WFRF:(Silverman Debra T.)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 07550naa a22019093a 4500 | |
| 001 | 22487824 | |
| 003 | SE-LIBR | |
| 005 | 20180306095844.0 | |
| 007 | cr|||||||||||| | |
| 008 | 180306s2018 sw |||| o |||| ||eng c | |
| 024 | 7 | a http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1451382 uri |
| 024 | 7 | a urn:nbn:se:umu:diva-1451382 urn |
| 024 | 7 | a 10.1038/s41467-018-02942-52 doi |
| 040 | a S | |
| 041 | 0 | a eng |
| 042 | 9 EPLK | |
| 100 | 1 | a Klein, Alison P.4 aut |
| 245 | 1 0 | a Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancerh [Elektronisk resurs] |
| 260 | b Nature Publishing Groupc 2018 | |
| 500 | a Published | |
| 506 | 0 | a gratis |
| 520 | a In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P = 4.35 x 10(-8)). Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PAN-DoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P = 8.36 x 10(-14)), rs2941471 at 8q21.11 (HNF4G, P = 6.60 x 10(-10)), rs4795218 at 17q12 (HNF1B, P = 1.32 x 10(-8)), and rs1517037 at 18q21.32 (GRP, P = 3.28 x 10(-8)). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA. Expression quantitative trait locus analysis in three independent pancreatic data sets provides molecular support of NOC2L as a pancreatic cancer susceptibility gene. | |
| 650 | 7 | a Medical and Health Sciences2 hsv |
| 650 | 7 | a Clinical Medicine2 hsv |
| 650 | 7 | a Cancer and Oncology2 hsv |
| 650 | 7 | a Medicin och hälsovetenskap2 hsv |
| 650 | 7 | a Klinisk medicin2 hsv |
| 650 | 7 | a Cancer och onkologi2 hsv |
| 700 | 1 | a Wolpin, Brian M.4 aut |
| 700 | 1 | a Risch, Harvey A.4 aut |
| 700 | 1 | a Stolzenberg-Solomon, Rachael Z.4 aut |
| 700 | 1 | a Mocci, Evelina4 aut |
| 700 | 1 | a Zhang, Mingfeng4 aut |
| 700 | 1 | a Canzian, Federico4 aut |
| 700 | 1 | a Childs, Erica J.4 aut |
| 700 | 1 | a Hoskins, Jason W.4 aut |
| 700 | 1 | a Jermusyk, Ashley4 aut |
| 700 | 1 | a Zhong, Jun4 aut |
| 700 | 1 | a Chen, Fei4 aut |
| 700 | 1 | a Albanes, Demetrius4 aut |
| 700 | 1 | a Andreotti, Gabriella4 aut |
| 700 | 1 | a Arslan, Alan A.4 aut |
| 700 | 1 | a Babic, Ana4 aut |
| 700 | 1 | a Bamlet, William R.4 aut |
| 700 | 1 | a Beane-Freeman, Laura4 aut |
| 700 | 1 | a Berndt, Sonja I.4 aut |
| 700 | 1 | a Blackford, Amanda4 aut |
| 700 | 1 | a Borges, Michael4 aut |
| 700 | 1 | a Borgida, Ayelet4 aut |
| 700 | 1 | a Bracci, Paige M.4 aut |
| 700 | 1 | a Brais, Lauren4 aut |
| 700 | 1 | a Brennan, Paul4 aut |
| 700 | 1 | a Brenner, Hermann4 aut |
| 700 | 1 | a Bueno-de-Mesquita, Bas4 aut |
| 700 | 1 | a Buring, Julie4 aut |
| 700 | 1 | a Campa, Daniele4 aut |
| 700 | 1 | a Capurso, Gabriele4 aut |
| 700 | 1 | a Cavestro, Giulia Martina4 aut |
| 700 | 1 | a Chaffee, Kari G.4 aut |
| 700 | 1 | a Chung, Charles C.4 aut |
| 700 | 1 | a Cleary, Sean4 aut |
| 700 | 1 | a Cotterchio, Michelle4 aut |
| 700 | 1 | a Dijk, Frederike4 aut |
| 700 | 1 | a Duell, Eric J.4 aut |
| 700 | 1 | a Foretova, Lenka4 aut |
| 700 | 1 | a Fuchs, Charles4 aut |
| 700 | 1 | a Funel, Niccola4 aut |
| 700 | 1 | a Gallinger, Steven4 aut |
| 700 | 1 | a Gaziano, J. Michael M.4 aut |
| 700 | 1 | a Gazouli, Maria4 aut |
| 700 | 1 | a Giles, Graham G.4 aut |
| 700 | 1 | a Giovannucci, Edward4 aut |
| 700 | 1 | a Goggins, Michael4 aut |
| 700 | 1 | a Goodman, Gary E.4 aut |
| 700 | 1 | a Goodman, Phyllis J.4 aut |
| 700 | 1 | a Hackert, Thilo4 aut |
| 700 | 1 | a Haiman, Christopher4 aut |
| 700 | 1 | a Hartge, Patricia4 aut |
| 700 | 1 | a Hasan, Manal4 aut |
| 700 | 1 | a Hegyi, Peter4 aut |
| 700 | 1 | a Helzlsouer, Kathy J.4 aut |
| 700 | 1 | a Herman, Joseph4 aut |
| 700 | 1 | a Holcatova, Ivana4 aut |
| 700 | 1 | a Holly, Elizabeth A.4 aut |
| 700 | 1 | a Hoover, Robert4 aut |
| 700 | 1 | a Hung, Rayjean J.4 aut |
| 700 | 1 | a Jacobs, Eric J.4 aut |
| 700 | 1 | a Jamroziak, Krzysztof4 aut |
| 700 | 1 | a Janout, Vladimir4 aut |
| 700 | 1 | a Kaaks, Rudolf4 aut |
| 700 | 1 | a Khaw, Kay-Tee4 aut |
| 700 | 1 | a Klein, Eric A.4 aut |
| 700 | 1 | a Kogevinas, Manolis4 aut |
| 700 | 1 | a Kooperberg, Charles4 aut |
| 700 | 1 | a Kulke, Matthew H.4 aut |
| 700 | 1 | a Kupcinskas, Juozas4 aut |
| 700 | 1 | a Kurtz, Robert J.4 aut |
| 700 | 1 | a Laheru, Daniel4 aut |
| 700 | 1 | a Landi, Stefano4 aut |
| 700 | 1 | a Lawlor, Rita T.4 aut |
| 700 | 1 | a Lee, I. -Min4 aut |
| 700 | 1 | a LeMarchand, Loic4 aut |
| 700 | 1 | a Lu, Lingeng4 aut |
| 700 | 1 | a Malats, Nuria4 aut |
| 700 | 1 | a Mambrini, Andrea4 aut |
| 700 | 1 | a Mannisto, Satu4 aut |
| 700 | 1 | a Milne, Roger L.4 aut |
| 700 | 1 | a Mohelnikova-Duchonova, Beatrice4 aut |
| 700 | 1 | a Neale, Rachel E.4 aut |
| 700 | 1 | a Neoptolemos, John P.4 aut |
| 700 | 1 | a Oberg, Ann L.4 aut |
| 700 | 1 | a Olson, Sara H.4 aut |
| 700 | 1 | a Orlow, Irene4 aut |
| 700 | 1 | a Pasquali, Claudio4 aut |
| 700 | 1 | a Patel, Alpa V.4 aut |
| 700 | 1 | a Peters, Ulrike4 aut |
| 700 | 1 | a Pezzilli, Raffaele4 aut |
| 700 | 1 | a Porta, Miquel4 aut |
| 700 | 1 | a Real, Francisco X.4 aut |
| 700 | 1 | a Rothman, Nathaniel4 aut |
| 700 | 1 | a Scelo, Ghislaine4 aut |
| 700 | 1 | a Sesso, Howard D.4 aut |
| 700 | 1 | a Severi, Gianluca4 aut |
| 700 | 1 | a Shu, Xiao-Ou4 aut |
| 700 | 1 | a Silverman, Debra4 aut |
| 700 | 1 | a Smith, Jill P.4 aut |
| 700 | 1 | a Soucek, Pavel4 aut |
| 700 | 1 | a Sund, Malin4 aut |
| 700 | 1 | a Talar-Wojnarowska, Renata4 aut |
| 700 | 1 | a Tavano, Francesca4 aut |
| 700 | 1 | a Thornquist, Mark D.4 aut |
| 700 | 1 | a Tobias, Geoffrey S.4 aut |
| 700 | 1 | a Van Den Eeden, Stephen K.4 aut |
| 700 | 1 | a Vashist, Yogesh4 aut |
| 700 | 1 | a Visvanathan, Kala4 aut |
| 700 | 1 | a Vodicka, Pavel4 aut |
| 700 | 1 | a Wactawski-Wende, Jean4 aut |
| 700 | 1 | a Wang, Zhaoming4 aut |
| 700 | 1 | a Wentzensen, Nicolas4 aut |
| 700 | 1 | a White, Emily4 aut |
| 700 | 1 | a Yu, Herbert4 aut |
| 700 | 1 | a Yu, Kai4 aut |
| 700 | 1 | a Zeleniuch-Jacquotte, Anne4 aut |
| 700 | 1 | a Zheng, Wei4 aut |
| 700 | 1 | a Kraft, Peter4 aut |
| 700 | 1 | a Li, Donghui4 aut |
| 700 | 1 | a Chanock, Stephen4 aut |
| 700 | 1 | a Obazee, Ofure4 aut |
| 700 | 1 | a Petersen, Gloria M.4 aut |
| 700 | 1 | a Amundadottir, Laufey T.4 aut |
| 710 | 1 2 | a Umeå universitetb Medicinska fakulteten4 pbl0 268483 |
| 772 | 1 8 | i channel recordw 18813935 |
| 773 | 0 8 | i Värdpublikationt Nature Communicationsg 9x 2041-1723 |
| 856 | 4 0 | u http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-145138 |
| 856 | 4 0 | u http://dx.doi.org/10.1038/s41467-018-02942-5 |
| 856 | 4 0 | u http://umu.diva-portal.org/smash/get/diva2:1187691/FULLTEXT01 |
| 910 | 2 s | 6 710a Umeå universitet.b Medicinsk-odontologiska fakultetenu Umeå universitet.b Medicinska fakulteten |
| 910 | 2 s | 6 710a Medicinska fakulteten vid Umeå universitetu Umeå universitet.b Medicinska fakulteten |
| 841 | 5 APISa x ab 180306||0000|||||001||||||000000e 1 | |
| 024 | 7 | 5 APISa urn:nbn:se:umu:diva-1451382 urn |
| 852 | 5 APISb APIS | |
| 856 | 4 0 | 5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-145138 |
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- Av författaren/redakt...
- Klein, Alison P.
- Wolpin, Brian M.
- Risch, Harvey A.
- Stolzenberg-Solo ...
- Mocci, Evelina
- Zhang, Mingfeng
- visa fler...
- Canzian, Federic ...
- Childs, Erica J.
- Hoskins, Jason W ...
- Jermusyk, Ashley
- Zhong, Jun
- Chen, Fei
- Albanes, Demetri ...
- Andreotti, Gabri ...
- Arslan, Alan A.
- Babic, Ana
- Bamlet, William ...
- Beane-Freeman, L ...
- Berndt, Sonja I.
- Blackford, Amand ...
- Borges, Michael
- Borgida, Ayelet
- Bracci, Paige M.
- Brais, Lauren
- Brennan, Paul
- Brenner, Hermann
- Bueno-de-Mesquit ...
- Buring, Julie
- Campa, Daniele
- Capurso, Gabriel ...
- Cavestro, Giulia ...
- Chaffee, Kari G.
- Chung, Charles C ...
- Cleary, Sean
- Cotterchio, Mich ...
- Dijk, Frederike
- Duell, Eric J.
- Foretova, Lenka
- Fuchs, Charles
- Funel, Niccola
- Gallinger, Steve ...
- Gaziano, J. Mich ...
- Gazouli, Maria
- Giles, Graham G.
- Giovannucci, Edw ...
- Goggins, Michael
- Goodman, Gary E.
- Goodman, Phyllis ...
- Hackert, Thilo
- Haiman, Christop ...
- Hartge, Patricia
- Hasan, Manal
- Hegyi, Peter
- Helzlsouer, Kath ...
- Herman, Joseph
- Holcatova, Ivana
- Holly, Elizabeth ...
- Hoover, Robert
- Hung, Rayjean J.
- Jacobs, Eric J.
- Jamroziak, Krzys ...
- Janout, Vladimir
- Kaaks, Rudolf
- Khaw, Kay-Tee
- Klein, Eric A.
- Kogevinas, Manol ...
- Kooperberg, Char ...
- Kulke, Matthew H ...
- Kupcinskas, Juoz ...
- Kurtz, Robert J.
- Laheru, Daniel
- Landi, Stefano
- Lawlor, Rita T.
- Lee, I. -Min
- LeMarchand, Loic
- Lu, Lingeng
- Malats, Nuria
- Mambrini, Andrea
- Mannisto, Satu
- Milne, Roger L.
- Mohelnikova-Duch ...
- Neale, Rachel E.
- Neoptolemos, Joh ...
- Oberg, Ann L.
- Olson, Sara H.
- Orlow, Irene
- Pasquali, Claudi ...
- Patel, Alpa V.
- Peters, Ulrike
- Pezzilli, Raffae ...
- Porta, Miquel
- Real, Francisco ...
- Rothman, Nathani ...
- Scelo, Ghislaine
- Sesso, Howard D.
- Severi, Gianluca
- Shu, Xiao-Ou
- Silverman, Debra
- Smith, Jill P.
- Soucek, Pavel
- Sund, Malin
- Talar-Wojnarowsk ...
- Tavano, Francesc ...
- Thornquist, Mark ...
- Tobias, Geoffrey ...
- Van Den Eeden, S ...
- Vashist, Yogesh
- Visvanathan, Kal ...
- Vodicka, Pavel
- Wactawski-Wende, ...
- Wang, Zhaoming
- Wentzensen, Nico ...
- White, Emily
- Yu, Herbert
- Yu, Kai
- Zeleniuch-Jacquo ...
- Zheng, Wei
- Kraft, Peter
- Li, Donghui
- Chanock, Stephen
- Obazee, Ofure
- Petersen, Gloria ...
- Amundadottir, La ...
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