| 856 | 4 0 | u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-293022 |
| 856 | 4 0 | u http://dx.doi.org/10.1038/ng.3526 |
| 856 | 4 0 | u http://uu.diva-portal.org/smash/get/diva2:927223/FULLTEXT01 |
| 900 | 1 s | 6 700a Toh, Kerstin Lindblad-u Lindblad-Toh, Kerstin |
| 841 | 5 APISa x ab 170323||0000|||||001||||||000000e 1 | |
| 024 | 7 | 5 APISa urn:nbn:se:uu:diva-2930222 urn |
| 852 | 5 APISb APIS | |
| 856 | 4 0 | 5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-293022 |
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