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Genetic variants as...
Genetic variants associated with angiotensin-converting enzyme inhibitor-induced cough a genome-wide association study in a Swedish population
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Hallberg, Pär (författare)
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Persson, Matilda (författare)
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Axelsson, Tomas (författare)
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Cavalli, Marco (författare)
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Norling, Pia (författare)
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Johansson, Hans-Erik (författare)
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Yue, Qun-Ying (författare)
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Magnusson, Patrik K. E. (författare)
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Wadelius, Claes (författare)
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Eriksson, Niclas (författare)
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Wadelius, Mia (författare)
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- FUTURE MEDICINE LTD 2017
- 2017
- Engelska.
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Ingår i: Pharmacogenomics (London). - 1462-2416. ; 18:3, 201-213
Abstract
Ämnesord
Stäng
- Aim: We conducted a genome-wide association study on angiotensin-converting enzyme inhibitor-induced cough and used our dataset to replicate candidate genes iden-tified in previous studies. Patients & methods: A total of 124 patients and 1345 treated controls were genotyped using Illumina arrays. The genome-wide significance level was set to p < 5 x 10(-8). Results: We identified nearly genome-wide significant associations in CLASP1, PDE11A, KCNMB2, TGFA, SLC38A6 and MMP16. The strongest association was with rs62151109 in CLASP1 (odds ratio: 3.97; p = 9.44 x 10(-8)). All top hits except two were located in intronic or noncoding DNA regions. None of the candidate genes were significantly associated in our study. Conclusion: Angiotensin-converting enzyme inhibitor-induced cough is potentially associated with genes that are independent of bradykinin pathways.
Ämnesord
- Medical and Health Sciences (hsv)
- Basic Medicine (hsv)
- Pharmacology and Toxicology (hsv)
- Medicin och hälsovetenskap (hsv)
- Medicinska grundvetenskaper (hsv)
- Farmakologi och toxikologi (hsv)
Nyckelord
- angiotensin converting enzyme inhibitors
- bradykinin
- cough
- drug-related side effects and adverse reactions
- enalapril
- genome-wide association study
- lisinopril
- pharmacogenetics
- quinapril
- ramipril
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Till lärosätets databas
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Hallberg, Pär
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Persson, Matilda
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Axelsson, Tomas
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Cavalli, Marco
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Norling, Pia
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Johansson, Hans- ...
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visa fler...
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Yue, Qun-Ying
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Magnusson, Patri ...
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Wadelius, Claes
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Eriksson, Niclas
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Wadelius, Mia
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visa färre...
- Av lärosätet
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