SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Carrero Juan Jesus)
 

Sökning: WFRF:(Carrero Juan Jesus) > Time in therapeutic...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003891naa a22005893a 4500
00120142866
003SE-LIBR
00520170312063327.0
007cr||||||||||||
008170312s2017 sw |||| o |||| ||eng c
0247 a http://urn.kb.se/resolve?urn=urn:nbn:se:du-245162 uri
0247 a urn:nbn:se:du-245162 urn
0247 a 10.1161/JAHA.116.0049252 doi
040 a S
0410 a eng
042 9 EPLK
1001 a Szummer, Karolina4 aut
2451 0a Time in therapeutic range and outcomes after warfarin initiation in newly diagnosed atrial fibrillation patients with renal dysfunctionh [Elektronisk resurs]
260 c 2017
500 a Published
5060 a gratis
520 a BACKGROUND: It is unknown whether renal dysfunction conveys poor anticoagulation control in warfarin-treated patients with atrial fibrillation and whether poor anticoagulation control associates with the risk of adverse outcomes in these patients. METHODS AND RESULTS: This was an observational study from the Stockholm CREatinine Measurements (SCREAM) cohort including all newly diagnosed atrial fibrillation patients initiating treatment with warfarin (n=7738) in Stockholm, Sweden, between 2006 and 2011. Estimated glomerular filtration rate (eGFR; mL/min per 1.73 m(2)) was calculated from serum creatinine. Time-in-therapeutic range (TTR) was assessed from international normalized ratio (INR) measurements up to warfarin cessation, adverse event, or end of follow-up (2 years). Adverse events considered a composite of intracranial hemorrhage, ischemic stroke, myocardial infarction, or death. During median 254 days, TTR was 83%, based on median 21 INR measurements per patient. TTR was 70% among patients with eGFR <30, around 10% lower than in those with normal renal function. During observation, adverse events occurred in 4.0% of patients, and those with TTR ≤75% were at higher adverse event risk. This was independent of patient characteristics, comorbidities, number of INR tests, days exposed to warfarin, and, notably, independent of eGFR: adjusted odds ratio (OR) 1.84 (95% CI, 1.41-2.40) for TTR 75% to 60% and adjusted OR 2.09 (1.59-2.74) for TTR <60%. No interaction was observed between eGFR and TTR in association to adverse events (P=0.2). CONCLUSION: Severe chronic kidney disease (eGFR <30) patients with atrial fibrillation have worse INR control while on warfarin. An optimal TTR (>75%) is associated with lower risk of adverse events, independently of underlying renal function.
650 7a Medical and Health Sciences2 hsv
650 7a Clinical Medicine2 hsv
650 7a Medicin och hälsovetenskap2 hsv
650 7a Klinisk medicin2 hsv
650 7a Health and Welfare2 du
650 7a Hälsa och välfärd2 du
653 0a all‐cause death
653 0a anticoagulant
653 0a atrial fibrillation
653 0a bleeding
653 0a ischemic stroke
653 0a renal function
7001 a Gasparini, Alessandro4 aut
7001 a Eliasson, Staffan4 aut
7001 a Ärnlöv, Johan4 aut
7001 a Qureshi, Abdul Rashid4 aut
7001 a Bárány, Peter4 aut
7001 a Evans, Marie4 aut
7001 a Friberg, Leif4 aut
7001 a Carrero, Juan Jesus4 aut
7101 2a Högskolan Dalarnab Akademin Utbildning, hälsa och samhälle4 pbl
7721 8i channel recordw 18775397
7730 8i Värdpublikationt Journal of the American Heart Associationg 6:3x 2047-9980
8564 0u http://urn.kb.se/resolve?urn=urn:nbn:se:du-24516
8564 0u http://dx.doi.org/10.1161/JAHA.116.004925
8564 0u http://du.diva-portal.org/smash/get/diva2:1079864/FULLTEXT01
841 5 APISa x ab 170312||0000|||||001||||||000000e 1
0247 5 APISa urn:nbn:se:du-245162 urn
852 5 APISb APIS
8564 05 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:du-24516

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy