onr:"22083902"
Sökning: onr:"22083902" > C-reactive protein,...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04269naa a22005653a 4500 | |
| 001 | 22083902 | |
| 003 | SE-LIBR | |
| 005 | 20171207165538.0 | |
| 007 | cr|||||||||||| | |
| 008 | 171207s2013 sw |||| o |||| ||eng c | |
| 024 | 7 | a http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-961522 uri |
| 024 | 7 | a urn:nbn:se:liu:diva-961522 urn |
| 024 | 7 | a 10.3109/08916934.2013.7649922 doi |
| 040 | a S | |
| 041 | 0 | a eng |
| 042 | 9 EPLK | |
| 100 | 1 | a Sjöwall, Christoffer4 aut |
| 245 | 1 0 | a C-reactive protein, immunoglobulin G and complement co-localize in renal immune deposits of proliferative lupus nephritish [Elektronisk resurs] |
| 260 | b Informa Healthcarec 2013 | |
| 500 | a Published | |
| 506 | 0 | a gratis |
| 520 | a The pattern recognition molecules C-reactive protein (CRP) and C1q are of big interest in relation to the pathogenesis of systemic lupus erythematosus (SLE). Circulating autoantibodies against CRP and C1q are frequently found in SLE patients with active disease, particularly in lupus nephritis (LN), and rising levels reportedly relate to disease activity and outcome. If CRP-, or dsDNA- and/or C1q-containing immune complexes (ICs) are pathogenic in LN, glomerular IgG-deposits would be expected to co-localize with these antigens. In search for proof of this concept, renal biospsies from patients with active LN ( n =5) were examined with high-resolution immunogold electron microscopy. Renal biopsies from patients with Henoch-Schönlein purpura, pauci-immune nephritis and renal cancer served as controls. IgG antibodies against CRP, C1q and nucleosomes were analyzed in pre–post flare sera. We could demonstrate that CRP, C1q, C3c and dsDNA were co-localized with IgG in electron dense deposits in the glomerular basement membrane/subendothelial space in all of the 5 LN patients. Deposits of IgG, CRP, complement and dsDNA were 10-fold higher in LN compared to controls. All SLE patients had circulating anti-nucleosome antibodies; 4/5 had serum antibodies against CRP, dsDNA, and C1q at biopsy/flare. Despite a limited number of cases, the results support the notion of a pathogenic role not only for anti-dsDNA antibodies, but also for anti-CRP and anti-C1q in LN. The glomerular ICs may have been generated by deposition of circulating ICs or by in situ IC formation. | |
| 650 | 7 | a Medical and Health Sciences2 hsv |
| 650 | 7 | a Medicin och hälsovetenskap2 hsv |
| 650 | 7 | a MEDICINE2 svep |
| 650 | 7 | a MEDICIN2 svep |
| 653 | 0 | a C-reactive protein; C1q; autoantibody; immune complex; lupus nephritis; systemic lupus erythematosus; immunogold electron microscopy |
| 700 | 1 | a Olin, Anders I.4 aut |
| 700 | 1 | a Skogh, Thomas4 aut |
| 700 | 1 | a Wetterö, Jonas4 aut |
| 700 | 1 | a Mörgelin, Matthias4 aut |
| 700 | 1 | a Nived, Ola4 aut |
| 700 | 1 | a Sturfelt, Gunnar4 aut |
| 700 | 1 | a Bengtsson, Anders A.4 aut |
| 710 | 1 2 | a Linköpings universitetb Institutionen för klinisk och experimentell medicin4 pbl0 347333 |
| 710 | 1 2 | a Linköpings universitetb Hälsouniversitetet4 pbl |
| 710 | 1 2 | a Östergötlands Läns Landstingb Hjärt- och Medicincentrum4 pbl |
| 710 | 1 2 | a Linköpings universitetb Institutionen för klinisk och experimentell medicin4 pbl0 347333 |
| 772 | 1 8 | i channel recordw 18478042 |
| 773 | 0 8 | i Värdpublikationt Autoimmunityg 46:3, 205-214x 0891-6934 |
| 856 | 4 0 | u http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-96152 |
| 856 | 4 0 | u http://dx.doi.org/10.3109/08916934.2013.764992 |
| 856 | 4 0 | u http://liu.diva-portal.org/smash/get/diva2:640718/FULLTEXT01 |
| 910 | 2 s | 6 710,710a IKEu Linköpings universitet.b Institutionen för klinisk och experimentell medicin |
| 910 | 2 s | 6 710,710a Linköping University.b Department of Clinical and Experimental Medicineu Linköpings universitet.b Institutionen för klinisk och experimentell medicin |
| 910 | 2 s | 6 710,710a Linköping University.b Faculty of Health Sciences.b Department of Clinical and Experimental Medicineu Linköpings universitet.b Institutionen för klinisk och experimentell medicin |
| 841 | 5 APISa x ab 171210||0000|||||001||||||000000e 1 | |
| 024 | 7 | 5 APISa urn:nbn:se:liu:diva-961522 urn |
| 852 | 5 APISb APIS | |
| 856 | 4 0 | 5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-96152 |
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