Sökning: WFRF:(Lameyre Valerie) > (2015) > The effect of dosin...
Fältnamn | Indikatorer | Metadata |
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000 | 08371naa a22017653a 4500 | |
001 | 20194308 | |
003 | SE-LIBR | |
005 | 20170323182046.0 | |
007 | cr|||||||||||| | |
008 | 170323s2015 sw |||| o |||| ||eng c | |
024 | 7 | a http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2530812 uri |
024 | 7 | a urn:nbn:se:uu:diva-2530812 urn |
024 | 7 | a 10.1186/s12916-015-0301-z2 doi |
040 | a S | |
041 | 0 | a eng |
042 | 9 EPLK | |
100 | 1 | a Adjuik, Martin A.4 aut |
245 | 1 0 | a The effect of dosing strategies on the therapeutic efficacy of artesunate-amodiaquine for uncomplicated malariah [Elektronisk resurs]b a meta-analysis of individual patient data |
260 | c 2015 | |
500 | a Published | |
506 | 0 | a gratis |
520 | a Background: Artesunate-amodiaquine (AS-AQ) is one of the most widely used artemisinin-based combination therapies (ACTs) to treat uncomplicated Plasmodium falciparum malaria in Africa. We investigated the impact of different dosing strategies on the efficacy of this combination for the treatment of falciparum malaria. Methods: Individual patient data from AS-AQ clinical trials were pooled using the WorldWide Antimalarial Resistance Network (WWARN) standardised methodology. Risk factors for treatment failure were identified using a Cox regression model with shared frailty across study sites. Results: Forty-three studies representing 9,106 treatments from 1999-2012 were included in the analysis; 4,138 (45.4%) treatments were with a fixed dose combination with an AQ target dose of 30 mg/kg (FDC), 1,293 (14.2%) with a non-fixed dose combination with an AQ target dose of 25 mg/kg (loose NFDC-25), 2,418 (26.6%) with a non-fixed dose combination with an AQ target dose of 30 mg/kg (loose NFDC-30), and the remaining 1,257 (13.8%) with a co-blistered non-fixed dose combination with an AQ target dose of 30 mg/kg (co-blistered NFDC). The median dose of AQ administered was 32.1 mg/kg [IQR: 25.9-38.2], the highest dose being administered to patients treated with co-blistered NFDC (median = 35.3 mg/kg [IQR: 30.6-43.7]) and the lowest to those treated with loose NFDC-25 (median = 25.0 mg/kg [IQR: 22.7-25.0]). Patients treated with FDC received a median dose of 32.4 mg/kg [IQR: 27-39.0]. After adjusting for reinfections, the corrected antimalarial efficacy on day 28 after treatment was similar for co-blistered NFDC (97.9% [95% confidence interval (CI): 97.0-98.8%]) and FDC (98.1% [95% CI: 97.6%-98.5%]; P = 0.799), but significantly lower for the loose NFDC-25 (93.4% [95% CI: 91.9%-94.9%]), and loose NFDC-30 (95.0% [95% CI: 94.1%-95.9%]) (P < 0.001 for all comparisons). After controlling for age, AQ dose, baseline parasitemia and region; treatment with loose NFDC-25 was associated with a 3.5-fold greater risk of recrudescence by day 28 (adjusted hazard ratio, AHR = 3.51 [95% CI: 2.02-6.12], P < 0.001) compared to FDC, and treatment with loose NFDC-30 was associated with a higher risk of recrudescence at only three sites. Conclusions: There was substantial variation in the total dose of amodiaquine administered in different AS-AQ combination regimens. Fixed dose AS-AQ combinations ensure optimal dosing and provide higher antimalarial treatment efficacy than the loose individual tablets in all age categories. | |
650 | 7 | a Medical and Health Sciences2 hsv |
650 | 7 | a Clinical Medicine2 hsv |
650 | 7 | a Infectious Medicine2 hsv |
650 | 7 | a Medicin och hälsovetenskap2 hsv |
650 | 7 | a Klinisk medicin2 hsv |
650 | 7 | a Infektionsmedicin2 hsv |
653 | 0 | a Malaria |
653 | 0 | a Plasmodium falciparum |
653 | 0 | a Drug resistance |
653 | 0 | a Artesunate |
653 | 0 | a Amodiaquine |
653 | 0 | a Dosing |
653 | 0 | a Efficacy |
700 | 1 | a Allan, Richard4 aut |
700 | 1 | a Anvikar, Anupkumar R.4 aut |
700 | 1 | a Ashley, Elizabeth A.4 aut |
700 | 1 | a Ba, Mamadou S.4 aut |
700 | 1 | a Barennes, Hubert4 aut |
700 | 1 | a Barnes, Karen I.4 aut |
700 | 1 | a Bassat, Quique4 aut |
700 | 1 | a Baudin, Elisabeth4 aut |
700 | 1 | a Bjorkman, Anders4 aut |
700 | 1 | a Bompart, Francois4 aut |
700 | 1 | a Bonnet, Maryline4 aut |
700 | 1 | a Borrmann, Steffen4 aut |
700 | 1 | a Brasseur, Philippe4 aut |
700 | 1 | a Bukirwa, Hasifa4 aut |
700 | 1 | a Checchi, Francesco4 aut |
700 | 1 | a Cot, Michel4 aut |
700 | 1 | a Dahal, Prabin4 aut |
700 | 1 | a D'Alessandro, Umberto4 aut |
700 | 1 | a Deloron, Philippe4 aut |
700 | 1 | a Desai, Meghna4 aut |
700 | 1 | a Diap, Graciela4 aut |
700 | 1 | a Djimde, Abdoulaye A.4 aut |
700 | 1 | a Dorsey, Grant4 aut |
700 | 1 | a Doumbo, Ogobara K.4 aut |
700 | 1 | a Espie, Emmanuelle4 aut |
700 | 1 | a Etard, Jean-Francois4 aut |
700 | 1 | a Fanello, Caterina I.4 aut |
700 | 1 | a Faucher, Jean-Francois4 aut |
700 | 1 | a Faye, Babacar4 aut |
700 | 1 | a Flegg, Jennifer A.4 aut |
700 | 1 | a Gaye, Oumar4 aut |
700 | 1 | a Gething, Peter W.4 aut |
700 | 1 | a Gonzalez, Raquel4 aut |
700 | 1 | a Grandesso, Francesco4 aut |
700 | 1 | a Guerin, Philippe J.4 aut |
700 | 1 | a Guthmann, Jean-Paul4 aut |
700 | 1 | a Hamour, Sally4 aut |
700 | 1 | a Hasugian, Armedy Ronny4 aut |
700 | 1 | a Hay, Simon I.4 aut |
700 | 1 | a Humphreys, Georgina S.4 aut |
700 | 1 | a Jullien, Vincent4 aut |
700 | 1 | a Juma, Elizabeth4 aut |
700 | 1 | a Kamya, Moses R.4 aut |
700 | 1 | a Karema, Corine4 aut |
700 | 1 | a Kiechel, Jean R.4 aut |
700 | 1 | a Kremsner, Peter G.4 aut |
700 | 1 | a Krishna, Sanjeev4 aut |
700 | 1 | a Lameyre, Valerie4 aut |
700 | 1 | a Ibrahim, Laminou M.4 aut |
700 | 1 | a Lee, Sue J.4 aut |
700 | 1 | a Lell, Bertrand4 aut |
700 | 1 | a Martensson, Andreas4 aut |
700 | 1 | a Massougbodji, Achille4 aut |
700 | 1 | a Menan, Herve4 aut |
700 | 1 | a Menard, Didier4 aut |
700 | 1 | a Menendez, Clara4 aut |
700 | 1 | a Meremikwu, Martin4 aut |
700 | 1 | a Moreira, Clarissa4 aut |
700 | 1 | a Nabasumba, Carolyn4 aut |
700 | 1 | a Nambozi, Michael4 aut |
700 | 1 | a Ndiaye, Jean-Louis4 aut |
700 | 1 | a Nikiema, Frederic4 aut |
700 | 1 | a Nsanzabana, Christian4 aut |
700 | 1 | a Ntoumi, Francine4 aut |
700 | 1 | a Ogutu, Bernhards R.4 aut |
700 | 1 | a Olliaro, Piero4 aut |
700 | 1 | a Osorio, Lyda4 aut |
700 | 1 | a Ouedraogo, Jean-Bosco4 aut |
700 | 1 | a Penali, Louis K.4 aut |
700 | 1 | a Pene, Mbaye4 aut |
700 | 1 | a Pinoges, Loretxu4 aut |
700 | 1 | a Piola, Patrice4 aut |
700 | 1 | a Price, Ric N.4 aut |
700 | 1 | a Roper, Cally4 aut |
700 | 1 | a Rosenthal, Philip J.4 aut |
700 | 1 | a Rwagacondo, Claude Emile4 aut |
700 | 1 | a Same-Ekobo, Albert4 aut |
700 | 1 | a Schramm, Birgit4 aut |
700 | 1 | a Seck, Amadou4 aut |
700 | 1 | a Sharma, Bhawna4 aut |
700 | 1 | a Sibley, Carol Hopkins4 aut |
700 | 1 | a Sinou, Veronique4 aut |
700 | 1 | a Sirima, Sodiomon B.4 aut |
700 | 1 | a Smith, Jeffery J.4 aut |
700 | 1 | a Smithuis, Frank4 aut |
700 | 1 | a Some, Fabrice A.4 aut |
700 | 1 | a Sow, Doudou4 aut |
700 | 1 | a Staedke, Sarah G.4 aut |
700 | 1 | a Stepniewska, Kasia4 aut |
700 | 1 | a Swarthout, Todd D.4 aut |
700 | 1 | a Sylla, Khadime4 aut |
700 | 1 | a Talisuna, Ambrose O.4 aut |
700 | 1 | a Tarning, Joel4 aut |
700 | 1 | a Taylor, Walter R. J.4 aut |
700 | 1 | a Temu, Emmanuel A.4 aut |
700 | 1 | a Thwing, Julie I.4 aut |
700 | 1 | a Tjitra, Emiliana4 aut |
700 | 1 | a Tine, Roger C. K.4 aut |
700 | 1 | a Tinto, Halidou4 aut |
700 | 1 | a Vaillant, Michel T.4 aut |
700 | 1 | a Valecha, Neena4 aut |
700 | 1 | a Van den Broek, Ingrid4 aut |
700 | 1 | a White, Nicholas J.4 aut |
700 | 1 | a Yeka, Adoke4 aut |
700 | 1 | a Zongo, Issaka4 aut |
710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
772 | 1 8 | i channel recordw 19753896 |
773 | 0 8 | i Värdpublikationt BMC Medicineg 13x 1741-7015 |
856 | 4 0 | u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-253081 |
856 | 4 0 | u http://dx.doi.org/10.1186/s12916-015-0301-z |
856 | 4 0 | u http://uu.diva-portal.org/smash/get/diva2:819496/FULLTEXT01 |
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024 | 7 | 5 APISa urn:nbn:se:uu:diva-2530812 urn |
852 | 5 APISb APIS | |
856 | 4 0 | 5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-253081 |
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