WFRF:(Halayko Andrew J.)
Sökning: WFRF:(Halayko Andrew J.) > Statin-triggered ce...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04410naa a22007333a 4500 | |
| 001 | 22103638 | |
| 003 | SE-LIBR | |
| 005 | 20171211175336.0 | |
| 007 | cr|||||||||||| | |
| 008 | 171211s2010 sw |||| o |||| ||eng c | |
| 024 | 7 | a http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-868612 uri |
| 024 | 7 | a urn:nbn:se:liu:diva-868612 urn |
| 024 | 7 | a 10.1016/j.bbamcr.2009.12.0052 doi |
| 040 | a S | |
| 041 | 0 | a eng |
| 042 | 9 EPLK | |
| 100 | 1 | a Ghavami, Saeid4 aut |
| 245 | 1 0 | a Statin-triggered cell death in primary human lung mesenchyrnal cells involves p53-PUMA and release of Smac and Omi but not cytochrome ch [Elektronisk resurs] |
| 260 | b Elsevierc 2010 | |
| 500 | a Published | |
| 506 | 0 | a gratis |
| 520 | a Statins inhibit 3-hydroxy-3-methyl-glutarylcoenzyme CoA (HMG-CoA) reductase, the proximal enzyme forcholesterol biosynthesis. They exhibit pleiotropic effects and are linked to health benefits for diseasesincluding cancer and lung disease. Understanding their mechanism of action could point to new therapies,thus we investigated the response of primary cultured human airway mesenchymal cells, which play aneffector role in asthma and chronic obstructive lung disease (COPD), to simvastatin exposure. Simvastatininduced apoptosis involving caspase-9, -3 and -7, but not caspase-8 in airway smooth muscle cells andfibroblasts. HMG-CoA inhibition did not alter cellular cholesterol content but did abrogate de novocholesterol synthesis. Pro-apoptotic effects were prevented by exogenous mevalonate, geranylgeranylpyrophosphate and farnesyl pyrophosphate, downstream products of HMG-CoA. Simvastatin increasedexpression of Bax, oligomerization of Bax and Bak, and expression of BH3-only p53-dependent genes, PUMAand NOXA. Inhibition of p53 and silencing of p53 unregulated modulator of apoptosis (PUMA) expressionpartly counteracted simvastatin-induced cell death, suggesting a role for p53-independent mechanisms.Simvastatin did not induce mitochondrial release of cytochrome c, but did promote release of inhibitor ofapoptosis (IAP) proteins, Smac and Omi. Simvastatin also inhibited mitochondrial fission with the loss ofmitochondrial Drp1, an essential component of mitochondrial fission machinery. Thus, simvastatin activatesnovel apoptosis pathways in lung mesenchymal cells involving p53, IAP inhibitor release, and disruption ofmitochondrial fission. | |
| 650 | 7 | a Natural Sciences2 hsv |
| 650 | 7 | a Biological Sciences2 hsv |
| 650 | 7 | a Biochemistry and Molecular Biology2 hsv |
| 650 | 7 | a Naturvetenskap2 hsv0 264446 |
| 650 | 7 | a Biologiska vetenskaper2 hsv |
| 650 | 7 | a Biokemi och molekylärbiologi2 hsv |
| 650 | 7 | a Cell Biology2 hsv |
| 650 | 7 | a Cellbiologi2 hsv |
| 653 | 0 | a Apoptosis Statin Caspase Airway smooth muscle Fibroblast Mitochondria |
| 700 | 1 | a Mutawe, Mark M.4 aut |
| 700 | 1 | a Hauff, Kristin4 aut |
| 700 | 1 | a Stelmack, Gerald L.4 aut |
| 700 | 1 | a Schaafsma, Dedmer4 aut |
| 700 | 1 | a Sharma, Pawan4 aut |
| 700 | 1 | a McNeill, Karol D.4 aut |
| 700 | 1 | a Hynes, Tyler S.4 aut |
| 700 | 1 | a Kung, Sam K.4 aut |
| 700 | 1 | a Unruh, Helmut4 aut |
| 700 | 1 | a Klonisch, Thomas4 aut |
| 700 | 1 | a Hatch, Grant M.4 aut |
| 700 | 1 | a Los, Marek Jan4 aut |
| 700 | 1 | a Halayko, Andrew J.4 aut |
| 772 | 1 8 | i channel recordw 18478042 |
| 773 | 0 8 | i Värdpublikationt Biochimica et Biophysica Actag 1803:4, 452-467x 0006-3002 |
| 856 | 4 0 | u http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-86861 |
| 856 | 4 0 | u http://dx.doi.org/10.1016/j.bbamcr.2009.12.005 |
| 856 | 4 0 | u http://liu.diva-portal.org/smash/get/diva2:582963/FULLTEXT01 |
| 950 | k | 6 650a Atomerw hu Naturvetenskap |
| 950 | k | 6 650a Experimentw hu Naturvetenskap |
| 950 | k | 6 650a Fysikw hu Naturvetenskap |
| 950 | k | 6 650a Kemiw hu Naturvetenskap |
| 950 | k | 6 650a Kloningw hu Naturvetenskap |
| 950 | k | 6 650a Laboratorierw hu Naturvetenskap |
| 950 | k | 6 650a Marinbiologiw hu Naturvetenskap |
| 950 | k | 6 650a Matematikw hu Naturvetenskap |
| 950 | k | 6 650a Medicinska experimentw hu Naturvetenskap |
| 950 | k | 6 650a Tyngdlagenw hu Naturvetenskap |
| 950 | k | 6 650a Utvecklingsläraw hu Naturvetenskap |
| 841 | 5 APISa x ab 171211||0000|||||001||||||000000e 1 | |
| 024 | 7 | 5 APISa urn:nbn:se:liu:diva-868612 urn |
| 852 | 5 APISb APIS | |
| 856 | 4 0 | 5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-86861 |
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- Ghavami, Saeid
- Mutawe, Mark M.
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