onr:"21899093"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 10407naa a22027853a 4500 | |
| 001 | 21899093 | |
| 003 | SE-LIBR | |
| 005 | 20171109150024.0 | |
| 007 | cr|||||||||||| | |
| 008 | 171109s2017 sw |||| o |||| ||eng c | |
| 024 | 7 | a http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3328542 uri |
| 024 | 7 | a urn:nbn:se:uu:diva-3328542 urn |
| 024 | 7 | a 10.1038/s41467-017-00031-72 doi |
| 040 | a S | |
| 041 | 0 | a eng |
| 042 | 9 EPLK | |
| 100 | 1 | a Zillikens, M. Carola4 aut |
| 245 | 1 0 | a Large meta-analysis of genome-wide association studies identifies five loci for lean body massh [Elektronisk resurs] |
| 260 | b NATURE PUBLISHING GROUPc 2017 | |
| 500 | a Published | |
| 500 | a Vetenskapsrådet | |
| 500 | a Stiftelsen för strategisk forskning (SSF) | |
| 500 | a Torsten Söderbergs stiftelse | |
| 500 | a Ragnar Söderbergs stiftelse | |
| 506 | 0 | a gratis |
| 520 | a Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (p < 5 x 10(-8)) or suggestively genome wide (p < 2.3 x 10(-6)). Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lean body mass and in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean body mass was successful for five single-nucleotide polymorphisms in/ near HSD17B11, VCAN, ADAMTSL3, IRS1, and FTO for total lean body mass and for three single-nucleotide polymorphisms in/ near VCAN, ADAMTSL3, and IRS1 for appendicular lean body mass. Our findings provide new insight into the genetics of lean body mass. | |
| 650 | 7 | a Medical and Health Sciences2 hsv |
| 650 | 7 | a Medicin och hälsovetenskap2 hsv |
| 700 | 1 | a Demissie, Serkalem4 aut |
| 700 | 1 | a Hsu, Yi-Hsiang4 aut |
| 700 | 1 | a Yerges-Armstrong, Laura M.4 aut |
| 700 | 1 | a Chou, Wen-Chi4 aut |
| 700 | 1 | a Stolk, Lisette4 aut |
| 700 | 1 | a Livshits, Gregory4 aut |
| 700 | 1 | a Broer, Linda4 aut |
| 700 | 1 | a Johnson, Toby4 aut |
| 700 | 1 | a Koller, Daniel L.4 aut |
| 700 | 1 | a Kutalik, Zoltyn4 aut |
| 700 | 1 | a Luan, Jian'an4 aut |
| 700 | 1 | a Malkin, Ida4 aut |
| 700 | 1 | a Ried, Janina S.4 aut |
| 700 | 1 | a Smith, Albert V.4 aut |
| 700 | 1 | a Thorleifsson, Gudmar4 aut |
| 700 | 1 | a Vandenput, Liesbeth4 aut |
| 700 | 1 | a Zhao, Jing Hua4 aut |
| 700 | 1 | a Zhang, Weihua4 aut |
| 700 | 1 | a Aghdassi, Ali4 aut |
| 700 | 1 | a Akesson, Kristina4 aut |
| 700 | 1 | a Amin, Najaf4 aut |
| 700 | 1 | a Baier, Leslie J.4 aut |
| 700 | 1 | a Barroso, Ines4 aut |
| 700 | 1 | a Bennett, David A.4 aut |
| 700 | 1 | a Bertram, Lars4 aut |
| 700 | 1 | a Biffar, Rainer4 aut |
| 700 | 1 | a Bochud, Murielle4 aut |
| 700 | 1 | a Boehnke, Michael4 aut |
| 700 | 1 | a Borecki, Ingrid B.4 aut |
| 700 | 1 | a Buchman, Aron S.4 aut |
| 700 | 1 | a Byberg, Liisa4 aut |
| 700 | 1 | a Campbell, Harry4 aut |
| 700 | 1 | a Obanda, Natalia Campos4 aut |
| 700 | 1 | a Cauley, Jane A.4 aut |
| 700 | 1 | a Cawthon, Peggy M.4 aut |
| 700 | 1 | a Cederberg, Henna4 aut |
| 700 | 1 | a Chen, Zhao4 aut0 45721 |
| 700 | 1 | a Cho, Nam H.4 aut |
| 700 | 1 | a Choi, Hyung Jin4 aut |
| 700 | 1 | a Claussnitzer, Melina4 aut |
| 700 | 1 | a Collins, Francis4 aut |
| 700 | 1 | a Cummings, Steven R.4 aut |
| 700 | 1 | a De Jager, Philip L.4 aut |
| 700 | 1 | a Demuth, Ilja4 aut |
| 700 | 1 | a Dhonukshe-Rutten, Rosalie A. M.4 aut |
| 700 | 1 | a Diatchenko, Luda4 aut |
| 700 | 1 | a Eiriksdottir, Gudny4 aut |
| 700 | 1 | a Enneman, Anke W.4 aut |
| 700 | 1 | a Erdos, Mike4 aut |
| 700 | 1 | a Eriksson, Johan G.4 aut |
| 700 | 1 | a Eriksson, Joel4 aut |
| 700 | 1 | a Estrada, Karol4 aut |
| 700 | 1 | a Evans, Daniel S.4 aut |
| 700 | 1 | a Feitosa, Mary F.4 aut |
| 700 | 1 | a Fu, Mao4 aut |
| 700 | 1 | a Garcia, Melissa4 aut |
| 700 | 1 | a Gieger, Christian4 aut |
| 700 | 1 | a Girke, Thomas4 aut |
| 700 | 1 | a Glazer, Nicole L.4 aut |
| 700 | 1 | a Grallert, Harald4 aut |
| 700 | 1 | a Grewal, Jagvir4 aut |
| 700 | 1 | a Han, Bok-Ghee4 aut |
| 700 | 1 | a Hanson, Robert L.4 aut |
| 700 | 1 | a Hayward, Caroline4 aut |
| 700 | 1 | a Hofman, Albert4 aut |
| 700 | 1 | a Hoffman, Eric P.4 aut |
| 700 | 1 | a Homuth, Georg4 aut |
| 700 | 1 | a Hsueh, Wen-Chi4 aut |
| 700 | 1 | a Hubal, Monica J.4 aut |
| 700 | 1 | a Hubbard, Alan4 aut |
| 700 | 1 | a Huffman, Kim M.4 aut |
| 700 | 1 | a Husted, Lise B.4 aut |
| 700 | 1 | a Illig, Thomas4 aut |
| 700 | 1 | a Ingelsson, Erikd 1975-4 aut0 264196 |
| 700 | 1 | a Ittermann, Till4 aut |
| 700 | 1 | a Jansson, John-Olov4 aut |
| 700 | 1 | a Jordan, Joanne M.4 aut |
| 700 | 1 | a Jula, Antti4 aut |
| 700 | 1 | a Karlsson, Magnus4 aut |
| 700 | 1 | a Khaw, Kay-Tee4 aut |
| 700 | 1 | a Kilpainen, Tuomas O.4 aut |
| 700 | 1 | a Klopp, Norman4 aut |
| 700 | 1 | a Kloth, Jacqueline S. L.4 aut |
| 700 | 1 | a Koistinen, Heikki A.4 aut |
| 700 | 1 | a Kraus, William E.4 aut |
| 700 | 1 | a Kritchevsky, Stephen4 aut |
| 700 | 1 | a Kuulasmaa, Teemu4 aut |
| 700 | 1 | a Kuusisto, Johanna4 aut |
| 700 | 1 | a Laakso, Markku4 aut |
| 700 | 1 | a Lahti, Jari4 aut |
| 700 | 1 | a Lang, Thomas4 aut |
| 700 | 1 | a Langdahl, Bente L.4 aut |
| 700 | 1 | a Launer, Lenore J.4 aut |
| 700 | 1 | a Lee, Jong-Young4 aut |
| 700 | 1 | a Lerch, Markus M.4 aut |
| 700 | 1 | a Lewis, Joshua R.4 aut |
| 700 | 1 | a Lind, Lars4 aut |
| 700 | 1 | a Lindgren, Cecilia4 aut |
| 700 | 1 | a Liu, Yongmei4 aut |
| 700 | 1 | a Liu, Tian4 aut |
| 700 | 1 | a Liu, Youfang4 aut |
| 700 | 1 | a Ljunggren, Östen4 aut |
| 700 | 1 | a Lorentzon, Mattias4 aut |
| 700 | 1 | a Luben, Robert N.4 aut |
| 700 | 1 | a Maixner, William4 aut |
| 700 | 1 | a McGuigan, Fiona E.4 aut |
| 700 | 1 | a Medina-Gomez, Carolina4 aut |
| 700 | 1 | a Meitinger, Thomas4 aut |
| 700 | 1 | a Melhus, Håkan4 aut |
| 700 | 1 | a Mellstrom, Dan4 aut |
| 700 | 1 | a Melov, Simon4 aut |
| 700 | 1 | a Michaëlsson, Karld 1959-4 aut |
| 700 | 1 | a Mitchell, Braxton D.4 aut |
| 700 | 1 | a Morris, Andrew P.4 aut |
| 700 | 1 | a Mosekilde, Leif4 aut |
| 700 | 1 | a Newman, Anne4 aut |
| 700 | 1 | a Nielson, Carrie M.4 aut |
| 700 | 1 | a O'Connell, Jeffrey R.4 aut |
| 700 | 1 | a Oostra, Ben A.4 aut |
| 700 | 1 | a Orwoll, Eric S.4 aut |
| 700 | 1 | a Palotie, Aarno4 aut |
| 700 | 1 | a Parker, Stephan4 aut |
| 700 | 1 | a Peacock, Munro4 aut |
| 700 | 1 | a Perola, Markus4 aut |
| 700 | 1 | a Peters, Annette4 aut |
| 700 | 1 | a Polasek, Ozren4 aut |
| 700 | 1 | a Prince, Richard L.4 aut |
| 700 | 1 | a Raikkonen, Katri4 aut |
| 700 | 1 | a Ralston, Stuart H.4 aut |
| 700 | 1 | a Ripatti, Samuli4 aut |
| 700 | 1 | a Robbins, John A.4 aut |
| 700 | 1 | a Rotter, Jerome I.4 aut |
| 700 | 1 | a Rudan, Igor4 aut |
| 700 | 1 | a Salomaa, Veikko4 aut |
| 700 | 1 | a Satterfield, Suzanne4 aut |
| 700 | 1 | a Schadt, Eric E.4 aut |
| 700 | 1 | a Schipf, Sabine4 aut |
| 700 | 1 | a Scott, Laura4 aut |
| 700 | 1 | a Sehmi, Joban4 aut |
| 700 | 1 | a Shen, Jian4 aut |
| 700 | 1 | a Shin, Chan Soo4 aut |
| 700 | 1 | a Sigurdsson, Gunnar4 aut |
| 700 | 1 | a Smith, Shad4 aut |
| 700 | 1 | a Soranzo, Nicole4 aut |
| 700 | 1 | a Stancakova, Alena4 aut |
| 700 | 1 | a Steinhagen-Thiessen, Elisabeth4 aut |
| 700 | 1 | a Streeten, Elizabeth A.4 aut |
| 700 | 1 | a Styrkarsdottir, Unnur4 aut |
| 700 | 1 | a Swart, Karin M. A.4 aut |
| 700 | 1 | a Tan, Sian-Tsung4 aut |
| 700 | 1 | a Tarnopolsky, Mark A.4 aut |
| 700 | 1 | a Thompson, Patricia4 aut |
| 700 | 1 | a Thomson, Cynthia A.4 aut |
| 700 | 1 | a Thorsteinsdottir, Unnur4 aut |
| 700 | 1 | a Tikkanen, Emmi4 aut |
| 700 | 1 | a Tranah, Gregory J.4 aut |
| 700 | 1 | a Tuomilehto, Jaakko4 aut |
| 700 | 1 | a van Schoor, Natasja M.4 aut |
| 700 | 1 | a Verma, Arjun4 aut |
| 700 | 1 | a Vollenweider, Peter4 aut |
| 700 | 1 | a Voelzke, Henry4 aut |
| 700 | 1 | a Wactawski-Wende, Jean4 aut |
| 700 | 1 | a Walker, Mark4 aut |
| 700 | 1 | a Weedon, Michael N.4 aut |
| 700 | 1 | a Welch, Ryan4 aut |
| 700 | 1 | a Wichman, H. -Erich4 aut |
| 700 | 1 | a Widen, Elisabeth4 aut |
| 700 | 1 | a Williams, Frances M. K.4 aut |
| 700 | 1 | a Wilson, James F.4 aut |
| 700 | 1 | a Wright, Nicole C.4 aut |
| 700 | 1 | a Xie, Weijia4 aut |
| 700 | 1 | a Yu, Lei4 aut |
| 700 | 1 | a Zhou, Yanhua4 aut |
| 700 | 1 | a Chambers, John C.4 aut |
| 700 | 1 | a Doring, Angela4 aut |
| 700 | 1 | a van Duijn, Cornelia M.4 aut |
| 700 | 1 | a Econs, Michael J.4 aut |
| 700 | 1 | a Gudnason, Vilmundur4 aut |
| 700 | 1 | a Kooner, Jaspal S.4 aut |
| 700 | 1 | a Psaty, Bruce M.4 aut |
| 700 | 1 | a Spector, Timothy D.4 aut |
| 700 | 1 | a Stefansson, Kari4 aut |
| 700 | 1 | a Rivadeneira, Fernando4 aut |
| 700 | 1 | a Uitterlinden, Andre G.4 aut |
| 700 | 1 | a Wareham, Nicholas J.4 aut |
| 700 | 1 | a Ossowski, Vicky4 aut |
| 700 | 1 | a Waterworth, Dawn4 aut |
| 700 | 1 | a Loos, Ruth J. F.4 aut |
| 700 | 1 | a Karasik, David4 aut |
| 700 | 1 | a Harris, Tamara B.4 aut |
| 700 | 1 | a Ohlsson, Claes4 aut |
| 700 | 1 | a Kiel, Douglas P.4 aut |
| 710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
| 710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
| 710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
| 710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
| 710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
| 772 | 1 8 | i channel recordw 19753896 |
| 773 | 0 8 | i Värdpublikationt Nature Communicationsg 8x 2041-1723 |
| 856 | 4 0 | u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-332854 |
| 856 | 4 0 | u http://dx.doi.org/10.1038/s41467-017-00031-7 |
| 856 | 4 0 | u http://uu.diva-portal.org/smash/get/diva2:1155572/FULLTEXT01 |
| 900 | 1 s | 6 700a Chen, Chaou Chen, Zhao |
| 841 | 5 APISa x ab 171109||0000|||||001||||||000000e 1 | |
| 024 | 7 | 5 APISa urn:nbn:se:uu:diva-3328542 urn |
| 852 | 5 APISb APIS | |
| 856 | 4 0 | 5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-332854 |
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