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|---|---|---|
| 000 | 15100naa a22042973a 4500 | |
| 001 | 22081409 | |
| 003 | SE-LIBR | |
| 005 | 20171207153125.0 | |
| 007 | cr|||||||||||| | |
| 008 | 171207s2013 sw |||| o |||| ||eng c | |
| 024 | 7 | a http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2006752 uri |
| 024 | 7 | a urn:nbn:se:uu:diva-2006752 urn |
| 024 | 7 | a 10.1038/ng.26062 doi |
| 040 | a S | |
| 041 | 0 | a eng |
| 042 | 9 EPLK | |
| 100 | 1 | a Berndt, Sonja I.4 aut |
| 245 | 1 0 | a Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architectureh [Elektronisk resurs] |
| 260 | c 2013 | |
| 500 | a Published | |
| 506 | 0 | a gratis |
| 520 | a Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups. | |
| 650 | 7 | a Medical and Health Sciences2 hsv |
| 650 | 7 | a Medicin och hälsovetenskap2 hsv |
| 700 | 1 | a Gustafsson, Stefan4 aut |
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| 700 | 1 | a Ganna, Andrea4 aut |
| 700 | 1 | a Wheeler, Eleanor4 aut |
| 700 | 1 | a Feitosa, Mary F.4 aut |
| 700 | 1 | a Justice, Anne E.4 aut |
| 700 | 1 | a Monda, Keri L.4 aut |
| 700 | 1 | a Croteau-Chonka, Damien C.4 aut |
| 700 | 1 | a Day, Felix R.4 aut |
| 700 | 1 | a Esko, Tonu4 aut |
| 700 | 1 | a Fall, Tove4 aut |
| 700 | 1 | a Ferreira, Teresa4 aut |
| 700 | 1 | a Gentilini, Davide4 aut |
| 700 | 1 | a Jackson, Anne U.4 aut |
| 700 | 1 | a Luan, Jian'an4 aut |
| 700 | 1 | a Randall, Joshua C.4 aut |
| 700 | 1 | a Vedantam, Sailaja4 aut |
| 700 | 1 | a Willer, Cristen J.4 aut |
| 700 | 1 | a Winkler, Thomas W.4 aut |
| 700 | 1 | a Wood, Andrew R.4 aut |
| 700 | 1 | a Workalemahu, Tsegaselassie4 aut |
| 700 | 1 | a Hu, Yi-Juan4 aut |
| 700 | 1 | a Lee, Sang Hong4 aut |
| 700 | 1 | a Liang, Liming4 aut |
| 700 | 1 | a Lin, Dan-Yu4 aut |
| 700 | 1 | a Min, Josine L.4 aut |
| 700 | 1 | a Neale, Benjamin M.4 aut |
| 700 | 1 | a Thorleifsson, Gudmar4 aut |
| 700 | 1 | a Yang, Jian4 aut |
| 700 | 1 | a Albrecht, Eva4 aut |
| 700 | 1 | a Amin, Najaf4 aut |
| 700 | 1 | a Bragg-Gresham, Jennifer L.4 aut |
| 700 | 1 | a Cadby, Gemma4 aut |
| 700 | 1 | a den Heijer, Martin4 aut |
| 700 | 1 | a Eklund, Niina4 aut |
| 700 | 1 | a Fischer, Krista4 aut |
| 700 | 1 | a Goel, Anuj4 aut |
| 700 | 1 | a Hottenga, Jouke-Jan4 aut |
| 700 | 1 | a Huffman, Jennifer E.4 aut |
| 700 | 1 | a Jarick, Ivonne4 aut |
| 700 | 1 | a Johansson, Åsa4 aut0 320150 |
| 700 | 1 | a Johnson, Toby4 aut |
| 700 | 1 | a Kanoni, Stavroula4 aut |
| 700 | 1 | a Kleber, Marcus E.4 aut |
| 700 | 1 | a Koenig, Inke R.4 aut |
| 700 | 1 | a Kristiansson, Kati4 aut |
| 700 | 1 | a Kutalik, Zoltn4 aut |
| 700 | 1 | a Lamina, Claudia4 aut |
| 700 | 1 | a Lecoeur, Cecile4 aut |
| 700 | 1 | a Li, Guo4 aut |
| 700 | 1 | a Mangino, Massimo4 aut |
| 700 | 1 | a McArdle, Wendy L.4 aut |
| 700 | 1 | a Medina-Gomez, Carolina4 aut |
| 700 | 1 | a Mueller-Nurasyid, Martina4 aut |
| 700 | 1 | a Ngwa, Julius S.4 aut |
| 700 | 1 | a Nolte, Ilja M.4 aut |
| 700 | 1 | a Paternoster, Lavinia4 aut |
| 700 | 1 | a Pechlivanis, Sonali4 aut |
| 700 | 1 | a Perola, Markus4 aut |
| 700 | 1 | a Peters, Marjolein J.4 aut |
| 700 | 1 | a Preuss, Michael4 aut |
| 700 | 1 | a Rose, Lynda M.4 aut |
| 700 | 1 | a Shi, Jianxin4 aut |
| 700 | 1 | a Shungin, Dmitry4 aut |
| 700 | 1 | a Smith, Albert Vernon4 aut |
| 700 | 1 | a Strawbridge, Rona J.4 aut |
| 700 | 1 | a Surakka, Ida4 aut |
| 700 | 1 | a Teumer, Alexander4 aut |
| 700 | 1 | a Trip, Mieke D.4 aut |
| 700 | 1 | a Tyrer, Jonathan4 aut |
| 700 | 1 | a Van Vliet-Ostaptchouk, Jana V.4 aut |
| 700 | 1 | a Vandenput, Liesbeth4 aut |
| 700 | 1 | a Waite, Lindsay L.4 aut |
| 700 | 1 | a Zhao, Jing Hua4 aut |
| 700 | 1 | a Absher, Devin4 aut |
| 700 | 1 | a Asselbergs, Folkert W.4 aut |
| 700 | 1 | a Atalay, Mustafa4 aut |
| 700 | 1 | a Attwood, Antony P.4 aut |
| 700 | 1 | a Balmforth, Anthony J.4 aut |
| 700 | 1 | a Basart, Hanneke4 aut |
| 700 | 1 | a Beilby, John4 aut |
| 700 | 1 | a Bonnycastle, Lori L.4 aut |
| 700 | 1 | a Brambilla, Paolo4 aut |
| 700 | 1 | a Bruinenberg, Marcel4 aut |
| 700 | 1 | a Campbell, Harry4 aut |
| 700 | 1 | a Chasman, Daniel I.4 aut |
| 700 | 1 | a Chines, Peter S.4 aut |
| 700 | 1 | a Collins, Francis S.4 aut0 375177 |
| 700 | 1 | a Connell, John M.4 aut |
| 700 | 1 | a Cookson, William O.4 aut |
| 700 | 1 | a de Faire, Ulf4 aut |
| 700 | 1 | a de Vegt, Femmie4 aut |
| 700 | 1 | a Dei, Mariano4 aut |
| 700 | 1 | a Dimitriou, Maria4 aut |
| 700 | 1 | a Edkins, Sarah4 aut |
| 700 | 1 | a Estrada, Karol4 aut |
| 700 | 1 | a Evans, David M.4 aut |
| 700 | 1 | a Farrall, Martin4 aut |
| 700 | 1 | a Ferrario, Marco M.4 aut |
| 700 | 1 | a Ferrieres, Jean4 aut |
| 700 | 1 | a Franke, Lude4 aut |
| 700 | 1 | a Frau, Francesca4 aut |
| 700 | 1 | a Gejman, Pablo V.4 aut |
| 700 | 1 | a Grallert, Harald4 aut |
| 700 | 1 | a Groenberg, Henrik4 aut |
| 700 | 1 | a Gudnason, Vilmundur4 aut |
| 700 | 1 | a Hall, Alistair S.4 aut |
| 700 | 1 | a Hall, Per4 aut |
| 700 | 1 | a Hartikainen, Anna-Liisa4 aut |
| 700 | 1 | a Hayward, Caroline4 aut |
| 700 | 1 | a Heard-Costa, Nancy L.4 aut |
| 700 | 1 | a Heath, Andrew C.4 aut |
| 700 | 1 | a Hebebrand, Johannes4 aut |
| 700 | 1 | a Homuth, Georg4 aut |
| 700 | 1 | a Hu, Frank B.4 aut |
| 700 | 1 | a Hunt, Sarah E.4 aut |
| 700 | 1 | a Hyppoenen, Elina4 aut |
| 700 | 1 | a Iribarren, Carlos4 aut |
| 700 | 1 | a Jacobs, Kevin B.4 aut |
| 700 | 1 | a Jansson, John-Olov4 aut |
| 700 | 1 | a Jula, Antti4 aut |
| 700 | 1 | a Kahonen, Mika4 aut |
| 700 | 1 | a Kathiresan, Sekar4 aut |
| 700 | 1 | a Kee, Frank4 aut |
| 700 | 1 | a Khaw, Kay-Tee4 aut |
| 700 | 1 | a Kivimaki, Mika4 aut |
| 700 | 1 | a Koenig, Wolfgang4 aut |
| 700 | 1 | a Kraja, Aldi T.4 aut |
| 700 | 1 | a Kumari, Meena4 aut |
| 700 | 1 | a Kuulasmaa, Kari4 aut |
| 700 | 1 | a Kuusisto, Johanna4 aut |
| 700 | 1 | a Laitinen, Jaana H.4 aut |
| 700 | 1 | a Lakka, Timo A.4 aut |
| 700 | 1 | a Langenberg, Claudia4 aut |
| 700 | 1 | a Launer, Lenore J.4 aut |
| 700 | 1 | a Lind, Lars4 aut |
| 700 | 1 | a Lindstrom, Jaana4 aut |
| 700 | 1 | a Liu, Jianjun4 aut |
| 700 | 1 | a Liuzzi, Antonio4 aut |
| 700 | 1 | a Lokki, Marja-Liisa4 aut |
| 700 | 1 | a Lorentzon, Mattias4 aut |
| 700 | 1 | a Madden, Pamela A.4 aut |
| 700 | 1 | a Magnusson, Patrik K.4 aut |
| 700 | 1 | a Manunta, Paolo4 aut |
| 700 | 1 | a Marek, Diana4 aut |
| 700 | 1 | a Maerz, Winfried4 aut |
| 700 | 1 | a Leach, Irene Mateo4 aut |
| 700 | 1 | a McKnight, Barbara4 aut |
| 700 | 1 | a Medland, Sarah E.4 aut |
| 700 | 1 | a Mihailov, Evelin4 aut |
| 700 | 1 | a Milani, Lili4 aut |
| 700 | 1 | a Montgomery, Grant W.4 aut |
| 700 | 1 | a Mooser, Vincent4 aut |
| 700 | 1 | a Muehleisen, Thomas W.4 aut |
| 700 | 1 | a Munroe, Patricia B.4 aut |
| 700 | 1 | a Musk, Arthur W.4 aut |
| 700 | 1 | a Narisu, Narisu4 aut |
| 700 | 1 | a Navis, Gerjan4 aut |
| 700 | 1 | a Nicholson, George4 aut |
| 700 | 1 | a Nohr, Ellen A.4 aut |
| 700 | 1 | a Ong, Ken K.4 aut |
| 700 | 1 | a Oostra, Ben A.4 aut |
| 700 | 1 | a Palmer, Colin N. A.4 aut |
| 700 | 1 | a Palotie, Aarno4 aut |
| 700 | 1 | a Peden, John F.4 aut |
| 700 | 1 | a Pedersen, Nancy4 aut |
| 700 | 1 | a Peters, Annette4 aut |
| 700 | 1 | a Polasek, Ozren4 aut |
| 700 | 1 | a Pouta, Anneli4 aut |
| 700 | 1 | a Pramstaller, Peter P.4 aut |
| 700 | 1 | a Prokopenko, Inga4 aut |
| 700 | 1 | a Puetter, Carolin4 aut |
| 700 | 1 | a Radhakrishnan, Aparna4 aut |
| 700 | 1 | a Raitakari, Olli4 aut |
| 700 | 1 | a Rendon, Augusto4 aut |
| 700 | 1 | a Rivadeneira, Fernando4 aut |
| 700 | 1 | a Rudan, Igor4 aut |
| 700 | 1 | a Saaristo, Timo E.4 aut |
| 700 | 1 | a Sambrook, Jennifer G.4 aut |
| 700 | 1 | a Sanders, Alan R.4 aut |
| 700 | 1 | a Sanna, Serena4 aut |
| 700 | 1 | a Saramies, Jouko4 aut |
| 700 | 1 | a Schipf, Sabine4 aut |
| 700 | 1 | a Schreiber, Stefan4 aut |
| 700 | 1 | a Schunkert, Heribert4 aut |
| 700 | 1 | a Shin, So-Youn4 aut |
| 700 | 1 | a Signorini, Stefano4 aut |
| 700 | 1 | a Sinisalo, Juha4 aut |
| 700 | 1 | a Skrobek, Boris4 aut |
| 700 | 1 | a Soranzo, Nicole4 aut |
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| 700 | 1 | a Stark, Klaus4 aut |
| 700 | 1 | a Stephens, Jonathan C.4 aut |
| 700 | 1 | a Stirrups, Kathleen4 aut |
| 700 | 1 | a Stolk, Ronald P.4 aut |
| 700 | 1 | a Stumvoll, Michael4 aut |
| 700 | 1 | a Swift, Amy J.4 aut |
| 700 | 1 | a Theodoraki, Eirini V.4 aut |
| 700 | 1 | a Thorand, Barbara4 aut |
| 700 | 1 | a Tregouet, David-Alexandre4 aut |
| 700 | 1 | a Tremoli, Elena4 aut |
| 700 | 1 | a Van der Klauw, Melanie M.4 aut |
| 700 | 1 | a van Meurs, Joyce B. J.4 aut |
| 700 | 1 | a Vermeulen, Sita H.4 aut |
| 700 | 1 | a Viikari, Jorma4 aut |
| 700 | 1 | a Virtamo, Jarmo4 aut |
| 700 | 1 | a Vitart, Veronique4 aut |
| 700 | 1 | a Waeber, Gerard4 aut |
| 700 | 1 | a Wang, Zhaoming4 aut |
| 700 | 1 | a Widen, Elisabeth4 aut |
| 700 | 1 | a Wild, Sarah H.4 aut |
| 700 | 1 | a Willemsen, Gonneke4 aut |
| 700 | 1 | a Winkelmann, Bernhard R.4 aut |
| 700 | 1 | a Witteman, Jacqueline C. M.4 aut |
| 700 | 1 | a Wolffenbuttel, Bruce H. R.4 aut |
| 700 | 1 | a Wong, Andrew4 aut |
| 700 | 1 | a Wright, Alan F.4 aut |
| 700 | 1 | a Zillikens, M. Carola4 aut |
| 700 | 1 | a Amouyel, Philippe4 aut |
| 700 | 1 | a Boehm, Bernhard O.4 aut |
| 700 | 1 | a Boerwinkle, Eric4 aut |
| 700 | 1 | a Boomsma, Dorret I.4 aut |
| 700 | 1 | a Caulfield, Mark J.4 aut |
| 700 | 1 | a Chanock, Stephen J.4 aut |
| 700 | 1 | a Cupples, L. Adrienne4 aut |
| 700 | 1 | a Cusi, Daniele4 aut |
| 700 | 1 | a Dedoussis, George V.4 aut |
| 700 | 1 | a Erdmann, Jeanette4 aut |
| 700 | 1 | a Eriksson, Johan G.4 aut |
| 700 | 1 | a Franks, Paul W.4 aut |
| 700 | 1 | a Froguel, Philippe4 aut |
| 700 | 1 | a Gieger, Christian4 aut |
| 700 | 1 | a Gyllensten, Ulf4 aut |
| 700 | 1 | a Hamsten, Anders4 aut |
| 700 | 1 | a Harris, Tamara B.4 aut |
| 700 | 1 | a Hengstenberg, Christian4 aut |
| 700 | 1 | a Hicks, Andrew A.4 aut |
| 700 | 1 | a Hingorani, Aroon4 aut |
| 700 | 1 | a Hinney, Anke4 aut |
| 700 | 1 | a Hofman, Albert4 aut |
| 700 | 1 | a Hovingh, Kees G.4 aut |
| 700 | 1 | a Hveem, Kristian4 aut |
| 700 | 1 | a Illig, Thomas4 aut |
| 700 | 1 | a Jarvelin, Marjo-Riitta4 aut |
| 700 | 1 | a Joeckel, Karl-Heinz4 aut |
| 700 | 1 | a Keinanen-Kiukaanniemi, Sirkka M.4 aut |
| 700 | 1 | a Kiemeney, Lambertus A.4 aut |
| 700 | 1 | a Kuh, Diana4 aut |
| 700 | 1 | a Laakso, Markku4 aut |
| 700 | 1 | a Lehtimaki, Terho4 aut |
| 700 | 1 | a Levinson, Douglas F.4 aut |
| 700 | 1 | a Martin, Nicholas G.4 aut |
| 700 | 1 | a Metspalu, Andres4 aut |
| 700 | 1 | a Morris, Andrew D.4 aut |
| 700 | 1 | a Nieminen, Markku S.4 aut |
| 700 | 1 | a Njolstad, Inger4 aut |
| 700 | 1 | a Ohlsson, Claes4 aut |
| 700 | 1 | a Oldehinkel, Albertine J.4 aut |
| 700 | 1 | a Ouwehand, Willem H.4 aut |
| 700 | 1 | a Palmer, Lyle J.4 aut |
| 700 | 1 | a Penninx, Brenda4 aut |
| 700 | 1 | a Power, Chris4 aut |
| 700 | 1 | a Province, Michael A.4 aut |
| 700 | 1 | a Psaty, Bruce M.4 aut |
| 700 | 1 | a Qi, Lu4 aut |
| 700 | 1 | a Rauramaa, Rainer4 aut |
| 700 | 1 | a Ridker, Paul M.4 aut |
| 700 | 1 | a Ripatti, Samuli4 aut |
| 700 | 1 | a Salomaa, Veikko4 aut |
| 700 | 1 | a Samani, Nilesh J.4 aut |
| 700 | 1 | a Snieder, Harold4 aut |
| 700 | 1 | a Sorensen, Thorkild I. A.4 aut |
| 700 | 1 | a Spector, Timothy D.4 aut |
| 700 | 1 | a Stefansson, Kari4 aut |
| 700 | 1 | a Tonjes, Anke4 aut |
| 700 | 1 | a Tuomilehto, Jaakko4 aut |
| 700 | 1 | a Uitterlinden, Andre G.4 aut |
| 700 | 1 | a Uusitupa, Matti4 aut |
| 700 | 1 | a van der Harst, Pim4 aut |
| 700 | 1 | a Vollenweider, Peter4 aut |
| 700 | 1 | a Wallaschofski, Henri4 aut |
| 700 | 1 | a Wareham, Nicholas J.4 aut |
| 700 | 1 | a Watkins, Hugh4 aut |
| 700 | 1 | a Wichmann, H-Erich4 aut |
| 700 | 1 | a Wilson, James F.4 aut |
| 700 | 1 | a Abecasis, Goncalo R.4 aut |
| 700 | 1 | a Assimes, Themistocles L.4 aut |
| 700 | 1 | a Barroso, Ines4 aut |
| 700 | 1 | a Boehnke, Michael4 aut |
| 700 | 1 | a Borecki, Ingrid B.4 aut |
| 700 | 1 | a Deloukas, Panos4 aut |
| 700 | 1 | a Fox, Caroline S.4 aut |
| 700 | 1 | a Frayling, Timothy4 aut |
| 700 | 1 | a Groop, Leif C.4 aut |
| 700 | 1 | a Haritunian, Talin4 aut |
| 700 | 1 | a Heid, Iris M.4 aut |
| 700 | 1 | a Hunter, David4 aut |
| 700 | 1 | a Kaplan, Robert C.4 aut |
| 700 | 1 | a Karpe, Fredrik4 aut |
| 700 | 1 | a Moffatt, Miriam F.4 aut |
| 700 | 1 | a Mohlke, Karen L.4 aut |
| 700 | 1 | a O'Connell, Jeffrey R.4 aut |
| 700 | 1 | a Pawitan, Yudi4 aut |
| 700 | 1 | a Schadt, Eric E.4 aut |
| 700 | 1 | a Schlessinger, David4 aut |
| 700 | 1 | a Steinthorsdottir, Valgerdur4 aut |
| 700 | 1 | a Strachan, David P.4 aut |
| 700 | 1 | a Thorsteinsdottir, Unnur4 aut |
| 700 | 1 | a van Duijn, Cornelia M.4 aut |
| 700 | 1 | a Visscher, Peter M.4 aut |
| 700 | 1 | a Di Blasio, Anna Maria4 aut |
| 700 | 1 | a Hirschhorn, Joel N.4 aut |
| 700 | 1 | a Lindgren, Cecilia M.4 aut |
| 700 | 1 | a Morris, Andrew P.4 aut |
| 700 | 1 | a Meyre, David4 aut |
| 700 | 1 | a Scherag, Andr4 aut |
| 700 | 1 | a McCarthy, Mark I.4 aut |
| 700 | 1 | a Speliotes, Elizabeth K.4 aut |
| 700 | 1 | a North, Kari E.4 aut |
| 700 | 1 | a Loos, Ruth J. F.4 aut |
| 700 | 1 | a Ingelsson, Erik4 aut |
| 710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
| 710 | 1 2 | a Uppsala universitetb Science for Life Laboratory, SciLifeLab4 pbl |
| 710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
| 710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
| 710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
| 772 | 1 8 | i channel recordw 19753896 |
| 773 | 0 8 | i Värdpublikationt Nature Geneticsg 45:5, 501-U69x 1061-4036 |
| 856 | 4 0 | u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-200675 |
| 856 | 4 0 | u http://dx.doi.org/10.1038/ng.2606 |
| 856 | 4 0 | u http://uu.diva-portal.org/smash/get/diva2:624801/FULLTEXT02 |
| 900 | 1 s | 6 700a Collins, Francis Sellarsu Collins, Francis S. |
| 900 | 1 s | 6 700a Collins, Francis,d 1950-u Collins, Francis S. |
| 841 | 5 APISa x ab 171207||0000|||||001||||||000000e 1 | |
| 024 | 7 | 5 APISa urn:nbn:se:uu:diva-2006752 urn |
| 852 | 5 APISb APIS | |
| 856 | 4 0 | 5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-200675 |
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