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WFRF:(Armstrong Georgina N)
 

Sökning: WFRF:(Armstrong Georgina N) > Glioma-related seiz...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004437naa a22007693a 4500
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003SE-LIBR
00520180531113918.0
007cr||||||||||||
008180531s2018 sw |||| o |||| ||eng c
024a http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3493792 uri
024a urn:nbn:se:uu:diva-3493792 urn
024a 10.1007/s00415-018-8857-02 doi
040 a S
041a eng
042 9 EPLK
100a Berntsson, Shala G.d 1964-4 aut
2451 0a Glioma-related seizures in relation to histopathological subtypesh [Elektronisk resurs]b a report from the glioma international case-control study.
260 c 2018
500 a Epub ahead of print
506a gratis
520 a BACKGROUND: The purpose of this study was to evaluate the distribution of glioma-related seizures and seizure control at the time of tumor diagnosis with respect to tumor histologic subtypes, tumor treatment and patient characteristics, and to compare seizure history preceding tumor diagnosis (or study enrollment) between glioma patients and healthy controls. METHODS: The Glioma International Case Control study (GICC) risk factor questionnaire collected information on demographics, past medical/medication history, and occupational history. Cases from eight centers were also asked detailed questions on seizures in relation to glioma diagnosis; cases (n = 4533) and controls (n = 4171) were also asked about seizures less than 2 years from diagnosis and previous seizure history more than 2 years prior to tumor diagnosis, including childhood seizures. RESULTS: Low-grade gliomas (LGGs), particularly oligodendrogliomas/oligoastrocytomas, had the highest proportion of glioma-related seizures. Patients with low-grade astrocytoma demonstrated the most medically refractory seizures. A total of 83% of patients were using only one antiepileptic drug (AED), which was levetiracetam in 71% of cases. Gross total resection was strongly associated with reduced seizure frequency (p < 0.009). No significant difference was found between glioma cases and controls in terms of seizure occurring more than 2 years before diagnosis or during childhood. CONCLUSIONS: Our study showed that glioma-related seizures were most common in low-grade gliomas. Gross total resection was associated with lower seizure frequency. Additionally, having a history of childhood seizures is not a risk factor ***for developing glioma-related seizures or glioma.
650 7a Medical and Health Sciences2 hsv
650 7a Clinical Medicine2 hsv
650 7a Neurology2 hsv
650 7a Medicin och hälsovetenskap2 hsv
650 7a Klinisk medicin2 hsv
650 7a Neurologi2 hsv
653 0a Epileptic seizures
653 0a Glioma-related seizures
653 0a Observational study (cohort
653 0a case–control)
653 0a Primary brain tumor
700a Merrell, Ryan T4 aut
700a Amirian, E Susan4 aut
700a Armstrong, Georgina N4 aut
700a Lachance, Daniel4 aut
700a Smits, Anja4 aut
700a Zhou, Renke4 aut
700a Jacobs, Daniel I4 aut
700a Wrensch, Margaret R4 aut
700a Olson, Sara H4 aut
700a Il'yasova, Dora4 aut
700a Claus, Elizabeth B4 aut
700a Barnholtz-Sloan, Jill S4 aut
700a Schildkraut, Joellen4 aut
700a Sadetzki, Siegal4 aut
700a Johansen, Christoffer4 aut
700a Houlston, Richard S4 aut
700a Jenkins, Robert B4 aut
700a Bernstein, Jonine L4 aut
700a Lai, Rose4 aut
700a Shete, Sanjay4 aut
700a Amos, Christopher I4 aut
700a Bondy, Melissa L4 aut
700a Melin, Beatrice S4 aut
7101 2a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl
710a Neurology4 oth
7721 8i channel recordw 19753896
7730 8i Värdpublikationt Journal of Neurologyx 0340-5354
8564 0u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-349379
8564 0u http://dx.doi.org/10.1007/s00415-018-8857-0
8564 0u http://uu.diva-portal.org/smash/get/diva2:1201573/FULLTEXT01
841 5 APISa x ab 180531||0000|||||001||||||000000e 1
0245 APISa urn:nbn:se:uu:diva-3493792 urn
852 5 APISb APIS
8564 05 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-349379

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