Sökning: onr:"22069227" > Gene-Wide Analysis ...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 10080caa a22026893a 4500 | |
001 | 22069227 | |
003 | SE-LIBR | |
005 | 20200525083134.0 | |
007 | cr ||| ||||| | |
008 | 171206s2014 sw |||||o|||||000 ||eng|c | |
024 | 7 | a http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2299592 uri |
024 | 7 | a urn:nbn:se:uu:diva-2299592 urn |
024 | 7 | a 10.1371/journal.pone.00946612 doi |
040 | a Se a | |
041 | 0 | a eng |
042 | 9 EPLK | |
100 | 1 | a Escott-Price, Valentina4 aut |
245 | 1 0 | a Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Diseaseh [Elektronisk resurs] |
264 | 1 | c 2014 |
500 | a Published | |
506 | 0 | a gratis |
520 | a Background: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer's Project Consortium, comprising over 7 m genotypes from 25,580 Alzheimer's cases and 48,466 controls. Principal Findings: In addition to earlier reported genes, we detected genome-wide significant loci on chromosomes 8 (TP53INP1, p = 1.4x10(-6)) and 14 (IGHV1-67 p = 7.9x10(-8)) which indexed novel susceptibility loci. Significance: The additional genes identified in this study, have an array of functions previously implicated in Alzheimer's disease, including aspects of energy metabolism, protein degradation and the immune system and add further weight to these pathways as potential therapeutic targets in Alzheimer's disease. | |
650 | 7 | a Medical and Health Sciences2 hsv |
650 | 7 | a Clinical Medicine2 hsv |
650 | 7 | a Geriatrics2 hsv |
650 | 7 | a Medicin och hälsovetenskap2 hsv |
650 | 7 | a Klinisk medicin2 hsv |
650 | 7 | a Geriatrik2 hsv |
700 | 1 | a Bellenguez, Celine4 aut |
700 | 1 | a Wang, Li-San4 aut |
700 | 1 | a Choi, Seung-Hoan4 aut |
700 | 1 | a Harold, Denise4 aut |
700 | 1 | a Jones, Lesley4 aut |
700 | 1 | a Holmans, Peter4 aut |
700 | 1 | a Gerrish, Amy4 aut |
700 | 1 | a Vedernikov, Alexey4 aut |
700 | 1 | a Richards, Alexander4 aut |
700 | 1 | a DeStefano, Anita L.4 aut |
700 | 1 | a Lambert, Jean-Charles4 aut |
700 | 1 | a Ibrahim-Verbaas, Carla A.4 aut |
700 | 1 | a Naj, Adam C.4 aut |
700 | 1 | a Sims, Rebecca4 aut |
700 | 1 | a Jun, Gyungah4 aut |
700 | 1 | a Bis, Joshua C.4 aut |
700 | 1 | a Beecham, Gary W.4 aut |
700 | 1 | a Grenier-Boley, Benjamin4 aut |
700 | 1 | a Russo, Giancarlo4 aut |
700 | 1 | a Thornton-Wells, Tricia A.4 aut |
700 | 1 | a Denning, Nicola4 aut |
700 | 1 | a Smith, Albert V.4 aut |
700 | 1 | a Chouraki, Vincent4 aut |
700 | 1 | a Thomas, Charlene4 aut |
700 | 1 | a Ikram, M. Arfan4 aut |
700 | 1 | a Zelenika, Diana4 aut |
700 | 1 | a Vardarajan, Badri N.4 aut |
700 | 1 | a Kamatani, Yoichiro4 aut |
700 | 1 | a Lin, Chiao-Feng4 aut |
700 | 1 | a Schmidt, Helena4 aut |
700 | 1 | a Kunkle, Brian4 aut |
700 | 1 | a Dunstan, Melanie L.4 aut |
700 | 1 | a Vronskaya, Maria4 aut |
700 | 1 | a Johnson, Andrew D.4 aut |
700 | 1 | a Ruiz, Agustin4 aut |
700 | 1 | a Bihoreau, Marie-Therese4 aut |
700 | 1 | a Reitz, Christiane4 aut |
700 | 1 | a Pasquier, Florence4 aut |
700 | 1 | a Hollingworth, Paul4 aut |
700 | 1 | a Hanon, Olivier4 aut |
700 | 1 | a Fitzpatrick, Annette L.4 aut |
700 | 1 | a Buxbaum, Joseph D.4 aut |
700 | 1 | a Campion, Dominique4 aut |
700 | 1 | a Crane, Paul K.4 aut |
700 | 1 | a Baldwin, Clinton4 aut |
700 | 1 | a Becker, Tim4 aut |
700 | 1 | a Gudnason, Vilmundur4 aut |
700 | 1 | a Cruchaga, Carlos4 aut |
700 | 1 | a Craig, David4 aut |
700 | 1 | a Amin, Najaf4 aut |
700 | 1 | a Berr, Claudine4 aut |
700 | 1 | a Lopez, Oscar L.4 aut |
700 | 1 | a De Jager, Philip L.4 aut |
700 | 1 | a Deramecourt, Vincent4 aut |
700 | 1 | a Johnston, Janet A.4 aut |
700 | 1 | a Evans, Denis4 aut |
700 | 1 | a Lovestone, Simon4 aut |
700 | 1 | a Letenneur, Luc4 aut |
700 | 1 | a Hernandez, Isabel4 aut |
700 | 1 | a Rubinsztein, David C.4 aut |
700 | 1 | a Eiriksdottir, Gudny4 aut |
700 | 1 | a Sleegers, Kristel4 aut |
700 | 1 | a Goate, Alison M.4 aut |
700 | 1 | a Fievet, Nathalie4 aut |
700 | 1 | a Huentelman, Matthew J.4 aut |
700 | 1 | a Gill, Michael4 aut |
700 | 1 | a Brown, Kristelle4 aut |
700 | 1 | a Kamboh, M. Ilyas4 aut |
700 | 1 | a Keller, Lina4 aut |
700 | 1 | a Barberger-Gateau, Pascale4 aut |
700 | 1 | a McGuinness, Bernadette4 aut |
700 | 1 | a Larson, Eric B.4 aut |
700 | 1 | a Myers, Amanda J.4 aut |
700 | 1 | a Dufouil, Carole4 aut |
700 | 1 | a Todd, Stephen4 aut |
700 | 1 | a Wallon, David4 aut |
700 | 1 | a Love, Seth4 aut |
700 | 1 | a Rogaeva, Ekaterina4 aut |
700 | 1 | a Gallacher, John4 aut |
700 | 1 | a St George-Hyslop, Peter4 aut |
700 | 1 | a Clarimon, Jordi4 aut |
700 | 1 | a Lleo, Alberto4 aut |
700 | 1 | a Bayer, Anthony4 aut |
700 | 1 | a Tsuang, Debby W.4 aut |
700 | 1 | a Yu, Lei4 aut |
700 | 1 | a Tsolaki, Magda4 aut |
700 | 1 | a Bossu, Paola4 aut |
700 | 1 | a Spalletta, Gianfranco4 aut |
700 | 1 | a Proitsi, Petra4 aut |
700 | 1 | a Collinge, John4 aut |
700 | 1 | a Sorbi, Sandro4 aut |
700 | 1 | a Garcia, Florentino Sanchez4 aut |
700 | 1 | a Fox, Nick C.4 aut |
700 | 1 | a Hardy, John4 aut |
700 | 1 | a Deniz Naranjo, Maria Candida4 aut |
700 | 1 | a Bosco, Paolo4 aut |
700 | 1 | a Clarke, Robert4 aut |
700 | 1 | a Brayne, Carol4 aut |
700 | 1 | a Galimberti, Daniela4 aut |
700 | 1 | a Scarpini, Elio4 aut |
700 | 1 | a Bonuccelli, Ubaldo4 aut |
700 | 1 | a Mancuso, Michelangelo4 aut |
700 | 1 | a Siciliano, Gabriele4 aut |
700 | 1 | a Moebus, Susanne4 aut |
700 | 1 | a Mecocci, Patrizia4 aut |
700 | 1 | a Del Zompo, Maria4 aut |
700 | 1 | a Maier, Wolfgang4 aut |
700 | 1 | a Hampel, Harald4 aut |
700 | 1 | a Pilotto, Alberto4 aut |
700 | 1 | a Frank-Garcia, Ana4 aut |
700 | 1 | a Panza, Francesco4 aut |
700 | 1 | a Solfrizzi, Vincenzo4 aut |
700 | 1 | a Caffarra, Paolo4 aut |
700 | 1 | a Nacmias, Benedetta4 aut |
700 | 1 | a Perry, William4 aut |
700 | 1 | a Mayhaus, Manuel4 aut |
700 | 1 | a Lannfelt, Lars4 aut |
700 | 1 | a Hakonarson, Hakon4 aut |
700 | 1 | a Pichler, Sabrina4 aut |
700 | 1 | a Carrasquillo, Minerva M.4 aut |
700 | 1 | a Ingelsson, Martin,d 1965-4 aut0 https://libris.kb.se/3fq1pgh11l494wzc#it |
700 | 1 | a Beekly, Duane4 aut |
700 | 1 | a Alvarez, Victoria4 aut |
700 | 1 | a Zou, Fanggeng4 aut |
700 | 1 | a Valladares, Otto4 aut |
700 | 1 | a Younkin, Steven G.4 aut |
700 | 1 | a Coto, Eliecer4 aut |
700 | 1 | a Hamilton-Nelson, Kara L.4 aut |
700 | 1 | a Gu, Wei4 aut |
700 | 1 | a Razquin, Cristina4 aut |
700 | 1 | a Pastor, Pau4 aut |
700 | 1 | a Mateo, Ignacio4 aut |
700 | 1 | a Owen, Michael J.4 aut |
700 | 1 | a Faber, Kelley M.4 aut |
700 | 1 | a Jonsson, Palmi V.4 aut |
700 | 1 | a Combarros, Onofre4 aut |
700 | 1 | a O'Donovan, Michael C.4 aut |
700 | 1 | a Cantwell, Laura B.4 aut |
700 | 1 | a Soininen, Hilkka4 aut |
700 | 1 | a Blacker, Deborah4 aut |
700 | 1 | a Mead, Simon4 aut |
700 | 1 | a Mosley, Thomas H.4 aut |
700 | 1 | a Bennett, David A.4 aut |
700 | 1 | a Harris, Tamara B.4 aut |
700 | 1 | a Fratiglioni, Laura4 aut |
700 | 1 | a Holmes, Clive4 aut |
700 | 1 | a de Bruijn, Renee F. A. G.4 aut |
700 | 1 | a Passmore, Peter4 aut |
700 | 1 | a Montine, Thomas J.4 aut |
700 | 1 | a Bettens, Karolien4 aut |
700 | 1 | a Rotter, Jerome I.4 aut |
700 | 1 | a Brice, Alexis4 aut |
700 | 1 | a Morgan, Kevin4 aut |
700 | 1 | a Foroud, Tatiana M.4 aut |
700 | 1 | a Kukull, Walter A.4 aut |
700 | 1 | a Hannequin, Didier4 aut |
700 | 1 | a Powell, John F.4 aut |
700 | 1 | a Nalls, Michael A.4 aut |
700 | 1 | a Ritchie, Karen4 aut |
700 | 1 | a Lunetta, Kathryn L.4 aut |
700 | 1 | a Kauwe, John S. K.4 aut |
700 | 1 | a Boerwinkle, Eric4 aut |
700 | 1 | a Riemenschneider, Matthias4 aut |
700 | 1 | a Boada, Merce4 aut |
700 | 1 | a Hiltunen, Mikko4 aut |
700 | 1 | a Martin, Eden R.4 aut |
700 | 1 | a Schmidt, Reinhold4 aut |
700 | 1 | a Rujescu, Dan4 aut |
700 | 1 | a Dartigues, Jean-Francois4 aut |
700 | 1 | a Mayeux, Richard4 aut |
700 | 1 | a Tzourio, Christophe4 aut |
700 | 1 | a Hofman, Albert4 aut |
700 | 1 | a Noethen, Markus M.4 aut |
700 | 1 | a Graff, Caroline4 aut |
700 | 1 | a Psaty, Bruce M.4 aut |
700 | 1 | a Haines, Jonathan L.4 aut |
700 | 1 | a Lathrop, Mark4 aut |
700 | 1 | a Pericak-Vance, Margaret A.4 aut |
700 | 1 | a Launer, Lenore J.4 aut |
700 | 1 | a Van Broeckhoven, Christine4 aut |
700 | 1 | a Farrer, Lindsay A.4 aut |
700 | 1 | a van Duijn, Cornelia M.4 aut |
700 | 1 | a Ramirez, Alfredo4 aut |
700 | 1 | a Seshadri, Sudha4 aut |
700 | 1 | a Schellenberg, Gerard D.4 aut |
700 | 1 | a Amouyel, Philippe4 aut |
700 | 1 | a Williams, Julie4 aut |
710 | 1 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
772 | 0 0 | i channel recordw 19753896 |
773 | 0 0 | t PLoS ONEg 9:6, e94661x 1932-6203 |
856 | 4 0 | u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-229959 |
856 | 4 0 | u http://dx.doi.org/10.1371/journal.pone.0094661 |
856 | 4 0 | u http://uu.diva-portal.org/smash/get/diva2:738609/FULLTEXT01 |
887 | a {"@id":"k3wbs87w4svxs7v","modified":"2020-05-25T08:31:34.652+02:00","checksum":"60826714824"}2 librisxl | |
841 | 5 APISa x ab 171206||0000|||||001||||||000000e u | |
024 | 7 | 5 APISa urn:nbn:se:uu:diva-2299592 urn |
852 | 5 APISb APIS | |
856 | 4 0 | 5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-229959 |
887 | 5 APISa {"@id":"ns1dlrnt1r8wlbq","modified":"2017-12-06T16:21:50+01:00","checksum":"130269063906"}2 librisxl |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy