Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria a literature review and meta-analysis of individual patient data

doi:10.1186/s12916-015-0445-x

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Fältnamn	Indikatorer	Metadata
000		10179naa a22022573a 4500
001		20193961
003		SE-LIBR
005		20170323175406.0
007		cr\|\|\|\|\|\|\|\|\|\|\|\|
008		170323s2015 sw \|\|\|\| o \|\|\|\| \|\|eng c
024	7	a http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2659562 uri
024	7	a urn:nbn:se:uu:diva-2659562 urn
024	7	a 10.1186/s12916-015-0445-x2 doi
040		a S
041	0	a eng
042		9 EPLK
100	1	a Abdulla, Salim4 aut
245	1 0	a Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malariah [Elektronisk resurs]b a literature review and meta-analysis of individual patient data
260		c 2015
500		a Published
506	0	a gratis
520		a Background: Artemisinin-resistant Plasmodium falciparum has emerged in the Greater Mekong sub-region and poses a major global public health threat. Slow parasite clearance is a key clinical manifestation of reduced susceptibility to artemisinin. This study was designed to establish the baseline values for clearance in patients from Sub-Saharan African countries with uncomplicated malaria treated with artemisinin-based combination therapies (ACTs). Methods: A literature review in PubMed was conducted in March 2013 to identify all prospective clinical trials (uncontrolled trials, controlled trials and randomized controlled trials), including ACTs conducted in Sub-Saharan Africa, between 1960 and 2012. Individual patient data from these studies were shared with the WorldWide Antimalarial Resistance Network (WWARN) and pooled using an a priori statistical analytical plan. Factors affecting early parasitological response were investigated using logistic regression with study sites fitted as a random effect. The risk of bias in included studies was evaluated based on study design, methodology and missing data. Results: In total, 29,493 patients from 84 clinical trials were included in the analysis, treated with artemether-lumefantrine (n = 13,664), artesunate-amodiaquine (n = 11,337) and dihydroartemisinin-piperaquine (n = 4,492). The overall parasite clearance rate was rapid. The parasite positivity rate (PPR) decreased from 59.7 % (95 % CI: 54.5-64.9) on day 1 to 6.7 % (95 % CI: 4.8-8.7) on day 2 and 0.9 % (95 % CI: 0.5-1.2) on day 3. The 95th percentile of observed day 3 PPR was 5.3 %. Independent risk factors predictive of day 3 positivity were: high baseline parasitaemia (adjusted odds ratio (AOR) = 1.16 (95 % CI: 1.08-1.25); per 2-fold increase in parasite density, P <0.001); fever (>37.5 degrees C) (AOR = 1.50 (95 % CI: 1.06-2.13), P = 0.022); severe anaemia (AOR = 2.04 (95 % CI: 1.21-3.44), P = 0.008); areas of low/moderate transmission setting (AOR = 2.71 (95 % CI: 1.38-5.36), P = 0.004); and treatment with the loose formulation of artesunate-amodiaquine (AOR = 2.27 (95 % CI: 1.14-4.51), P = 0.020, compared to dihydroartemisinin-piperaquine). Conclusions: The three ACTs assessed in this analysis continue to achieve rapid early parasitological clearance across the sites assessed in Sub-Saharan Africa. A threshold of 5 % day 3 parasite positivity from a minimum sample size of 50 patients provides a more sensitive benchmark in Sub-Saharan Africa compared to the current recommended threshold of 10 % to trigger further investigation of artemisinin susceptibility.
650	7	a Medical and Health Sciences2 hsv
650	7	a Clinical Medicine2 hsv
650	7	a Infectious Medicine2 hsv
650	7	a Medicin och hälsovetenskap2 hsv
650	7	a Klinisk medicin2 hsv
650	7	a Infektionsmedicin2 hsv
700	1	a Adam, Ishag4 aut
700	1	a Adjei, George O.4 aut
700	1	a Adjuik, Martin A.4 aut
700	1	a Alemayehu, Bereket4 aut
700	1	a Allan, Richard4 aut
700	1	a Arinaitwe, Emmanuel4 aut
700	1	a Ashley, Elizabeth A.4 aut
700	1	a Ba, Mamadou S.4 aut
700	1	a Barennes, Hubert4 aut
700	1	a Barnes, Karen I.4 aut
700	1	a Bassat, Quique4 aut
700	1	a Baudin, Elisabeth4 aut
700	1	a Berens-Riha, Nicole4 aut
700	1	a Bjoerkman, Anders4 aut
700	1	a Bompart, Francois4 aut
700	1	a Bonnet, Maryline4 aut
700	1	a Borrmann, Steffen4 aut
700	1	a Bousema, Teun4 aut
700	1	a Brasseur, Philippe4 aut
700	1	a Bukirwa, Hasifa4 aut
700	1	a Checchi, Francesco4 aut
700	1	a Dahal, Prabin4 aut
700	1	a D'Alessandro, Umberto4 aut
700	1	a Desai, Meghna4 aut
700	1	a Dicko, Alassane4 aut
700	1	a Djimde, Abdoulaye A.4 aut
700	1	a Dorsey, Grant4 aut
700	1	a Doumbo, Ogobara K.4 aut
700	1	a Drakeley, Chris J.4 aut
700	1	a Duparc, Stephan4 aut
700	1	a Eshetu, Teferi4 aut
700	1	a Espie, Emmanuelle4 aut
700	1	a Etard, Jean-Francois4 aut
700	1	a Faiz, Abul M.4 aut
700	1	a Falade, Catherine O.4 aut
700	1	a Fanello, Caterina I.4 aut
700	1	a Faucher, Jean-Francois4 aut
700	1	a Faye, Babacar4 aut
700	1	a Faye, Oumar4 aut
700	1	a Filler, Scott4 aut
700	1	a Flegg, Jennifer A.4 aut
700	1	a Fofana, Bakary4 aut
700	1	a Fogg, Carole4 aut
700	1	a Gadalla, Nahla B.4 aut
700	1	a Gaye, Oumar4 aut
700	1	a Genton, Blaise4 aut
700	1	a Gething, Peter W.4 aut
700	1	a Gil, Jose P.4 aut
700	1	a Gonzalez, Raquel4 aut
700	1	a Grandesso, Francesco4 aut
700	1	a Greenhouse, Bryan4 aut
700	1	a Greenwood, Brian4 aut0 57188
700	1	a Grivoyannis, Anastasia4 aut
700	1	a Guerin, Philippe J.4 aut
700	1	a Guthmann, Jean-Paul4 aut
700	1	a Hamed, Kamal4 aut
700	1	a Hamour, Sally4 aut
700	1	a Hay, Simon I.4 aut
700	1	a Hodel, Eva Maria4 aut
700	1	a Humphreys, Georgina S.4 aut
700	1	a Hwang, Jimee4 aut
700	1	a Ibrahim, Maman L.4 aut
700	1	a Jima, Daddi4 aut
700	1	a Jones, Joel J.4 aut
700	1	a Jullien, Vincent4 aut
700	1	a Juma, Elizabeth4 aut
700	1	a Kachur, Patrick S.4 aut
700	1	a Kager, Piet A.4 aut
700	1	a Kamugisha, Erasmus4 aut
700	1	a Kamya, Moses R.4 aut
700	1	a Karema, Corine4 aut
700	1	a Kayentao, Kassoum4 aut
700	1	a Kiechel, Jean-Rene4 aut
700	1	a Kironde, Fred4 aut
700	1	a Kofoed, Poul-Erik4 aut
700	1	a Kremsner, Peter G.4 aut
700	1	a Krishna, Sanjeev4 aut
700	1	a Lameyre, Valerie4 aut
700	1	a Lell, Bertrand4 aut
700	1	a Lima, Angeles4 aut
700	1	a Makanga, Michael4 aut
700	1	a Malik, ElFatih M.4 aut
700	1	a Marsh, Kevin4 aut
700	1	a Mårtensson, Andreas4 aut
700	1	a Massougbodji, Achille4 aut
700	1	a Menan, Herve4 aut
700	1	a Menard, Didier4 aut
700	1	a Menendez, Clara4 aut
700	1	a Mens, Petra F.4 aut
700	1	a Meremikwu, Martin4 aut
700	1	a Moreira, Clarissa4 aut
700	1	a Nabasumba, Carolyn4 aut
700	1	a Nambozi, Michael4 aut
700	1	a Ndiaye, Jean-Louis4 aut
700	1	a Ngasala, Billy E.4 aut
700	1	a Nikiema, Frederic4 aut
700	1	a Nsanzabana, Christian4 aut
700	1	a Ntoumi, Francine4 aut
700	1	a Oguike, Mary4 aut
700	1	a Ogutu, Bernhards R.4 aut
700	1	a Olliaro, Piero4 aut
700	1	a Omar, Sabah A.4 aut
700	1	a Ouedraogo, Jean-Bosco4 aut
700	1	a Owusu-Agyei, Seth4 aut
700	1	a Penali, Louis K.4 aut
700	1	a Pene, Mbaye4 aut
700	1	a Peshu, Judy4 aut
700	1	a Piola, Patrice4 aut
700	1	a Plowe, Christopher V.4 aut
700	1	a Premji, Zul4 aut
700	1	a Price, Ric N.4 aut
700	1	a Randrianarivelojosia, Milijaona4 aut
700	1	a Rombo, Lars4 aut
700	1	a Roper, Cally4 aut
700	1	a Rosenthal, Philip J.4 aut
700	1	a Sagara, Issaka4 aut
700	1	a Same-Ekobo, Albert4 aut
700	1	a Sawa, Patrick4 aut
700	1	a Schallig, Henk D. F. H.4 aut
700	1	a Schramm, Birgit4 aut
700	1	a Seck, Amadou4 aut
700	1	a Shekalaghe, Seif A.4 aut
700	1	a Sibley, Carol H.4 aut
700	1	a Sinou, Vronique4 aut
700	1	a Sirima, Sodiomon B.4 aut
700	1	a Som, Fabrice A.4 aut
700	1	a Sow, Doudou4 aut
700	1	a Staedke, Sarah G.4 aut
700	1	a Stepniewska, Kasia4 aut
700	1	a Sutherland, Colin J.4 aut
700	1	a Swarthout, Todd D.4 aut
700	1	a Sylla, Khadime4 aut
700	1	a Talisuna, Ambrose O.4 aut
700	1	a Taylor, Walter R. J.4 aut
700	1	a Temu, Emmanuel A.4 aut
700	1	a Thwing, Julie I.4 aut
700	1	a Tine, Roger C. K.4 aut
700	1	a Tinto, Halidou4 aut
700	1	a Tommasini, Silva4 aut
700	1	a Toure, Offianan A.4 aut
700	1	a Ursing, Johan4 aut
700	1	a Vaillant, Michel T.4 aut
700	1	a Valentini, Giovanni4 aut0 98656
700	1	a Van den Broek, Ingrid4 aut
700	1	a Van Vugt, Michele4 aut
700	1	a Ward, Stephen A.4 aut
700	1	a Winstanley, Peter A.4 aut
700	1	a Yavo, William4 aut
700	1	a Yeka, Adoke4 aut
700	1	a Zolia, Yah M.4 aut
700	1	a Zongo, Issaka4 aut
710	1 2	a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl
772	1 8	i channel recordw 19753896
773	0 8	i Värdpublikationt BMC Medicineg 13x 1741-7015
856	4 0	u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-265956
856	4 0	u http://dx.doi.org/10.1186/s12916-015-0445-x
856	4 0	u http://uu.diva-portal.org/smash/get/diva2:867192/FULLTEXT01
900	1 s	6 700a Greenwood, B.u Greenwood, Brian
900	1 s	6 700a Valentini, Giovanni.t Sonat, blockflöjt (3), violin (2), viola (3),b.c.u Valentini, Giovanni
841		5 APISa x ab 170323\|\|0000\|\|\|\|\|001\|\|\|\|\|\|000000e 1
024	7	5 APISa urn:nbn:se:uu:diva-2659562 urn
852		5 APISb APIS
856	4 0	5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-265956

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Av författaren/redakt...: Abdulla, Salim; Adam, Ishag; Adjei, George O.; Adjuik, Martin A ...; Alemayehu, Berek ...; Allan, Richard; visa fler...; Arinaitwe, Emman ...; Ashley, Elizabet ...; Ba, Mamadou S.; Barennes, Hubert; Barnes, Karen I.; Bassat, Quique; Baudin, Elisabet ...; Berens-Riha, Nic ...; Bjoerkman, Ander ...; Bompart, Francoi ...; Bonnet, Maryline; Borrmann, Steffe ...; Bousema, Teun; Brasseur, Philip ...; Bukirwa, Hasifa; Checchi, Frances ...; Dahal, Prabin; D'Alessandro, Um ...; Desai, Meghna; Dicko, Alassane; Djimde, Abdoulay ...; Dorsey, Grant; Doumbo, Ogobara ...; Drakeley, Chris ...; Duparc, Stephan; Eshetu, Teferi; Espie, Emmanuell ...; Etard, Jean-Fran ...; Faiz, Abul M.; Falade, Catherin ...; Fanello, Caterin ...; Faucher, Jean-Fr ...; Faye, Babacar; Faye, Oumar; Filler, Scott; Flegg, Jennifer ...; Fofana, Bakary; Fogg, Carole; Gadalla, Nahla B ...; Gaye, Oumar; Genton, Blaise; Gething, Peter W ...; Gil, Jose P.; Gonzalez, Raquel; Grandesso, Franc ...; Greenhouse, Brya ...; Greenwood, Brian; Grivoyannis, Ana ...; Guerin, Philippe ...; Guthmann, Jean-P ...; Hamed, Kamal; Hamour, Sally; Hay, Simon I.; Hodel, Eva Maria; Humphreys, Georg ...; Hwang, Jimee; Ibrahim, Maman L ...; Jima, Daddi; Jones, Joel J.; Jullien, Vincent; Juma, Elizabeth; Kachur, Patrick ...; Kager, Piet A.; Kamugisha, Erasm ...; Kamya, Moses R.; Karema, Corine; Kayentao, Kassou ...; Kiechel, Jean-Re ...; Kironde, Fred; Kofoed, Poul-Eri ...; Kremsner, Peter ...; Krishna, Sanjeev; Lameyre, Valerie; Lell, Bertrand; Lima, Angeles; Makanga, Michael; Malik, ElFatih M ...; Marsh, Kevin; Mårtensson, Andr ...; Massougbodji, Ac ...; Menan, Herve; Menard, Didier; Menendez, Clara; Mens, Petra F.; Meremikwu, Marti ...; Moreira, Clariss ...; Nabasumba, Carol ...; Nambozi, Michael; Ndiaye, Jean-Lou ...; Ngasala, Billy E ...; Nikiema, Frederi ...; Nsanzabana, Chri ...; Ntoumi, Francine; Oguike, Mary; Ogutu, Bernhards ...; Olliaro, Piero; Omar, Sabah A.; Ouedraogo, Jean- ...; Owusu-Agyei, Set ...; Penali, Louis K.; Pene, Mbaye; Peshu, Judy; Piola, Patrice; Plowe, Christoph ...; Premji, Zul; Price, Ric N.; Randrianariveloj ...; Rombo, Lars; Roper, Cally; Rosenthal, Phili ...; Sagara, Issaka; Same-Ekobo, Albe ...; Sawa, Patrick; Schallig, Henk D ...; Schramm, Birgit; Seck, Amadou; Shekalaghe, Seif ...; Sibley, Carol H.; Sinou, Vronique; Sirima, Sodiomon ...; Som, Fabrice A.; Sow, Doudou; Staedke, Sarah G ...; Stepniewska, Kas ...; Sutherland, Coli ...; Swarthout, Todd ...; Sylla, Khadime; Talisuna, Ambros ...; Taylor, Walter R ...; Temu, Emmanuel A ...; Thwing, Julie I.; Tine, Roger C. K ...; Tinto, Halidou; Tommasini, Silva; Toure, Offianan ...; Ursing, Johan; Vaillant, Michel ...; Valentini, Giova ...; Van den Broek, I ...; Van Vugt, Michel ...; Ward, Stephen A.; Winstanley, Pete ...; Yavo, William; Yeka, Adoke; Zolia, Yah M.; Zongo, Issaka; visa färre...

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