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Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Berndt, Sonja I. (author)
Gustafsson, Stefan (author)
Maegi, Reedik (author)
show more...
Ganna, Andrea (author)
Wheeler, Eleanor (author)
Feitosa, Mary F. (author)
Justice, Anne E. (author)
Monda, Keri L. (author)
Croteau-Chonka, Damien C. (author)
Day, Felix R. (author)
Esko, Tonu (author)
Fall, Tove (author)
Ferreira, Teresa (author)
Gentilini, Davide (author)
Jackson, Anne U. (author)
Luan, Jian'an (author)
Randall, Joshua C. (author)
Vedantam, Sailaja (author)
Willer, Cristen J. (author)
Winkler, Thomas W. (author)
Wood, Andrew R. (author)
Workalemahu, Tsegaselassie (author)
Hu, Yi-Juan (author)
Lee, Sang Hong (author)
Liang, Liming (author)
Lin, Dan-Yu (author)
Min, Josine L. (author)
Neale, Benjamin M. (author)
Thorleifsson, Gudmar (author)
Yang, Jian (author)
Albrecht, Eva (author)
Amin, Najaf (author)
Bragg-Gresham, Jennifer L. (author)
Cadby, Gemma (author)
den Heijer, Martin (author)
Eklund, Niina (author)
Fischer, Krista (author)
Goel, Anuj (author)
Hottenga, Jouke-Jan (author)
Huffman, Jennifer E. (author)
Jarick, Ivonne (author)
Johansson, Åsa (author)
Johnson, Toby (author)
Kanoni, Stavroula (author)
Kleber, Marcus E. (author)
Koenig, Inke R. (author)
Kristiansson, Kati (author)
Kutalik, Zoltn (author)
Lamina, Claudia (author)
Lecoeur, Cecile (author)
Li, Guo (author)
Mangino, Massimo (author)
McArdle, Wendy L. (author)
Medina-Gomez, Carolina (author)
Mueller-Nurasyid, Martina (author)
Ngwa, Julius S. (author)
Nolte, Ilja M. (author)
Paternoster, Lavinia (author)
Pechlivanis, Sonali (author)
Perola, Markus (author)
Peters, Marjolein J. (author)
Preuss, Michael (author)
Rose, Lynda M. (author)
Shi, Jianxin (author)
Shungin, Dmitry (author)
Smith, Albert Vernon (author)
Strawbridge, Rona J. (author)
Surakka, Ida (author)
Teumer, Alexander (author)
Trip, Mieke D. (author)
Tyrer, Jonathan (author)
Van Vliet-Ostaptchouk, Jana V. (author)
Vandenput, Liesbeth (author)
Waite, Lindsay L. (author)
Zhao, Jing Hua (author)
Absher, Devin (author)
Asselbergs, Folkert W. (author)
Atalay, Mustafa (author)
Attwood, Antony P. (author)
Balmforth, Anthony J. (author)
Basart, Hanneke (author)
Beilby, John (author)
Bonnycastle, Lori L. (author)
Brambilla, Paolo (author)
Bruinenberg, Marcel (author)
Campbell, Harry (author)
Chasman, Daniel I. (author)
Chines, Peter S. (author)
Collins, Francis S. (author)
Connell, John M. (author)
Cookson, William O. (author)
de Faire, Ulf (author)
de Vegt, Femmie (author)
Dei, Mariano (author)
Dimitriou, Maria (author)
Edkins, Sarah (author)
Estrada, Karol (author)
Evans, David M. (author)
Farrall, Martin (author)
Ferrario, Marco M. (author)
Ferrieres, Jean (author)
Franke, Lude (author)
Frau, Francesca (author)
Gejman, Pablo V. (author)
Grallert, Harald (author)
Groenberg, Henrik (author)
Gudnason, Vilmundur (author)
Hall, Alistair S. (author)
Hall, Per (author)
Hartikainen, Anna-Liisa (author)
Hayward, Caroline (author)
Heard-Costa, Nancy L. (author)
Heath, Andrew C. (author)
Hebebrand, Johannes (author)
Homuth, Georg (author)
Hu, Frank B. (author)
Hunt, Sarah E. (author)
Hyppoenen, Elina (author)
Iribarren, Carlos (author)
Jacobs, Kevin B. (author)
Jansson, John-Olov (author)
Jula, Antti (author)
Kahonen, Mika (author)
Kathiresan, Sekar (author)
Kee, Frank (author)
Khaw, Kay-Tee (author)
Kivimaki, Mika (author)
Koenig, Wolfgang (author)
Kraja, Aldi T. (author)
Kumari, Meena (author)
Kuulasmaa, Kari (author)
Kuusisto, Johanna (author)
Laitinen, Jaana H. (author)
Lakka, Timo A. (author)
Langenberg, Claudia (author)
Launer, Lenore J. (author)
Lind, Lars (author)
Lindstrom, Jaana (author)
Liu, Jianjun (author)
Liuzzi, Antonio (author)
Lokki, Marja-Liisa (author)
Lorentzon, Mattias (author)
Madden, Pamela A. (author)
Magnusson, Patrik K. (author)
Manunta, Paolo (author)
Marek, Diana (author)
Maerz, Winfried (author)
Leach, Irene Mateo (author)
McKnight, Barbara (author)
Medland, Sarah E. (author)
Mihailov, Evelin (author)
Milani, Lili (author)
Montgomery, Grant W. (author)
Mooser, Vincent (author)
Muehleisen, Thomas W. (author)
Munroe, Patricia B. (author)
Musk, Arthur W. (author)
Narisu, Narisu (author)
Navis, Gerjan (author)
Nicholson, George (author)
Nohr, Ellen A. (author)
Ong, Ken K. (author)
Oostra, Ben A. (author)
Palmer, Colin N. A. (author)
Palotie, Aarno (author)
Peden, John F. (author)
Pedersen, Nancy (author)
Peters, Annette (author)
Polasek, Ozren (author)
Pouta, Anneli (author)
Pramstaller, Peter P. (author)
Prokopenko, Inga (author)
Puetter, Carolin (author)
Radhakrishnan, Aparna (author)
Raitakari, Olli (author)
Rendon, Augusto (author)
Rivadeneira, Fernando (author)
Rudan, Igor (author)
Saaristo, Timo E. (author)
Sambrook, Jennifer G. (author)
Sanders, Alan R. (author)
Sanna, Serena (author)
Saramies, Jouko (author)
Schipf, Sabine (author)
Schreiber, Stefan (author)
Schunkert, Heribert (author)
Shin, So-Youn (author)
Signorini, Stefano (author)
Sinisalo, Juha (author)
Skrobek, Boris (author)
Soranzo, Nicole (author)
Stancakova, Alena (author)
Stark, Klaus (author)
Stephens, Jonathan C. (author)
Stirrups, Kathleen (author)
Stolk, Ronald P. (author)
Stumvoll, Michael (author)
Swift, Amy J. (author)
Theodoraki, Eirini V. (author)
Thorand, Barbara (author)
Tregouet, David-Alexandre (author)
Tremoli, Elena (author)
Van der Klauw, Melanie M. (author)
van Meurs, Joyce B. J. (author)
Vermeulen, Sita H. (author)
Viikari, Jorma (author)
Virtamo, Jarmo (author)
Vitart, Veronique (author)
Waeber, Gerard (author)
Wang, Zhaoming (author)
Widen, Elisabeth (author)
Wild, Sarah H. (author)
Willemsen, Gonneke (author)
Winkelmann, Bernhard R. (author)
Witteman, Jacqueline C. M. (author)
Wolffenbuttel, Bruce H. R. (author)
Wong, Andrew (author)
Wright, Alan F. (author)
Zillikens, M. Carola (author)
Amouyel, Philippe (author)
Boehm, Bernhard O. (author)
Boerwinkle, Eric (author)
Boomsma, Dorret I. (author)
Caulfield, Mark J. (author)
Chanock, Stephen J. (author)
Cupples, L. Adrienne (author)
Cusi, Daniele (author)
Dedoussis, George V. (author)
Erdmann, Jeanette (author)
Eriksson, Johan G. (author)
Franks, Paul W. (author)
Froguel, Philippe (author)
Gieger, Christian (author)
Gyllensten, Ulf (author)
Hamsten, Anders (author)
Harris, Tamara B. (author)
Hengstenberg, Christian (author)
Hicks, Andrew A. (author)
Hingorani, Aroon (author)
Hinney, Anke (author)
Hofman, Albert (author)
Hovingh, Kees G. (author)
Hveem, Kristian (author)
Illig, Thomas (author)
Jarvelin, Marjo-Riitta (author)
Joeckel, Karl-Heinz (author)
Keinanen-Kiukaanniemi, Sirkka M. (author)
Kiemeney, Lambertus A. (author)
Kuh, Diana (author)
Laakso, Markku (author)
Lehtimaki, Terho (author)
Levinson, Douglas F. (author)
Martin, Nicholas G. (author)
Metspalu, Andres (author)
Morris, Andrew D. (author)
Nieminen, Markku S. (author)
Njolstad, Inger (author)
Ohlsson, Claes (author)
Oldehinkel, Albertine J. (author)
Ouwehand, Willem H. (author)
Palmer, Lyle J. (author)
Penninx, Brenda (author)
Power, Chris (author)
Province, Michael A. (author)
Psaty, Bruce M. (author)
Qi, Lu (author)
Rauramaa, Rainer (author)
Ridker, Paul M. (author)
Ripatti, Samuli (author)
Salomaa, Veikko (author)
Samani, Nilesh J. (author)
Snieder, Harold (author)
Sorensen, Thorkild I. A. (author)
Spector, Timothy D. (author)
Stefansson, Kari (author)
Tonjes, Anke (author)
Tuomilehto, Jaakko (author)
Uitterlinden, Andre G. (author)
Uusitupa, Matti (author)
van der Harst, Pim (author)
Vollenweider, Peter (author)
Wallaschofski, Henri (author)
Wareham, Nicholas J. (author)
Watkins, Hugh (author)
Wichmann, H-Erich (author)
Wilson, James F. (author)
Abecasis, Goncalo R. (author)
Assimes, Themistocles L. (author)
Barroso, Ines (author)
Boehnke, Michael (author)
Borecki, Ingrid B. (author)
Deloukas, Panos (author)
Fox, Caroline S. (author)
Frayling, Timothy (author)
Groop, Leif C. (author)
Haritunian, Talin (author)
Heid, Iris M. (author)
Hunter, David (author)
Kaplan, Robert C. (author)
Karpe, Fredrik (author)
Moffatt, Miriam F. (author)
Mohlke, Karen L. (author)
O'Connell, Jeffrey R. (author)
Pawitan, Yudi (author)
Schadt, Eric E. (author)
Schlessinger, David (author)
Steinthorsdottir, Valgerdur (author)
Strachan, David P. (author)
Thorsteinsdottir, Unnur (author)
van Duijn, Cornelia M. (author)
Visscher, Peter M. (author)
Di Blasio, Anna Maria (author)
Hirschhorn, Joel N. (author)
Lindgren, Cecilia M. (author)
Morris, Andrew P. (author)
Meyre, David (author)
Scherag, Andr (author)
McCarthy, Mark I. (author)
Speliotes, Elizabeth K. (author)
North, Kari E. (author)
Loos, Ruth J. F. (author)
Ingelsson, Erik (author)
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2013
2013
English.
In: Nature Genetics. - 1061-4036. ; 45:5, 501-U69
  • swepub:Mat__t
Abstract Subject headings
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  • Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10⁻⁹ to P = 1.8 × 10⁻⁴⁰) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 × 10⁻³ to P = 1.2 × 10⁻¹³). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Physiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Keyword

MEDICINE
MEDICIN

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By the author/editor
Berndt, Sonja I.
Gustafsson, Stef ...
Maegi, Reedik
Ganna, Andrea
Wheeler, Eleanor
Feitosa, Mary F.
show more...
Justice, Anne E.
Monda, Keri L.
Croteau-Chonka, ...
Day, Felix R.
Esko, Tonu
Fall, Tove
Ferreira, Teresa
Gentilini, David ...
Jackson, Anne U.
Luan, Jian'an
Randall, Joshua ...
Vedantam, Sailaj ...
Willer, Cristen ...
Winkler, Thomas ...
Wood, Andrew R.
Workalemahu, Tse ...
Hu, Yi-Juan
Lee, Sang Hong
Liang, Liming
Lin, Dan-Yu
Min, Josine L.
Neale, Benjamin ...
Thorleifsson, Gu ...
Yang, Jian
Albrecht, Eva
Amin, Najaf
Bragg-Gresham, J ...
Cadby, Gemma
den Heijer, Mart ...
Eklund, Niina
Fischer, Krista
Goel, Anuj
Hottenga, Jouke- ...
Huffman, Jennife ...
Jarick, Ivonne
Johansson, Åsa
Johnson, Toby
Kanoni, Stavroul ...
Kleber, Marcus E ...
Koenig, Inke R.
Kristiansson, Ka ...
Kutalik, Zoltn
Lamina, Claudia
Lecoeur, Cecile
Li, Guo
Mangino, Massimo
McArdle, Wendy L ...
Medina-Gomez, Ca ...
Mueller-Nurasyid ...
Ngwa, Julius S.
Nolte, Ilja M.
Paternoster, Lav ...
Pechlivanis, Son ...
Perola, Markus
Peters, Marjolei ...
Preuss, Michael
Rose, Lynda M.
Shi, Jianxin
Shungin, Dmitry
Smith, Albert Ve ...
Strawbridge, Ron ...
Surakka, Ida
Teumer, Alexande ...
Trip, Mieke D.
Tyrer, Jonathan
Van Vliet-Ostapt ...
Vandenput, Liesb ...
Waite, Lindsay L ...
Zhao, Jing Hua
Absher, Devin
Asselbergs, Folk ...
Atalay, Mustafa
Attwood, Antony ...
Balmforth, Antho ...
Basart, Hanneke
Beilby, John
Bonnycastle, Lor ...
Brambilla, Paolo
Bruinenberg, Mar ...
Campbell, Harry
Chasman, Daniel ...
Chines, Peter S.
Collins, Francis ...
Connell, John M.
Cookson, William ...
de Faire, Ulf
de Vegt, Femmie
Dei, Mariano
Dimitriou, Maria
Edkins, Sarah
Estrada, Karol
Evans, David M.
Farrall, Martin
Ferrario, Marco ...
Ferrieres, Jean
Franke, Lude
Frau, Francesca
Gejman, Pablo V.
Grallert, Harald
Groenberg, Henri ...
Gudnason, Vilmun ...
Hall, Alistair S ...
Hall, Per
Hartikainen, Ann ...
Hayward, Carolin ...
Heard-Costa, Nan ...
Heath, Andrew C.
Hebebrand, Johan ...
Homuth, Georg
Hu, Frank B.
Hunt, Sarah E.
Hyppoenen, Elina
Iribarren, Carlo ...
Jacobs, Kevin B.
Jansson, John-Ol ...
Jula, Antti
Kahonen, Mika
Kathiresan, Seka ...
Kee, Frank
Khaw, Kay-Tee
Kivimaki, Mika
Koenig, Wolfgang
Kraja, Aldi T.
Kumari, Meena
Kuulasmaa, Kari
Kuusisto, Johann ...
Laitinen, Jaana ...
Lakka, Timo A.
Langenberg, Clau ...
Launer, Lenore J ...
Lind, Lars
Lindstrom, Jaana
Liu, Jianjun
Liuzzi, Antonio
Lokki, Marja-Lii ...
Lorentzon, Matti ...
Madden, Pamela A ...
Magnusson, Patri ...
Manunta, Paolo
Marek, Diana
Maerz, Winfried
Leach, Irene Mat ...
McKnight, Barbar ...
Medland, Sarah E ...
Mihailov, Evelin
Milani, Lili
Montgomery, Gran ...
Mooser, Vincent
Muehleisen, Thom ...
Munroe, Patricia ...
Musk, Arthur W.
Narisu, Narisu
Navis, Gerjan
Nicholson, Georg ...
Nohr, Ellen A.
Ong, Ken K.
Oostra, Ben A.
Palmer, Colin N. ...
Palotie, Aarno
Peden, John F.
Pedersen, Nancy
Peters, Annette
Polasek, Ozren
Pouta, Anneli
Pramstaller, Pet ...
Prokopenko, Inga
Puetter, Carolin
Radhakrishnan, A ...
Raitakari, Olli
Rendon, Augusto
Rivadeneira, Fer ...
Rudan, Igor
Saaristo, Timo E ...
Sambrook, Jennif ...
Sanders, Alan R.
Sanna, Serena
Saramies, Jouko
Schipf, Sabine
Schreiber, Stefa ...
Schunkert, Herib ...
Shin, So-Youn
Signorini, Stefa ...
Sinisalo, Juha
Skrobek, Boris
Soranzo, Nicole
Stancakova, Alen ...
Stark, Klaus
Stephens, Jonath ...
Stirrups, Kathle ...
Stolk, Ronald P.
Stumvoll, Michae ...
Swift, Amy J.
Theodoraki, Eiri ...
Thorand, Barbara
Tregouet, David- ...
Tremoli, Elena
Van der Klauw, M ...
van Meurs, Joyce ...
Vermeulen, Sita ...
Viikari, Jorma
Virtamo, Jarmo
Vitart, Veroniqu ...
Waeber, Gerard
Wang, Zhaoming
Widen, Elisabeth
Wild, Sarah H.
Willemsen, Gonne ...
Winkelmann, Bern ...
Witteman, Jacque ...
Wolffenbuttel, B ...
Wong, Andrew
Wright, Alan F.
Zillikens, M. Ca ...
Amouyel, Philipp ...
Boehm, Bernhard ...
Boerwinkle, Eric
Boomsma, Dorret ...
Caulfield, Mark ...
Chanock, Stephen ...
Cupples, L. Adri ...
Cusi, Daniele
Dedoussis, Georg ...
Erdmann, Jeanett ...
Eriksson, Johan ...
Franks, Paul W.
Froguel, Philipp ...
Gieger, Christia ...
Gyllensten, Ulf
Hamsten, Anders
Harris, Tamara B ...
Hengstenberg, Ch ...
Hicks, Andrew A.
Hingorani, Aroon
Hinney, Anke
Hofman, Albert
Hovingh, Kees G.
Hveem, Kristian
Illig, Thomas
Jarvelin, Marjo- ...
Joeckel, Karl-He ...
Keinanen-Kiukaan ...
Kiemeney, Lamber ...
Kuh, Diana
Laakso, Markku
Lehtimaki, Terho
Levinson, Dougla ...
Martin, Nicholas ...
Metspalu, Andres
Morris, Andrew D ...
Nieminen, Markku ...
Njolstad, Inger
Ohlsson, Claes
Oldehinkel, Albe ...
Ouwehand, Willem ...
Palmer, Lyle J.
Penninx, Brenda
Power, Chris
Province, Michae ...
Psaty, Bruce M.
Qi, Lu
Rauramaa, Rainer
Ridker, Paul M.
Ripatti, Samuli
Salomaa, Veikko
Samani, Nilesh J ...
Snieder, Harold
Sorensen, Thorki ...
Spector, Timothy ...
Stefansson, Kari
Tonjes, Anke
Tuomilehto, Jaak ...
Uitterlinden, An ...
Uusitupa, Matti
van der Harst, P ...
Vollenweider, Pe ...
Wallaschofski, H ...
Wareham, Nichola ...
Watkins, Hugh
Wichmann, H-Eric ...
Wilson, James F.
Abecasis, Goncal ...
Assimes, Themist ...
Barroso, Ines
Boehnke, Michael
Borecki, Ingrid ...
Deloukas, Panos
Fox, Caroline S.
Frayling, Timoth ...
Groop, Leif C.
Haritunian, Tali ...
Heid, Iris M.
Hunter, David
Kaplan, Robert C ...
Karpe, Fredrik
Moffatt, Miriam ...
Mohlke, Karen L.
O'Connell, Jeffr ...
Pawitan, Yudi
Schadt, Eric E.
Schlessinger, Da ...
Steinthorsdottir ...
Strachan, David ...
Thorsteinsdottir ...
van Duijn, Corne ...
Visscher, Peter ...
Di Blasio, Anna ...
Hirschhorn, Joel ...
Lindgren, Cecili ...
Morris, Andrew P ...
Meyre, David
Scherag, Andr
McCarthy, Mark I ...
Speliotes, Eliza ...
North, Kari E.
Loos, Ruth J. F.
Ingelsson, Erik
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