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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004141naa a22006133a 4500
00122067877
003SE-LIBR
00520171206153021.0
007cr||||||||||||
008171206s2014 sw |||| o |||| ||eng c
0247 a http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2379152 uri
0247 a urn:nbn:se:uu:diva-2379152 urn
0247 a 10.1371/journal.pone.01108272 doi
040 a S
0410 a eng
042 9 EPLK
1001 a Magnusdottir, Ola Kally4 aut
2451 0a Whole Grain Rye Intake, Reflected by a Biomarker, Is Associated with Favorable Blood Lipid Outcomes in Subjects with the Metabolic Syndromeh [Elektronisk resurs]b A Randomized Study
260 c 2014
500 a Published
5060 a gratis
520 a Background and Aim: Few studies have explored the possible plasma cholesterol lowering effects of rye consumption. The aim of this secondary analysis in the SYSDIET study was to investigate the association between plasma alkylresorcinols (AR), a biomarker for whole grain wheat and rye intake, and blood lipid concentrations in a population with metabolic syndrome. Furthermore, we analyzed the associations between the AR C17:0/C21:0 ratio, a suggested marker of the relative intake of whole grain/bran rye, and blood lipid concentrations. Methods: Participants were 30-65 years of age, with body mass index (BMI) 27-40 kg/m(2) and had metabolic syndrome. Individuals were recruited through six centers in the Nordic countries and randomized either to a healthy Nordic diet (ND, n = 93), rich in whole grain rye and wheat, as well as berries, fruits and vegetables, rapeseed oil, three fish meals per week and low-fat dairy products, or a control diet (n = 65) for 18/24 weeks. Associations between total plasma AR concentration and C17:0/C21:0 homologue ratio and blood lipids were investigated in pooled (ND + control group) regression analyses at 18/24 weeks adjusted for baseline value for the dependent variable, age, BMI and statin use. Results: When adjusted for confounders, total plasma AR at 18/24 weeks was not significantly associated with blood lipids but the AR ratio C17:0/C21:0 was inversely associated with LDL cholesterol concentrations (B (95% Cl): -0.41 (-0.80 to -0.02)), log LDL/HDL cholesterol ratio (-0.20 (-0.37 to -0.03)), log non-HDL cholesterol (-0.20 (-0.37 to -0.03)), log apolipoprotein B (-0.12 (-0.24 to 0.00)) and log triglyceride concentrations (-0.35 (-0.59 to -0.12)). Discussion: Increased proportion of whole grain rye, reflected by a biomarker, in the diet is associated with favorable blood lipid outcomes, a relationship that should be further investigated.
650 7a Medical and Health Sciences2 hsv
650 7a Health Sciences2 hsv
650 7a Nutrition and Dietetics2 hsv
650 7a Medicin och hälsovetenskap2 hsv
650 7a Hälsovetenskaper2 hsv
650 7a Näringslära2 hsv
7001 a Landberg, Rikard4 aut
7001 a Gunnarsdottir, Ingibjorg4 aut
7001 a Cloetens, Lieselotte4 aut
7001 a Akesson, Bjorn4 aut
7001 a Rosqvist, Fredrik4 aut
7001 a Schwab, Ursula4 aut
7001 a Herzig, Karl-Heinz4 aut
7001 a Hukkanen, Janne4 aut
7001 a Savolainen, Markku J.4 aut
7001 a Brader, Lea4 aut
7001 a Hermansen, Kjeld4 aut
7001 a Kolehmainen, Marjukka4 aut
7001 a Poutanen, Kaisa4 aut
7001 a Uusitupa, Matti4 aut
7001 a Riserus, Ulf4 aut
7001 a Thorsdottir, Inga4 aut
7101 2a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl
7721 8i channel recordw 19753896
7730 8i Värdpublikationt PLoS ONEg 9:10, e110827x 1932-6203
8564 0u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-237915
8564 0u http://dx.doi.org/10.1371/journal.pone.0110827
8564 0u http://uu.diva-portal.org/smash/get/diva2:770601/FULLTEXT01
841 5 APISa x ab 171206||0000|||||001||||||000000e 1
0247 5 APISa urn:nbn:se:uu:diva-2379152 urn
852 5 APISb APIS
8564 05 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-237915

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