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Dietary Intake of F...
Dietary Intake of Flavonoids and Ventilatory Function in European Adults A GA²LEN Study
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Garcia-Larsen, Vanessa (author)
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Thawer, Narjis (author)
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Charles, David (author)
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Cassidy, Aedin (author)
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van Zele, Thibaut (author)
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Thilsing, Trine (author)
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Ahlström, Matti (author)
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Haahtela, Tari (author)
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Keil, Thomas (author)
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Matricardi, Paolo M (author)
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Brożek, Grzegorz (author)
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Kowalski, Marek L (author)
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Makowska, Joanna (author)
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Niżankowska-Mogilnicka, Ewa (author)
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Rymarczyk, Barbara (author)
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Loureiro, Carlos (author)
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Todo Bom, Ana (author)
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Bachert, Claus (author)
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Forsberg, Bertil (author)
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Janson, Christer (author)
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Torén, Kjell (author)
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Potts, James F (author)
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Burney, Peter Gj (author)
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(publisher)
- MDPI AG 2018
- 2018
- English.
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In: Nutrients. - 2072-6643. ; 10:1
Abstract
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- BACKGROUND: Flavonoids exert anti-inflammatory properties and modulate oxidative stress in vitro, suggesting a protective effect on lung function, but epidemiological studies examining this association are scarce. METHODS: A stratified random sample was drawn from the GA²LEN screening survey, in which 55,000 adults aged 15 to 75 answered a questionnaire on respiratory symptoms. Post-bronchodilator spirometry was obtained from 2850 subjects. Forced vital capacity (FVC), the ratio between the forced exhaled volume in 1 second (FEV₁) and FVC (FEV₁/FVC), FVC below lower limit of normal (FVC < LLN), and FEV₁/FVC < LLN were calculated. Intake of the six main subclasses of flavonoids was estimated using the GA²LEN Food Frequency Questionnaire. Adjusted associations between outcomes and each subclass of flavonoids were examined with multivariate regressions. Simes' procedure was used to test for multiple comparisons. RESULTS: A total of 2599 subjects had valid lung function and dietary data. A lower prevalence of FVC < LLN (airway restriction) was observed in those with higher total flavonoid (adjusted odds ratio (aOR), higher vs. lowest quintile intake 0.58; 95% Confidence Interval (CI) 0.36, 0.94), and pro-anthocyanidin intakes (aOR 0.47; 95% CI 0.27, 0.81). A higher FEV₁/FVC was associated with higher intakes of total flavonoids and pro-anthocyanidins (adjusted correlation coefficient (a β-coeff 0.33; 0.10, 0.57 and a β-coeff 0.44; 95% CI 0.19, 0.69, respectively). After Simes' procedure, the statistical significance of each of these associations was attenuated but remained below 0.05, with the exception of total flavonoids and airway restriction. CONCLUSIONS: This population-based study in European adults provides cross-sectional evidence of a positive association of total flavonoid intake and pro-anthocyanidins and ventilatory function, and a negative association with spirometric restriction in European adults.
Subject headings
- Medical and Health Sciences (hsv)
- Health Sciences (hsv)
- Nutrition and Dietetics (hsv)
- Medicin och hälsovetenskap (hsv)
- Hälsovetenskaper (hsv)
- Näringslära (hsv)
Keyword
- flavonoids
- pro-anthocyanidins
- lung function
- GA2LEN
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- By the author/editor
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Garcia-Larsen, V ...
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Thawer, Narjis
-
Charles, David
-
Cassidy, Aedin
-
van Zele, Thibau ...
-
Thilsing, Trine
-
show more...
-
Ahlström, Matti
-
Haahtela, Tari
-
Keil, Thomas
-
Matricardi, Paol ...
-
Brożek, Grzegor ...
-
Kowalski, Marek ...
-
Makowska, Joanna
-
Niżankowska-Mog ...
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Rymarczyk, Barba ...
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Loureiro, Carlos
-
Todo Bom, Ana
-
Bachert, Claus
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Forsberg, Bertil
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Janson, Christer
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Torén, Kjell
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Potts, James F
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Burney, Peter Gj
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show less...
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