Sökning: WFRF:(Kooperberg C.) > Systematic Evaluati...
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000 | 08749naa a22020293a 4500 | |
001 | 20214750 | |
003 | SE-LIBR | |
005 | 20170330151409.0 | |
007 | cr|||||||||||| | |
008 | 170330s2017 sw |||| o |||| ||eng c | |
024 | 7 | a http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3189612 uri |
024 | 7 | a urn:nbn:se:uu:diva-3189612 urn |
024 | 7 | a 10.1016/j.jacc.2016.11.0562 doi |
040 | a S | |
041 | 0 | a eng |
042 | 9 EPLK | |
100 | 1 | a Webb, Thomas R.4 aut |
245 | 1 0 | a Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Diseaseh [Elektronisk resurs] |
260 | c 2017 | |
500 | a Published | |
506 | 0 | a gratis |
520 | a BACKGROUND Genome-wide association studies have so far identified 56 loci associated with risk of coronary artery disease (CAD). Many CAD loci show pleiotropy; that is, they are also associated with other diseases or traits. OBJECTIVES This study sought to systematically test if genetic variants identified for non-CAD diseases/traits also associate with CAD and to undertake a comprehensive analysis of the extent of pleiotropy of all CAD loci. METHODS In discovery analyses involving 42,335 CAD cases and 78,240 control subjects we tested the association of 29,383 common (minor allele frequency >5%) single nucleotide polymorphisms available on the exome array, which included a substantial proportion of known or suspected single nucleotide polymorphisms associated with common diseases or traits as of 2011. Suggestive association signals were replicated in an additional 30,533 cases and 42,530 control subjects. To evaluate pleiotropy, we tested CAD loci for association with cardiovascular risk factors (lipid traits, blood pressure phenotypes, body mass index, diabetes, and smoking behavior), as well as with other diseases/traits through interrogation of currently available genome-wide association study catalogs. RESULTS We identified 6 new loci associated with CAD at genome-wide significance: on 2q37 (KCNJ13-GIGYF2), 6p21 (C2), 11p15 (MRVI1-CTR9), 12q13 (LRP1), 12q24 (SCARB1), and 16q13 (CETP). Risk allele frequencies ranged from 0.15 to 0.86, and odds ratio per copy of the risk allele ranged from 1.04 to 1.09. Of 62 new and known CAD loci, 24 (38.7%) showed statistical association with a traditional cardiovascular risk factor, with some showing multiple associations, and 29 (47%) showed associations at p < 1 x 10(-4) with a range of other diseases/traits. CONCLUSIONS We identified 6 loci associated with CAD at genome-wide significance. Several CAD loci show substantial pleiotropy, which may help us understand the mechanisms by which these loci affect CAD risk. | |
650 | 7 | a Medical and Health Sciences2 hsv |
650 | 7 | a Medicin och hälsovetenskap2 hsv |
653 | 0 | a cholesteryl ester transfer protein |
653 | 0 | a expression quantitative trait loci |
653 | 0 | a genetics |
653 | 0 | a genome-wide association |
653 | 0 | a single nucleotide polymorphism |
700 | 1 | a Erdmann, Jeanette4 aut |
700 | 1 | a Stirrups, Kathleen E.4 aut |
700 | 1 | a Stitziel, Nathan O.4 aut |
700 | 1 | a Masca, Nicholas G. D.4 aut |
700 | 1 | a Jansen, Henning4 aut |
700 | 1 | a Kanoni, Stavroula4 aut |
700 | 1 | a Nelson, Christopher P.4 aut |
700 | 1 | a Ferrario, Paola G.4 aut |
700 | 1 | a Koenig, Inke R.4 aut |
700 | 1 | a Eicher, John D.4 aut |
700 | 1 | a Johnson, Andrew D.4 aut |
700 | 1 | a Hamby, Stephen E.4 aut |
700 | 1 | a Betsholtz, Christer4 aut |
700 | 1 | a Ruusalepp, Arno4 aut |
700 | 1 | a Franzen, Oscar4 aut |
700 | 1 | a Schadt, Eric E.4 aut |
700 | 1 | a Bjoerkegren, Johan L. M.4 aut |
700 | 1 | a Weeke, Peter E.4 aut |
700 | 1 | a Auer, Paul L.4 aut |
700 | 1 | a Schick, Ursula M.4 aut |
700 | 1 | a Lu, Yingchang4 aut |
700 | 1 | a Zhang, He4 aut |
700 | 1 | a Dube, Marie-Pierre4 aut |
700 | 1 | a Goel, Anuj4 aut |
700 | 1 | a Farrall, Martin4 aut |
700 | 1 | a Peloso, Gina M.4 aut |
700 | 1 | a Won, Hong-Hee4 aut |
700 | 1 | a Do, Ron4 aut |
700 | 1 | a van Iperen, Erik4 aut |
700 | 1 | a Kruppa, Jochen4 aut |
700 | 1 | a Mahajan, Anubha4 aut |
700 | 1 | a Scott, Robert A.4 aut |
700 | 1 | a Willenborg, Christina4 aut |
700 | 1 | a Braund, Peter S.4 aut |
700 | 1 | a van Capelleveen, Julian C.4 aut |
700 | 1 | a Doney, Alex S. F.4 aut |
700 | 1 | a Donnelly, Louise A.4 aut |
700 | 1 | a Asselta, Rosanna4 aut |
700 | 1 | a Merlini, Pier A.4 aut |
700 | 1 | a Duga, Stefano4 aut |
700 | 1 | a Marziliano, Nicola4 aut |
700 | 1 | a Denny, Josh C.4 aut |
700 | 1 | a Shaffer, Christian4 aut |
700 | 1 | a El-Mokhtari, Nour Eddine4 aut |
700 | 1 | a Franke, Andre4 aut |
700 | 1 | a Heilmann, Stefanie4 aut |
700 | 1 | a Hengstenberg, Christian4 aut |
700 | 1 | a Hoffmann, Per4 aut |
700 | 1 | a Holmen, Oddgeir L.4 aut |
700 | 1 | a Hveem, Kristian4 aut |
700 | 1 | a Jansson, Jan-Hakan4 aut |
700 | 1 | a Joeckel, Karl-Heinz4 aut |
700 | 1 | a Kessler, Thorsten4 aut |
700 | 1 | a Kriebel, Jennifer4 aut |
700 | 1 | a Laugwitz, Karl L.4 aut |
700 | 1 | a Marouli, Eirini4 aut |
700 | 1 | a Martinelli, Nicola4 aut |
700 | 1 | a McCarthy, Mark I.4 aut |
700 | 1 | a Van Zuydam, Natalie R.4 aut |
700 | 1 | a Meisinger, Christa4 aut |
700 | 1 | a Esko, Tonu4 aut |
700 | 1 | a Mihailov, Evelin4 aut |
700 | 1 | a Escher, Stefan A.4 aut |
700 | 1 | a Alver, Maris4 aut |
700 | 1 | a Moebus, Susanne4 aut |
700 | 1 | a Morris, Andrew D.4 aut |
700 | 1 | a Virtamo, Jarma4 aut |
700 | 1 | a Nikpay, Majid4 aut |
700 | 1 | a Olivieri, Oliviero4 aut |
700 | 1 | a Provost, Sylvie4 aut |
700 | 1 | a AlQarawi, Alaa4 aut |
700 | 1 | a Robertson, Neil R.4 aut |
700 | 1 | a Akinsansya, Karen O.4 aut |
700 | 1 | a Reilly, Dermot F.4 aut |
700 | 1 | a Vogt, Thomas F.4 aut |
700 | 1 | a Yin, Wu4 aut |
700 | 1 | a Asselbergs, Folkert W.4 aut |
700 | 1 | a Kooperberg, Charles4 aut |
700 | 1 | a Jackson, Rebecca D.4 aut |
700 | 1 | a Stahl, Eli4 aut |
700 | 1 | a Mueller-Nurasyid, Martina4 aut |
700 | 1 | a Strauch, Konstantin4 aut |
700 | 1 | a Varga, Tibor V.4 aut |
700 | 1 | a Waldenberger, Melanie4 aut |
700 | 1 | a Zeng, Lingyao4 aut |
700 | 1 | a Chowdhury, Rajiv4 aut |
700 | 1 | a Salomaa, Veikko4 aut |
700 | 1 | a Ford, Ian4 aut |
700 | 1 | a Jukema, J. Wouter4 aut |
700 | 1 | a Amouyel, Philippe4 aut |
700 | 1 | a Kontto, Jukka4 aut |
700 | 1 | a Nordestgaard, Borge G.4 aut |
700 | 1 | a Ferrieres, Jean4 aut |
700 | 1 | a Saleheen, Danish4 aut |
700 | 1 | a Sattar, Naveed4 aut |
700 | 1 | a Surendran, Praveen4 aut |
700 | 1 | a Wagner, Aline4 aut |
700 | 1 | a Young, Robin4 aut |
700 | 1 | a Howson, Joanna M. M.4 aut |
700 | 1 | a Butterworth, Adam S.4 aut |
700 | 1 | a Danesh, John4 aut |
700 | 1 | a Ardissino, Diego4 aut |
700 | 1 | a Bottinger, Erwin P.4 aut |
700 | 1 | a Erbel, Raimund4 aut |
700 | 1 | a Franks, Paul W.4 aut |
700 | 1 | a Girelli, Domenico4 aut |
700 | 1 | a Hall, Alistair S.4 aut |
700 | 1 | a Hovingh, G. Kees4 aut |
700 | 1 | a Kastrati, Adnan4 aut |
700 | 1 | a Lieb, Wolfgang4 aut |
700 | 1 | a Meitinger, Thomas4 aut |
700 | 1 | a Kraus, William E.4 aut |
700 | 1 | a Shah, Svati H.4 aut |
700 | 1 | a McPherson, Ruth4 aut |
700 | 1 | a Orho-Melander, Marju4 aut |
700 | 1 | a Melander, Olle4 aut |
700 | 1 | a Metspalu, Andres4 aut |
700 | 1 | a Palmer, Colin N. A.4 aut |
700 | 1 | a Peters, Annette4 aut |
700 | 1 | a Rader, Daniel J.4 aut |
700 | 1 | a Reilly, Muredach P.4 aut |
700 | 1 | a Loos, Ruth J. F.4 aut |
700 | 1 | a Reiner, Alex P.4 aut |
700 | 1 | a Roden, Dan M.4 aut |
700 | 1 | a Tardif, Jean-Claude4 aut |
700 | 1 | a Thompson, John R.4 aut |
700 | 1 | a Wareham, Nicholas J.4 aut |
700 | 1 | a Watkins, Hugh4 aut |
700 | 1 | a Willer, Cristen J.4 aut |
700 | 1 | a Samani, Nilesh J.4 aut |
700 | 1 | a Schunkert, Heribert4 aut |
700 | 1 | a Deloukas, Panos4 aut |
700 | 1 | a Kathiresan, Sekar4 aut |
710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
772 | 1 8 | i channel recordw 19753896 |
773 | 0 8 | i Värdpublikationt Journal of the American College of Cardiologyg 69:7, 823-836x 0735-1097 |
856 | 4 0 | u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-318961 |
856 | 4 0 | u http://dx.doi.org/10.1016/j.jacc.2016.11.056 |
856 | 4 0 | u http://uu.diva-portal.org/smash/get/diva2:1085599/FULLTEXT01 |
841 | 5 APISa x ab 170330||0000|||||001||||||000000e 1 | |
024 | 7 | 5 APISa urn:nbn:se:uu:diva-3189612 urn |
852 | 5 APISb APIS | |
856 | 4 0 | 5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-318961 |
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