WFRF:(Kivipelto Miia 1973 )
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Risk factors for incident dementia in the very old
- Wallin, Karin (författare)
- Boström, Gustaf (författare)
- Kivipelto, Miia, 1973- (författare)
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- Gustafson, Yngve (författare)
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- (utgivare)
- 2013
- 2013
- Engelska.
- Ingår i: International psychogeriatrics. - 1041-6102. ; 25:7, 1135-1143
- swepub:Mat__t
Abstract
Ämnesord
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- Background : Several risk factors for dementia, Alzheimer's disease, and cognitive impairment have been established; however, knowledge about risk factors in the very old population (>= 85 years) is limited. This study describes the association of several baseline factors with dementia in participants aged >= 85 years, and investigates factors associated with a higher risk of incident dementia over five years. Methods : The participants in this population-based cohort study were aged 85, 90, and >= 95 years at baseline (2000-2002). Data were collected during home visits for interviews and testing, from a review of medical records, and/or interviewing the caregiver or next of kin. After five years 212 participants could be followed up concerning incident dementia. Multivariate logistic regression was used. Results : At baseline, 100/353 (28%) of participants had a dementia diagnosis. Over five years, 71/212 (33.5%) participants developed dementia. Few participants with dementia at baseline remained alive after five years (12%). Depression at the baseline and follow-up time were associated with a higher risk of dementia, odds ratio (OR) (95% CI, p-value) 2.91 (1.37-6.16, 0.005) and 1.61 (1.26-2.05, <0.001) respectively. More social contact and a higher Mini-Mental State Examination score at baseline were associated with lower risk of incident dementia, OR (95% CI, p-value) 0.87 (0.78-0.97, 0.009) and 0.83 (0.74-0.93, 0.001) respectively. Conclusions : Prevalence and incidence of dementia are high in very old people and dementia appears to be a fatal disorder. Depression is associated with higher risk of incident dementia over five years whereas more frequent social contacts and a higher MMSE score are associated with lower risk.
Ämnesord
- Medical and Health Sciences (ssif)
- Clinical Medicine (ssif)
- Geriatrics (ssif)
- Medicin och hälsovetenskap (ssif)
- Klinisk medicin (ssif)
- Geriatrik (ssif)
Genre
- government publication (marcgt)
Nyckelord
- aged
- 80 and over
- longitudinal
- population-based
- depression
- social isolation
- prevalence
- incidence
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