Genetic loci associated with heart rate variability and their effects on cardiac disease risk

doi:10.1038/ncomms15805

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MARC

Fältnamn	Indikatorer	Metadata
000		09060naa a22023653a 4500
001		21571495
003		SE-LIBR
005		20170920154648.0
007		cr\|\|\|\|\|\|\|\|\|\|\|\|
008		170920s2017 sw \|\|\|\| o \|\|\|\| \|\|eng c
024	7	a http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3296722 uri
024	7	a urn:nbn:se:uu:diva-3296722 urn
024	7	a 10.1038/ncomms158052 doi
040		a S
041	0	a eng
042		9 EPLK
100	1	a Nolte, Ilja M.4 aut
245	1 0	a Genetic loci associated with heart rate variability and their effects on cardiac disease riskh [Elektronisk resurs]
260		b NATURE PUBLISHING GROUPc 2017
500		a Published
506	0	a gratis
520		a Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide association studies for three HRV traits in up to 53,174 individuals of European ancestry, we detect 17 genome-wide significant SNPs in eight loci. HRV SNPs tag non-synonymous SNPs (in NDUFA11 and KIAA1755), expression quantitative trait loci (eQTLs) (influencing GNG11, RGS6 and NEO1), or are located in genes preferentially expressed in the sinoatrial node (GNG11, RGS6 and HCN4). Genetic risk scores account for 0.9 to 2.6% of the HRV variance. Significant genetic correlation is found for HRV with heart rate (-0.74 < r(g) < -0.55) and blood pressure (-0.35 < r(g) < -0.20). These findings provide clinically relevant biological insight into heritable variation in vagal heart rhythm regulation, with a key role for genetic variants (GNG11, RGS6) that influence G-protein heterotrimer action in GIRK-channel induced pacemaker membrane hyperpolarization.
650	7	a Medical and Health Sciences2 hsv
650	7	a Medicin och hälsovetenskap2 hsv
700	1	a Munoz, M. Loretto4 aut
700	1	a Tragante, Vinicius4 aut
700	1	a Amare, Azmeraw T.4 aut
700	1	a Jansen, Rick4 aut
700	1	a Vaez, Ahmad4 aut
700	1	a von der Heyde, Benedikt4 aut
700	1	a Avery, Christy L.4 aut
700	1	a Bis, Joshua C.4 aut
700	1	a Dierckx, Bram4 aut
700	1	a van Dongen, Jenny4 aut
700	1	a Gogarten, Stephanie M.4 aut
700	1	a Goyette, Philippe4 aut
700	1	a Hernesniemi, Jussi4 aut
700	1	a Huikari, Ville4 aut
700	1	a Hwang, Shih-Jen4 aut
700	1	a Jaju, Deepali4 aut
700	1	a Kerr, Kathleen F.4 aut
700	1	a Kluttig, Alexander4 aut
700	1	a Krijthe, Bouwe P.4 aut
700	1	a Kumar, Jitender4 aut
700	1	a van der Laan, Sander W.4 aut
700	1	a Lyytikainen, Leo-Pekka4 aut
700	1	a Maihofer, Adam X.4 aut
700	1	a Minassian, Arpi4 aut
700	1	a van der Most, Peter J.4 aut
700	1	a Mueller-Nurasyid, Martina4 aut
700	1	a Nivard, Michel4 aut
700	1	a Salvi, Erika4 aut
700	1	a Stewart, James D.4 aut
700	1	a Thayer, Julian F.4 aut
700	1	a Verweij, Niek4 aut
700	1	a Wong, Andrew4 aut
700	1	a Zabaneh, Delilah4 aut
700	1	a Zafarmand, Mohammad H.4 aut
700	1	a Abdellaoui, Abdel4 aut
700	1	a Albarwani, Sulayma4 aut
700	1	a Albert, Christine4 aut
700	1	a Alonso, Alvaro4 aut
700	1	a Ashar, Foram4 aut
700	1	a Auvinen, Juha4 aut
700	1	a Axelsson, Tomas4 aut
700	1	a Baker, Dewleen G.4 aut
700	1	a de Bakker, Paul I. W.4 aut
700	1	a Barcella, Matteo4 aut
700	1	a Bayoumi, Riad4 aut
700	1	a Bieringa, Rob J.4 aut
700	1	a Boomsma, Dorret4 aut
700	1	a Boucher, Gabrielle4 aut
700	1	a Britton, Annie R.4 aut
700	1	a Christophersen, Ingrid E.4 aut
700	1	a Dietrich, Andrea4 aut
700	1	a Ehret, George B.4 aut
700	1	a Ellinor, Patrick T.4 aut
700	1	a Eskola, Markku4 aut
700	1	a Felix, Janine F.4 aut
700	1	a Floras, John S.4 aut
700	1	a Franco, Oscar H.4 aut
700	1	a Friberg, Peter4 aut
700	1	a Gademan, Maaike G. J.4 aut
700	1	a Geyer, Mark A.4 aut
700	1	a Giedraitis, Vilmantas4 aut
700	1	a Hartman, Catharina A.4 aut
700	1	a Hemerich, Daiane4 aut
700	1	a Hofman, Albert4 aut
700	1	a Hottenga, Jouke-Jan4 aut
700	1	a Huikuri, Heikki4 aut
700	1	a Hutri-Kahonen, Nina4 aut
700	1	a Jouven, Xavier4 aut
700	1	a Junttila, Juhani4 aut
700	1	a Juonala, Markus4 aut
700	1	a Kiviniemi, Antti M.4 aut
700	1	a Kors, Jan A.4 aut
700	1	a Kumari, Meena4 aut
700	1	a Kuznetsova, Tatiana4 aut
700	1	a Laurie, Cathy C.4 aut
700	1	a Lefrandt, Joop D.4 aut
700	1	a Li, Yong4 aut
700	1	a Li, Yun4 aut
700	1	a Liao, Duanping4 aut
700	1	a Limacher, Marian C.4 aut
700	1	a Lin, Henry J.4 aut
700	1	a Lindgren, Cecilia M.4 aut
700	1	a Lubitz, Steven A.4 aut
700	1	a Mahajan, Anubha4 aut
700	1	a McKnight, Barbara4 aut
700	1	a zu Schwabedissen, Henriette Meyer4 aut
700	1	a Milaneschi, Yuri4 aut
700	1	a Mononen, Nina4 aut
700	1	a Morris, Andrew P.4 aut
700	1	a Nalls, Mike A.4 aut
700	1	a Navis, Gerjan4 aut
700	1	a Neijts, Melanie4 aut
700	1	a Nikus, Kjell4 aut
700	1	a North, Kari E.4 aut
700	1	a O'Connor, Daniel T.4 aut
700	1	a Ormel, Johan4 aut
700	1	a Perz, Siegfried4 aut
700	1	a Peters, Annette4 aut
700	1	a Psaty, Bruce M.4 aut
700	1	a Raitakari, Olli T.4 aut
700	1	a Risbrough, Victoria B.4 aut
700	1	a Sinner, Moritz F.4 aut
700	1	a Siscovick, David4 aut
700	1	a Smit, Johannes H.4 aut
700	1	a Smith, Nicholas L.4 aut
700	1	a Soliman, Elsayed Z.4 aut
700	1	a Sotoodehnia, Nona4 aut
700	1	a Staessen, Jan A.4 aut
700	1	a Stein, Phyllis K.4 aut
700	1	a Stilp, Adrienne M.4 aut
700	1	a Stolarz-Skrzypek, Katarzyna4 aut
700	1	a Strauch, Konstantin4 aut
700	1	a Sundstrom, Johan4 aut
700	1	a Swenne, Cees A.4 aut
700	1	a Syvänen, Ann-Christined 1950-4 aut
700	1	a Tardif, Jean-Claude4 aut
700	1	a Taylor, Kent D.4 aut
700	1	a Teumer, Alexander4 aut
700	1	a Thornton, Timothy A.4 aut
700	1	a Tinker, Lesley E.4 aut
700	1	a Uitterlinden, Andre G.4 aut
700	1	a van Setten, Jessica4 aut
700	1	a Voss, Andreas4 aut
700	1	a Waldenberger, Melanie4 aut
700	1	a Wilhelmsen, Kirk C.4 aut
700	1	a Willemsen, Gonneke4 aut
700	1	a Wong, Quenna4 aut
700	1	a Zhang, Zhu-Ming4 aut
700	1	a Zonderman, Alan B.4 aut
700	1	a Cusi, Daniele4 aut
700	1	a Evans, Michele K.4 aut
700	1	a Greiser, Halina K.4 aut
700	1	a van der Harst, Pim4 aut
700	1	a Hassan, Mohammad4 aut
700	1	a Ingelsson, Erikd 1975-4 aut0 264196
700	1	a Jarvelin, Marjo-Riitta4 aut
700	1	a Kaab, Stefan4 aut
700	1	a Kahonen, Mika4 aut
700	1	a Kivimaki, Mika4 aut
700	1	a Kooperberg, Charles4 aut
700	1	a Kuh, Diana4 aut
700	1	a Lehtimaki, Terho4 aut
700	1	a Lind, Lars4 aut
700	1	a Nievergelt, Caroline M.4 aut
700	1	a O'Donnell, Chris J.4 aut
700	1	a Oldehinkel, Albertine J.4 aut
700	1	a Penninx, Brenda4 aut
700	1	a Reiner, Alexander P.4 aut
700	1	a Riese, Harriette4 aut
700	1	a van Roon, Arie M.4 aut
700	1	a Rioux, John D.4 aut
700	1	a Rotter, Jerome I.4 aut
700	1	a Sofer, Tamar4 aut
700	1	a Stricker, Bruno H.4 aut
700	1	a Tiemeier, Henning4 aut
700	1	a Vrijkotte, Tanja G. M.4 aut
700	1	a Asselbergs, Folkert W.4 aut
700	1	a Brundel, Bianca J. J. M.4 aut
700	1	a Heckbert, Susan R.4 aut
700	1	a Whitsel, Eric A.4 aut
700	1	a den Hoed, Marcel4 aut
700	1	a Snieder, Harold4 aut
700	1	a de Geus, Eco J. C.4 aut
710	1 2	a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl
710	1 2	a Uppsala universitetb Science for Life Laboratory, SciLifeLab4 pbl
710	1 2	a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl
710	1 2	a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl
772	1 8	i channel recordw 19753896
773	0 8	i Värdpublikationt Nature Communicationsg 8x 2041-1723
856	4 0	u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-329672
856	4 0	u http://dx.doi.org/10.1038/ncomms15805
856	4 0	u http://uu.diva-portal.org/smash/get/diva2:1142582/FULLTEXT01
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024	7	5 APISa urn:nbn:se:uu:diva-3296722 urn
852		5 APISb APIS
856	4 0	5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-329672

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By the author/editor: Nolte, Ilja M.; Munoz, M. Lorett ...; Tragante, Vinici ...; Amare, Azmeraw T ...; Jansen, Rick; Vaez, Ahmad; show more...; von der Heyde, B ...; Avery, Christy L ...; Bis, Joshua C.; Dierckx, Bram; van Dongen, Jenn ...; Gogarten, Stepha ...; Goyette, Philipp ...; Hernesniemi, Jus ...; Huikari, Ville; Hwang, Shih-Jen; Jaju, Deepali; Kerr, Kathleen F ...; Kluttig, Alexand ...; Krijthe, Bouwe P ...; Kumar, Jitender; van der Laan, Sa ...; Lyytikainen, Leo ...; Maihofer, Adam X ...; Minassian, Arpi; van der Most, Pe ...; Mueller-Nurasyid ...; Nivard, Michel; Salvi, Erika; Stewart, James D ...; Thayer, Julian F ...; Verweij, Niek; Wong, Andrew; Zabaneh, Delilah; Zafarmand, Moham ...; Abdellaoui, Abde ...; Albarwani, Sulay ...; Albert, Christin ...; Alonso, Alvaro; Ashar, Foram; Auvinen, Juha; Axelsson, Tomas; Baker, Dewleen G ...; de Bakker, Paul ...; Barcella, Matteo; Bayoumi, Riad; Bieringa, Rob J.; Boomsma, Dorret; Boucher, Gabriel ...; Britton, Annie R ...; Christophersen, ...; Dietrich, Andrea; Ehret, George B.; Ellinor, Patrick ...; Eskola, Markku; Felix, Janine F.; Floras, John S.; Franco, Oscar H.; Friberg, Peter; Gademan, Maaike ...; Geyer, Mark A.; Giedraitis, Vilm ...; Hartman, Cathari ...; Hemerich, Daiane; Hofman, Albert; Hottenga, Jouke- ...; Huikuri, Heikki; Hutri-Kahonen, N ...; Jouven, Xavier; Junttila, Juhani; Juonala, Markus; Kiviniemi, Antti ...; Kors, Jan A.; Kumari, Meena; Kuznetsova, Tati ...; Laurie, Cathy C.; Lefrandt, Joop D ...; Li, Yong; Li, Yun; Liao, Duanping; Limacher, Marian ...; Lin, Henry J.; Lindgren, Cecili ...; Lubitz, Steven A ...; Mahajan, Anubha; McKnight, Barbar ...; zu Schwabedissen ...; Milaneschi, Yuri; Mononen, Nina; Morris, Andrew P ...; Nalls, Mike A.; Navis, Gerjan; Neijts, Melanie; Nikus, Kjell; North, Kari E.; O'Connor, Daniel ...; Ormel, Johan; Perz, Siegfried; Peters, Annette; Psaty, Bruce M.; Raitakari, Olli ...; Risbrough, Victo ...; Sinner, Moritz F ...; Siscovick, David; Smit, Johannes H ...; Smith, Nicholas ...; Soliman, Elsayed ...; Sotoodehnia, Non ...; Staessen, Jan A.; Stein, Phyllis K ...; Stilp, Adrienne ...; Stolarz-Skrzypek ...; Strauch, Konstan ...; Sundstrom, Johan; Swenne, Cees A.; Syvänen, Ann-Chr ...; Tardif, Jean-Cla ...; Taylor, Kent D.; Teumer, Alexande ...; Thornton, Timoth ...; Tinker, Lesley E ...; Uitterlinden, An ...; van Setten, Jess ...; Voss, Andreas; Waldenberger, Me ...; Wilhelmsen, Kirk ...; Willemsen, Gonne ...; Wong, Quenna; Zhang, Zhu-Ming; Zonderman, Alan ...; Cusi, Daniele; Evans, Michele K ...; Greiser, Halina ...; van der Harst, P ...; Hassan, Mohammad; Ingelsson, Erik ...; Jarvelin, Marjo- ...; Kaab, Stefan; Kahonen, Mika; Kivimaki, Mika; Kooperberg, Char ...; Kuh, Diana; Lehtimaki, Terho; Lind, Lars; Nievergelt, Caro ...; O'Donnell, Chris ...; Oldehinkel, Albe ...; Penninx, Brenda; Reiner, Alexande ...; Riese, Harriette; van Roon, Arie M ...; Rioux, John D.; Rotter, Jerome I ...; Sofer, Tamar; Stricker, Bruno ...; Tiemeier, Hennin ...; Vrijkotte, Tanja ...; Asselbergs, Folk ...; Brundel, Bianca ...; Heckbert, Susan ...; Whitsel, Eric A.; den Hoed, Marcel; Snieder, Harold; de Geus, Eco J. ...; show less...

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