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  • Szummer, Karolina (författare)

Time in therapeutic range and outcomes after warfarin initiation in newly diagnosed atrial fibrillation patients with renal dysfunction

  • E-artikel/E-kapitelEngelska2017

Förlag, utgivningsår, omfång ...

  • 2017

Nummerbeteckningar

  • LIBRIS-ID:20142866
  • http://urn.kb.se/resolve?urn=urn:nbn:se:du-24516uri
  • urn:nbn:se:du-24516urn
  • 10.1161/JAHA.116.004925doi

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  • Språk:engelska

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Anmärkningar

  • Published
  • gratis
  • BACKGROUND: It is unknown whether renal dysfunction conveys poor anticoagulation control in warfarin-treated patients with atrial fibrillation and whether poor anticoagulation control associates with the risk of adverse outcomes in these patients. METHODS AND RESULTS: This was an observational study from the Stockholm CREatinine Measurements (SCREAM) cohort including all newly diagnosed atrial fibrillation patients initiating treatment with warfarin (n=7738) in Stockholm, Sweden, between 2006 and 2011. Estimated glomerular filtration rate (eGFR; mL/min per 1.73 m(2)) was calculated from serum creatinine. Time-in-therapeutic range (TTR) was assessed from international normalized ratio (INR) measurements up to warfarin cessation, adverse event, or end of follow-up (2 years). Adverse events considered a composite of intracranial hemorrhage, ischemic stroke, myocardial infarction, or death. During median 254 days, TTR was 83%, based on median 21 INR measurements per patient. TTR was 70% among patients with eGFR <30, around 10% lower than in those with normal renal function. During observation, adverse events occurred in 4.0% of patients, and those with TTR ≤75% were at higher adverse event risk. This was independent of patient characteristics, comorbidities, number of INR tests, days exposed to warfarin, and, notably, independent of eGFR: adjusted odds ratio (OR) 1.84 (95% CI, 1.41-2.40) for TTR 75% to 60% and adjusted OR 2.09 (1.59-2.74) for TTR <60%. No interaction was observed between eGFR and TTR in association to adverse events (P=0.2). CONCLUSION: Severe chronic kidney disease (eGFR <30) patients with atrial fibrillation have worse INR control while on warfarin. An optimal TTR (>75%) is associated with lower risk of adverse events, independently of underlying renal function.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Gasparini, Alessandro (författare)
  • Eliasson, Staffan (författare)
  • Ärnlöv, Johan (författare)
  • Qureshi, Abdul Rashid (författare)
  • Bárány, Peter (författare)
  • Evans, Marie (författare)
  • Friberg, Leif (författare)
  • Carrero, Juan Jesus (författare)
  • Högskolan DalarnaAkademin Utbildning, hälsa och samhälle (utgivare)

Sammanhörande titlar

  • Del av/supplement till:channel record
  • Ingår i:VärdpublikationJournal of the American Heart Association6:32047-9980

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