WFRF:(Carrero Juan Jesus)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04716naa a22006493a 4500 | |
| 001 | 22431674 | |
| 003 | SE-LIBR | |
| 005 | 20180213095752.0 | |
| 007 | cr|||||||||||| | |
| 008 | 180213s2017 sw |||| o |||| ||eng c | |
| 024 | 7 | a http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1443572 uri |
| 024 | 7 | a urn:nbn:se:liu:diva-1443572 urn |
| 024 | 7 | a 10.1136/openhrt-2016-0005682 doi |
| 040 | a S | |
| 041 | 0 | a eng |
| 042 | 9 EPLK | |
| 100 | 1 | a Szummer, Karolina4 aut |
| 245 | 1 0 | a Comparison of the Chronic Kidney Disease Epidemiology Collaboration, the Modification of Diet in Renal Disease study and the Cockcroft-Gault equation in patients with heart failureh [Elektronisk resurs] |
| 260 | a Gateshead, United Kingdomb Open House International Associationc 2017 | |
| 500 | a Published | |
| 506 | 0 | a gratis |
| 520 | a BACKGROUND: It is unknown how the creatinine-based renal function estimations differ for dose adjustment cut-offs and risk prediction in patients with heart failure. METHOD AND RESULTS: The renal function was similar with the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) (median 59 mL/min/1.73 m2, IQR 42 to 77) and Modification of Diet in Renal Disease Study (MDRD) (59 mL/min/1.73 m2, IQR 43 to 75) and slightly lower with the Cockcroft-Gault (CG) equation (57 mL/min, IQR 39 to 82). Across the commonly used renal function stages, the CKD-EPI and the MDRD classified patients into the same stage in 87.2% (kappa coefficient 0.83, p<0.001); the CKD-EPI and the CG equation agreed in 52.3% (kappa coefficient 0.39, p<0.001). Hence, a differing number of patients will receive dose adjustment depending on which formula is used as cut-off. The CG equation predicted worse prognosis better (c-statistics 0.740, 95% CI 0.734 to 0.746) than CKD-EPI (0.697, 95% CI 0.690 to 0.703, p<0.001) and MDRD (0.680, 95% CI 0.734 to 0.746). Using net reclassification improvement (NRI), the CG identified 12.8% more patients at higher risk of death as compared with the CKD-EPI equation. Patients registered in the Swedish Heart Failure Registry (n= 40 736) with standardised creatinine values between 2000 and 2012 had their renal function estimated with the CKD-EPI, the MDRD and the CG. Agreement between the formulas was compared for categories. Prediction of death was assessed with c-statistics and with NRI. CONCLUSION: The choice of renal function estimation formula has clinical implications and differing results at various cut-off levels. For prognosis, the CG predicts mortality better than the CKD-EPI and MDRD. | |
| 650 | 7 | a Medical and Health Sciences2 hsv |
| 650 | 7 | a Clinical Medicine2 hsv |
| 650 | 7 | a Cardiac and Cardiovascular Systems2 hsv |
| 650 | 7 | a Medicin och hälsovetenskap2 hsv |
| 650 | 7 | a Klinisk medicin2 hsv |
| 650 | 7 | a Kardiologi2 hsv |
| 653 | 0 | a application |
| 653 | 0 | a creatinine |
| 653 | 0 | a heart failure |
| 653 | 0 | a prognosis |
| 653 | 0 | a register |
| 653 | 0 | a renal function estimation |
| 700 | 1 | a Evans, Marie4 aut |
| 700 | 1 | a Carrero, Juan Jesus4 aut |
| 700 | 1 | a Alehagen, Urband 1951-4 aut0 228339 |
| 700 | 1 | a Dahlström, Ulfd 1946-4 aut0 409195 |
| 700 | 1 | a Benson, Lina4 aut |
| 700 | 1 | a Lund, Lars H4 aut |
| 710 | 1 2 | a Linköpings universitetb Institutionen för medicin och hälsa4 pbl0 308697 |
| 710 | 1 2 | a Linköpings universitetb Medicinska fakulteten4 pbl |
| 710 | 1 2 | a Region Östergötlandb Hjärt- och Medicincentrum4 pbl |
| 772 | 1 8 | i channel recordw 18478042 |
| 773 | 0 8 | i Värdpublikationt Open heartg 4:2x 0168-2601 |
| 856 | 4 0 | u http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-144357 |
| 856 | 4 0 | u http://dx.doi.org/10.1136/openhrt-2016-000568 |
| 856 | 4 0 | u http://liu.diva-portal.org/smash/get/diva2:1174714/FULLTEXT01 |
| 910 | 2 s | 6 710a IMHu Linköpings universitet.b Institutionen för medicin och hälsa |
| 910 | 2 s | 6 710i Engelska:a Linköping Universty.b Department of Medical and Health Sciencesw iu Linköpings universitet.b Institutionen för medicin och hälsa |
| 910 | 2 s | 6 710a Linköping Universty.b Department of Medicine and Health Sciencesu Linköpings universitet.b Institutionen för medicin och hälsa |
| 910 | 2 k | 6 710a Linköpings universitet.b Institutionen för hälsa och samhälleu Linköpings universitet.b Institutionen för medicin och hälsa |
| 910 | 2 k | 6 710a Linköpings universitet.b Institutionen för medicin och vårdu Linköpings universitet.b Institutionen för medicin och hälsa |
| 841 | 5 APISa x ab 180214||0000|||||001||||||000000e 1 | |
| 024 | 7 | 5 APISa urn:nbn:se:liu:diva-1443572 urn |
| 852 | 5 APISb APIS | |
| 856 | 4 0 | 5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-144357 |
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