WFRF:(Savolainen Markku J.)
Sökning: WFRF:(Savolainen Markku J.) > Effects of a health...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04501naa a22008053a 4500 | |
| 001 | 20193026 | |
| 003 | SE-LIBR | |
| 005 | 20170323164916.0 | |
| 007 | cr|||||||||||| | |
| 008 | 170323s2016 sw |||| o |||| ||eng c | |
| 024 | 7 | a http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2866582 uri |
| 024 | 7 | a urn:nbn:se:uu:diva-2866582 urn |
| 024 | 7 | a 10.1186/s12263-016-0521-42 doi |
| 040 | a S | |
| 041 | 0 | a eng |
| 042 | 9 EPLK | |
| 100 | 1 | a Leder, Lena4 aut |
| 245 | 1 0 | a Effects of a healthy Nordic diet on gene expression changes in peripheral blood mononuclear cells in response to an oral glucose tolerance test in subjects with metabolic syndromeh [Elektronisk resurs]b a SYSDIET sub-study |
| 260 | c 2016 | |
| 500 | a Published | |
| 500 | a Vetenskapsrådet | |
| 500 | a Diabetesförbundet | |
| 500 | a Hjärt-Lungfonden | |
| 506 | 0 | a gratis |
| 520 | a Background: Diet has a great impact on the risk of developing features of metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), and cardiovascular diseases (CVD). We evaluated whether a long-term healthy Nordic diet (ND) can modify the expression of inflammation and lipid metabolism-related genes in peripheral blood mononuclear cells (PBMCs) during a 2-h oral glucose tolerance test (OGTT) in individuals with MetS. Methods: A Nordic multicenter randomized dietary study included subjects (n = 213) with MetS, randomized to a ND group or a control diet (CD) group applying an isocaloric study protocol. In this sub-study, we included subjects (n = 89) from three Nordic centers: Kuopio (n = 26), Lund (n = 30), and Oulu (n = 33) with a maximum weight change of +/- 4 kg, high-sensitivity C-reactive protein concentration <= 10 mg L-1, and baseline body mass index <39 kg m(-2). PBMCs were isolated, and the mRNA gene expression analysis was measured by quantitative real-time polymerase chain reaction (qPCR). We analyzed the mRNA expression changes of 44 genes before and after a 2hOGTT at the beginning and the end of the intervention. Results: The healthy ND significantly down-regulated the expression of toll-like receptor 4 (TLR4), interleukin 18 (IL18), and thrombospondin receptor (CD36) mRNA transcripts and significantly up-regulated the expression of peroxisome proliferator-activated receptor delta (PPARD) mRNA transcript after the 2hOGTT compared to the CD. Conclusions: A healthy ND is able to modify the gene expression in PBMCs after a 2hOGTT. However, more studies are needed to clarify the biological and clinical relevance of these findings. | |
| 650 | 7 | a Medical and Health Sciences2 hsv |
| 650 | 7 | a Health Sciences2 hsv |
| 650 | 7 | a Medicin och hälsovetenskap2 hsv |
| 650 | 7 | a Hälsovetenskaper2 hsv |
| 653 | 0 | a mRNA gene expression |
| 653 | 0 | a Metabolic syndrome |
| 653 | 0 | a PBMCs |
| 653 | 0 | a Nordic diet |
| 653 | 0 | a OGTT |
| 700 | 1 | a Kolehmainen, Marjukka4 aut |
| 700 | 1 | a Narverud, Ingunn4 aut |
| 700 | 1 | a Dahlman, Ingrid4 aut |
| 700 | 1 | a Myhrstad, Mari C. W.4 aut |
| 700 | 1 | a de Mello, Vanessa D.4 aut |
| 700 | 1 | a Paananen, Jussi4 aut |
| 700 | 1 | a Carlberg, Carsten4 aut |
| 700 | 1 | a Schwab, Ursula4 aut |
| 700 | 1 | a Herzig, Karl-Heinz4 aut |
| 700 | 1 | a Cloetens, Lieselotte4 aut |
| 700 | 1 | a Storm, Matilda Ulmius4 aut |
| 700 | 1 | a Hukkanen, Janne4 aut |
| 700 | 1 | a Savolainen, Markku J.4 aut |
| 700 | 1 | a Rosqvist, Fredrik4 aut |
| 700 | 1 | a Hermansen, Kjeld4 aut |
| 700 | 1 | a Dragsted, Lars O.4 aut |
| 700 | 1 | a Gunnarsdottir, Ingibjorg4 aut |
| 700 | 1 | a Thorsdottir, Inga4 aut |
| 700 | 1 | a Riserus, Ulf4 aut |
| 700 | 1 | a Akesson, Bjorn4 aut |
| 700 | 1 | a Thoresen, Magne4 aut |
| 700 | 1 | a Arner, Peter4 aut |
| 700 | 1 | a Poutanen, Kaisa S.4 aut |
| 700 | 1 | a Uusitupa, Matti4 aut |
| 700 | 1 | a Holven, Kirsten B.4 aut |
| 700 | 1 | a Ulven, Stine M.4 aut |
| 710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
| 772 | 1 8 | i channel recordw 19753896 |
| 773 | 0 8 | i Värdpublikationt Genes & Nutritiong 11:1x 1555-8932 |
| 856 | 4 0 | u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-286658 |
| 856 | 4 0 | u http://dx.doi.org/10.1186/s12263-016-0521-4 |
| 856 | 4 0 | u http://uu.diva-portal.org/smash/get/diva2:923693/FULLTEXT01 |
| 841 | 5 APISa x ab 170323||0000|||||001||||||000000e 1 | |
| 024 | 7 | 5 APISa urn:nbn:se:uu:diva-2866582 urn |
| 852 | 5 APISb APIS | |
| 856 | 4 0 | 5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-286658 |
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