Sökning: WFRF:(Alves Alexessander Couto) > Association of vita...
Fältnamn | Indikatorer | Metadata |
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000 | 08716naa a22017293a 4500 | |
001 | 22068493 | |
003 | SE-LIBR | |
005 | 20171206155755.0 | |
007 | cr|||||||||||| | |
008 | 171206s2014 sw |||| o |||| ||eng c | |
024 | 7 | a http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2332642 uri |
024 | 7 | a urn:nbn:se:uu:diva-2332642 urn |
024 | 7 | a 10.1016/S2213-8587(14)70113-52 doi |
040 | a S | |
041 | 0 | a eng |
042 | 9 EPLK | |
100 | 1 | a Vimaleswaran, Karani S4 aut |
245 | 1 0 | a Association of vitamin D status with arterial blood pressure and hypertension riskh [Elektronisk resurs]b a mendelian randomisation study |
260 | c 2014 | |
500 | a Published | |
506 | 0 | a gratis |
520 | a BACKGROUND: Low plasma 25-hydroxyvitamin D (25[OH]D) concentration is associated with high arterial blood pressure and hypertension risk, but whether this association is causal is unknown. We used a mendelian randomisation approach to test whether 25(OH)D concentration is causally associated with blood pressure and hypertension risk. METHODS: In this mendelian randomisation study, we generated an allele score (25[OH]D synthesis score) based on variants of genes that affect 25(OH)D synthesis or substrate availability (CYP2R1 and DHCR7), which we used as a proxy for 25(OH)D concentration. We meta-analysed data for up to 108 173 individuals from 35 studies in the D-CarDia collaboration to investigate associations between the allele score and blood pressure measurements. We complemented these analyses with previously published summary statistics from the International Consortium on Blood Pressure (ICBP), the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, and the Global Blood Pressure Genetics (Global BPGen) consortium. FINDINGS: In phenotypic analyses (up to n=49 363), increased 25(OH)D concentration was associated with decreased systolic blood pressure (β per 10% increase, -0·12 mm Hg, 95% CI -0·20 to -0·04; p=0·003) and reduced odds of hypertension (odds ratio [OR] 0·98, 95% CI 0·97-0·99; p=0·0003), but not with decreased diastolic blood pressure (β per 10% increase, -0·02 mm Hg, -0·08 to 0·03; p=0·37). In meta-analyses in which we combined data from D-CarDia and the ICBP (n=146 581, after exclusion of overlapping studies), each 25(OH)D-increasing allele of the synthesis score was associated with a change of -0·10 mm Hg in systolic blood pressure (-0·21 to -0·0001; p=0·0498) and a change of -0·08 mm Hg in diastolic blood pressure (-0·15 to -0·02; p=0·01). When D-CarDia and consortia data for hypertension were meta-analysed together (n=142 255), the synthesis score was associated with a reduced odds of hypertension (OR per allele, 0·98, 0·96-0·99; p=0·001). In instrumental variable analysis, each 10% increase in genetically instrumented 25(OH)D concentration was associated with a change of -0·29 mm Hg in diastolic blood pressure (-0·52 to -0·07; p=0·01), a change of -0·37 mm Hg in systolic blood pressure (-0·73 to 0·003; p=0·052), and an 8·1% decreased odds of hypertension (OR 0·92, 0·87-0·97; p=0·002). INTERPRETATION: Increased plasma concentrations of 25(OH)D might reduce the risk of hypertension. This finding warrants further investigation in an independent, similarly powered study. | |
650 | 7 | a Medical and Health Sciences2 hsv |
650 | 7 | a Clinical Medicine2 hsv |
650 | 7 | a Endocrinology and Diabetes2 hsv |
650 | 7 | a Medicin och hälsovetenskap2 hsv |
650 | 7 | a Klinisk medicin2 hsv |
650 | 7 | a Endokrinologi och diabetes2 hsv |
700 | 1 | a Cavadino, Alana4 aut |
700 | 1 | a Berry, Diane J4 aut |
700 | 1 | a Jorde, Rolf4 aut |
700 | 1 | a Dieffenbach, Aida Karina4 aut |
700 | 1 | a Lu, Chen4 aut |
700 | 1 | a Alves, Alexessander Couto4 aut |
700 | 1 | a Heerspink, Hiddo J Lambers4 aut |
700 | 1 | a Tikkanen, Emmi4 aut |
700 | 1 | a Eriksson, Joel4 aut |
700 | 1 | a Wong, Andrew4 aut |
700 | 1 | a Mangino, Massimo4 aut |
700 | 1 | a Jablonski, Kathleen A4 aut |
700 | 1 | a Nolte, Ilja M4 aut |
700 | 1 | a Houston, Denise K4 aut |
700 | 1 | a Ahluwalia, Tarunveer Singh4 aut |
700 | 1 | a van der Most, Peter J4 aut |
700 | 1 | a Pasko, Dorota4 aut |
700 | 1 | a Zgaga, Lina4 aut |
700 | 1 | a Thiering, Elisabeth4 aut |
700 | 1 | a Vitart, Veronique4 aut |
700 | 1 | a Fraser, Ross M4 aut |
700 | 1 | a Huffman, Jennifer E4 aut |
700 | 1 | a de Boer, Rudolf A4 aut |
700 | 1 | a Schöttker, Ben4 aut |
700 | 1 | a Saum, Kai-Uwe4 aut |
700 | 1 | a McCarthy, Mark I4 aut |
700 | 1 | a Dupuis, Josée4 aut |
700 | 1 | a Herzig, Karl-Heinz4 aut |
700 | 1 | a Sebert, Sylvain4 aut |
700 | 1 | a Pouta, Anneli4 aut |
700 | 1 | a Laitinen, Jaana4 aut |
700 | 1 | a Kleber, Marcus E4 aut |
700 | 1 | a Navis, Gerjan4 aut |
700 | 1 | a Lorentzon, Mattias4 aut |
700 | 1 | a Jameson, Karen4 aut |
700 | 1 | a Arden, Nigel4 aut |
700 | 1 | a Cooper, Jackie A4 aut |
700 | 1 | a Acharya, Jayshree4 aut |
700 | 1 | a Hardy, Rebecca4 aut |
700 | 1 | a Raitakari, Olli4 aut |
700 | 1 | a Ripatti, Samuli4 aut |
700 | 1 | a Billings, Liana K4 aut |
700 | 1 | a Lahti, Jari4 aut |
700 | 1 | a Osmond, Clive4 aut |
700 | 1 | a Penninx, Brenda W4 aut |
700 | 1 | a Rejnmark, Lars4 aut |
700 | 1 | a Lohman, Kurt K4 aut |
700 | 1 | a Paternoster, Lavinia4 aut |
700 | 1 | a Stolk, Ronald P4 aut |
700 | 1 | a Hernandez, Dena G4 aut |
700 | 1 | a Byberg, Liisa4 aut |
700 | 1 | a Hagström, Emil4 aut |
700 | 1 | a Melhus, Håkan4 aut |
700 | 1 | a Ingelsson, Erik4 aut |
700 | 1 | a Mellström, Dan4 aut |
700 | 1 | a Ljunggren, Östen4 aut |
700 | 1 | a Tzoulaki, Ioanna4 aut |
700 | 1 | a McLachlan, Stela4 aut |
700 | 1 | a Theodoratou, Evropi4 aut |
700 | 1 | a Tiesler, Carla M T4 aut |
700 | 1 | a Jula, Antti4 aut |
700 | 1 | a Navarro, Pau4 aut |
700 | 1 | a Wright, Alan F4 aut |
700 | 1 | a Polasek, Ozren4 aut |
700 | 1 | a Wilson, James F4 aut |
700 | 1 | a Rudan, Igor4 aut |
700 | 1 | a Salomaa, Veikko4 aut |
700 | 1 | a Heinrich, Joachim4 aut |
700 | 1 | a Campbell, Harry4 aut |
700 | 1 | a Price, Jacqueline F4 aut |
700 | 1 | a Karlsson, Magnus4 aut |
700 | 1 | a Lind, Lars4 aut |
700 | 1 | a Michaëlsson, Karl4 aut |
700 | 1 | a Bandinelli, Stefania4 aut |
700 | 1 | a Frayling, Timothy M4 aut |
700 | 1 | a Hartman, Catharina A4 aut |
700 | 1 | a Sørensen, Thorkild I A4 aut |
700 | 1 | a Kritchevsky, Stephen B4 aut |
700 | 1 | a Langdahl, Bente Lomholt4 aut |
700 | 1 | a Eriksson, Johan G4 aut |
700 | 1 | a Florez, Jose C4 aut |
700 | 1 | a Spector, Tim D4 aut |
700 | 1 | a Lehtimäki, Terho4 aut |
700 | 1 | a Kuh, Diana4 aut |
700 | 1 | a Humphries, Steve E4 aut |
700 | 1 | a Cooper, Cyrus4 aut |
700 | 1 | a Ohlsson, Claes4 aut |
700 | 1 | a März, Winfried4 aut |
700 | 1 | a de Borst, Martin H4 aut |
700 | 1 | a Kumari, Meena4 aut |
700 | 1 | a Kivimaki, Mika4 aut |
700 | 1 | a Wang, Thomas J4 aut |
700 | 1 | a Power, Chris4 aut |
700 | 1 | a Brenner, Hermann4 aut |
700 | 1 | a Grimnes, Guri4 aut |
700 | 1 | a van der Harst, Pim4 aut |
700 | 1 | a Snieder, Harold4 aut |
700 | 1 | a Hingorani, Aroon D4 aut |
700 | 1 | a Pilz, Stefan4 aut |
700 | 1 | a Whittaker, John C4 aut |
700 | 1 | a Järvelin, Marjo-Riitta4 aut |
700 | 1 | a Hyppönen, Elina4 aut |
710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
710 | 1 2 | a Uppsala universitetb Science for Life Laboratory, SciLifeLab4 pbl |
710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
772 | 1 8 | i channel recordw 19753896 |
773 | 0 8 | i Värdpublikationt The Lancet Diabetes and Endocrinologyg 2:9, 719-729x 2213-8587 |
856 | 4 0 | u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-233264 |
856 | 4 0 | u http://dx.doi.org/10.1016/S2213-8587(14)70113-5 |
856 | 4 0 | u http://uu.diva-portal.org/smash/get/diva2:751534/FULLTEXT01 |
841 | 5 APISa x ab 171206||0000|||||001||||||000000e 1 | |
024 | 7 | 5 APISa urn:nbn:se:uu:diva-2332642 urn |
852 | 5 APISb APIS | |
856 | 4 0 | 5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-233264 |
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