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WFRF:(Heit John A)
 

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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003517naa a22005413a 4500
00120194040
003SE-LIBR
00520170323180105.0
007cr||||||||||||
008170323s2015 sw |||| o |||| ||eng c
0247 a http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2671942 uri
0247 a urn:nbn:se:uu:diva-2671942 urn
0247 a 10.1038/srep156702 doi
040 a S
0410 a eng
042 9 EPLK
1001 a Winham, Stacey J.4 aut
2451 0a Associations of prodynorphin sequence variation with alcohol dependence and related traits are phenotype-specific and sex-dependenth [Elektronisk resurs]
260 c 2015
500 a Published
500 a NIH (National Institute of Health) [P20 AA17830Z]
500 a NIH (National Institute of Health) [K12 HD65987]
500 a Vetenskapsrådet
500 a Forskningsrådet Formas
500 a NIH (National Institute of Health) [HG04735]
5060 a gratis
520 a We previously demonstrated that prodynorphin (PDYN) haplotypes and single nucleotide polymorphism (SNP) rs2281285 are associated with alcohol dependence and the propensity to drink in negative emotional states, and recent studies suggest that PDYN gene effects on substance dependence risk may be sex-related. We examined sex-dependent associations of PDYN variation with alcohol dependence and related phenotypes, including negative craving, time until relapse after treatment and the length of sobriety episodes before seeking treatment, in discovery and validation cohorts of European ancestry. We found a significant haplotype-by-sex interaction (p = 0.03), suggesting association with alcohol dependence in males (p = 1E-4) but not females. The rs2281285G allele increased risk for alcohol dependence in males in the discovery cohort (OR = 1.49, p = 0.002), with a similar trend in the validation cohort (OR = 1.35, p = 0.086). However, rs2281285 showed a trend towards association with increased negative craving in females in both the discovery (beta = 10.16, p = 0.045) and validation samples (OR = 7.11, p = 0.066). In the discovery cohort, rs2281285 was associated with time until relapse after treatment in females (HR = 1.72, p = 0.037); in the validation cohort, it was associated with increased length of sobriety episodes before treatment in males (beta = 13.49, p = 0.001). Our findings suggest that sex-dependent effects of PDYN variants in alcohol dependence are phenotype-specific.
650 7a Medical and Health Sciences2 hsv
650 7a Clinical Medicine2 hsv
650 7a Medicin och hälsovetenskap2 hsv
650 7a Klinisk medicin2 hsv
7001 a Preuss, Ulrich W.4 aut
7001 a Geske, Jennifer R.4 aut
7001 a Zill, Peter4 aut
7001 a Heit, John A.4 aut
7001 a Bakalkin, Georgy4 aut
7001 a Biernacka, Joanna M.4 aut
7001 a Karpyak, Victor M.4 aut
7101 2a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl
7721 8i channel recordw 19753896
7730 8i Värdpublikationt Scientific Reportsg 5x 2045-2322
8564 0u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-267194
8564 0u http://dx.doi.org/10.1038/srep15670
8564 0u http://uu.diva-portal.org/smash/get/diva2:872560/FULLTEXT01
841 5 APISa x ab 170323||0000|||||001||||||000000e 1
0247 5 APISa urn:nbn:se:uu:diva-2671942 urn
852 5 APISb APIS
8564 05 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-267194

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