WFRF:(Rosenquist Richard)
Sökning: WFRF:(Rosenquist Richard) > A comprehensive eva...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04498naa a22006733a 4500 | |
| 001 | 22067821 | |
| 003 | SE-LIBR | |
| 005 | 20171206152742.0 | |
| 007 | cr|||||||||||| | |
| 008 | 171206s2014 sw |||| o |||| ||eng c | |
| 024 | 7 | a http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2385752 uri |
| 024 | 7 | a urn:nbn:se:uu:diva-2385752 urn |
| 024 | 7 | a 10.1186/s12881-014-0113-62 doi |
| 040 | a S | |
| 041 | 0 | a eng |
| 042 | 9 EPLK | |
| 100 | 1 | a Baecklund, Fredrik4 aut |
| 245 | 1 0 | a A comprehensive evaluation of the role of genetic variation in follicular lymphoma survivalh [Elektronisk resurs] |
| 260 | c 2014 | |
| 500 | a Published | |
| 506 | 0 | a gratis |
| 520 | a Background: Survival in follicular lymphoma (FL) is highly variable, even within prognostic groups defined by tumor grade and the Follicular Lymphoma International Prognostic Index. Studies suggest that germline single nucleotide polymorphisms (SNPs) may hold prognostic information but further investigation is needed. Methods: We explored the association between SNPs and FL outcome using two approaches: 1) Two independent genome-wide association studies (GWAS) of similar to 300.000 SNPs followed by a meta-analysis encompassing 586 FL patients diagnosed in Denmark/Sweden 1999-2002 and in the United States 2001-2006; and 2) Investigation of 22 candidate-gene variants previously associated with FL outcome in the Danish/Swedish cohort (N = 373). We estimated time to lymphoma-specific death (approach 1 and 2) and lymphoma progression (approach 2) with hazard ratios (HR) and 95% confidence intervals (CI) in a multivariable Cox regression model. Results: In the GWAS meta-analysis, using a random effects model, no variants were associated with lymphoma-specific death at a genome-wide significant level (p < 5.0x10(-8)). The strongest association was observed for tightly linked SNPs on 17q24 near the ABCA10 and ABCA6 genes (rs10491178 HRrandom = 3.17, 95% CI 2.09-4.79, prandom = 5.24x10(-8)). The ABCA10 and ABCA6 genes belong to a family of genes encoding for ABC transporter proteins, implicated in multidrug resistance. In line with a previous study, rs2466571 in CD46 (HR = 0.73, 95% CI 0.58-0.91, p = 0.006) showed nominal association with lymphoma progression, as did two highly linked SNPs in IL8 (rs4073 HR = 0.78, 95% CI 0.62-0.97, p = 0.02; rs2227307 HR = 0.75, 95% CI 0.60-0.94, p = 0.01) previously associated with overall survival. Conclusions: The results suggest a possible role for multidrug resistance in FL survival and add to the evidence that genetic variation in CD46 and IL8 may have prognostic implications in FL. Our findings need further confirmation in other independent populations or in a larger multicenter GWAS. | |
| 650 | 7 | a Medical and Health Sciences2 hsv |
| 650 | 7 | a Clinical Medicine2 hsv |
| 650 | 7 | a Cancer and Oncology2 hsv |
| 650 | 7 | a Medicin och hälsovetenskap2 hsv |
| 650 | 7 | a Klinisk medicin2 hsv |
| 650 | 7 | a Cancer och onkologi2 hsv |
| 653 | 0 | a Follicular lymphoma |
| 653 | 0 | a Prognosis |
| 653 | 0 | a Single nucleotide polymorphism |
| 653 | 0 | a Genome-wide association study |
| 653 | 0 | a Candidate gene study |
| 700 | 1 | a Foo, Jia-Nee4 aut |
| 700 | 1 | a Bracci, Paige4 aut |
| 700 | 1 | a Darabi, Hatef4 aut |
| 700 | 1 | a Karlsson, Robert4 aut |
| 700 | 1 | a Hjalgrim, Henrik4 aut |
| 700 | 1 | a Rosenquist Brandell, Richard4 aut |
| 700 | 1 | a Adami, Hans-Olov4 aut |
| 700 | 1 | a Glimelius, Bengt4 aut |
| 700 | 1 | a Melbye, Mads4 aut |
| 700 | 1 | a Conde, Lucia4 aut |
| 700 | 1 | a Liu, Jianjun4 aut |
| 700 | 1 | a Humphreys, Keith4 aut |
| 700 | 1 | a Skibola, Christine F.4 aut |
| 700 | 1 | a Smedby, Karin E.4 aut |
| 710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
| 710 | 1 2 | a Uppsala universitetb Science for Life Laboratory, SciLifeLab4 pbl |
| 710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
| 772 | 1 8 | i channel recordw 19753896 |
| 773 | 0 8 | i Värdpublikationt BMC Medical Geneticsg 15, 113x 1471-2350 |
| 856 | 4 0 | u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-238575 |
| 856 | 4 0 | u http://dx.doi.org/10.1186/s12881-014-0113-6 |
| 856 | 4 0 | u http://uu.diva-portal.org/smash/get/diva2:772386/FULLTEXT01 |
| 841 | 5 APISa x ab 171206||0000|||||001||||||000000e 1 | |
| 024 | 7 | 5 APISa urn:nbn:se:uu:diva-2385752 urn |
| 852 | 5 APISb APIS | |
| 856 | 4 0 | 5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-238575 |
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