Breast cancer risk and 6q22.33 combined results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2

doi:10.1371/journal.pone.0035706

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LIBRIS Formathandbok (Information om MARC21)

Fältnamn	Indikatorer	Metadata
000		08151naa a22020533a 4500
001		22098936
003		SE-LIBR
005		20171211073550.0
007		cr\|\|\|\|\|\|\|\|\|\|\|\|
008		171211s2012 sw \|\|\|\| o \|\|\|\| \|\|eng c
024	7	a http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-601442 uri
024	7	a urn:nbn:se:umu:diva-601442 urn
024	7	a 10.1371/journal.pone.00357062 doi
040		a S
041	0	a eng
042		9 EPLK
100	1	a Kirchhoff, Tomas4 aut
245	1 0	a Breast cancer risk and 6q22.33h [Elektronisk resurs]b combined results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2
260		b Public library of sciencec 2012
500		a Published
506	0	a gratis
520		a Recently, a locus on chromosome 6q22.33 (rs2180341) was reported to be associated with increased breast cancer risk in the Ashkenazi Jewish (AJ) population, and this association was also observed in populations of non-AJ European ancestry. In the present study, we performed a large replication analysis of rs2180341 using data from 31,428 invasive breast cancer cases and 34,700 controls collected from 25 studies in the Breast Cancer Association Consortium (BCAC). In addition, we evaluated whether rs2180341 modifies breast cancer risk in 3,361 BRCA1 and 2,020 BRCA2 carriers from 11 centers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Based on the BCAC data from women of European ancestry, we found evidence for a weak association with breast cancer risk for rs2180341 (per-allele odds ratio (OR) = 1.03, 95% CI 1.00-1.06, p = 0.023). There was evidence for heterogeneity in the ORs among studies (I(2) = 49.3%; p = <0.004). In CIMBA, we observed an inverse association with the minor allele of rs2180341 and breast cancer risk in BRCA1 mutation carriers (per-allele OR = 0.89, 95%CI 0.80-1.00, p = 0.048), indicating a potential protective effect of this allele. These data suggest that that 6q22.33 confers a weak effect on breast cancer risk.
650	7	a Medical and Health Sciences2 hsv
650	7	a Clinical Medicine2 hsv
650	7	a Cancer and Oncology2 hsv
650	7	a Medicin och hälsovetenskap2 hsv
650	7	a Klinisk medicin2 hsv
650	7	a Cancer och onkologi2 hsv
653	0	a genome-wide association
653	0	a susceptibility loci
653	0	a variants
653	0	a alleles
653	0	a FGFR2
653	0	a gene
700	1	a Gaudet, Mia M4 aut
700	1	a Antoniou, Antonis C4 aut
700	1	a McGuffog, Lesley4 aut
700	1	a Humphreys, Manjeet K4 aut
700	1	a Dunning, Alison M4 aut
700	1	a Bojesen, Stig E4 aut
700	1	a Nordestgaard, Børge G4 aut
700	1	a Flyger, Henrik4 aut
700	1	a Kang, Daehee4 aut
700	1	a Yoo, Keun-Young4 aut
700	1	a Noh, Dong-Young4 aut
700	1	a Ahn, Sei-Hyun4 aut
700	1	a Dork, Thilo4 aut
700	1	a Schürmann, Peter4 aut
700	1	a Karstens, Johann H4 aut
700	1	a Hillemanns, Peter4 aut
700	1	a Couch, Fergus J4 aut
700	1	a Olson, Janet4 aut
700	1	a Vachon, Celine4 aut
700	1	a Wang, Xianshu4 aut
700	1	a Cox, Angela4 aut
700	1	a Brock, Ian4 aut
700	1	a Elliott, Graeme4 aut
700	1	a Reed, Malcolm W R4 aut
700	1	a Burwinkel, Barbara4 aut
700	1	a Meindl, Alfons4 aut
700	1	a Brauch, Hiltrud4 aut
700	1	a Hamann, Ute4 aut
700	1	a Ko, Yon-Dschun4 aut
700	1	a Broeks, Annegien4 aut
700	1	a Schmidt, Marjanka K4 aut
700	1	a Van 't Veer, Laura J4 aut
700	1	a Braaf, Linde M4 aut
700	1	a Johnson, Nichola4 aut
700	1	a Fletcher, Olivia4 aut
700	1	a Gibson, Lorna4 aut
700	1	a Peto, Julian4 aut
700	1	a Turnbull, Clare4 aut
700	1	a Seal, Sheila4 aut
700	1	a Renwick, Anthony4 aut
700	1	a Rahman, Nazneen4 aut
700	1	a Wu, Pei-Ei4 aut
700	1	a Yu, Jyh-Cherng4 aut
700	1	a Hsiung, Chia-Ni4 aut
700	1	a Shen, Chen-Yang4 aut
700	1	a Southey, Melissa C4 aut
700	1	a Hopper, John L4 aut
700	1	a Hammet, Fleur4 aut
700	1	a Van Dorpe, Thijs4 aut
700	1	a Dieudonne, Anne-Sophie4 aut
700	1	a Hatse, Sigrid4 aut
700	1	a Lambrechts, Diether4 aut
700	1	a Andrulis, Irene L4 aut
700	1	a Bogdanova, Natalia4 aut
700	1	a Antonenkova, Natalia4 aut
700	1	a Rogov, Juri I4 aut
700	1	a Prokofieva, Daria4 aut
700	1	a Bermisheva, Marina4 aut
700	1	a Khusnutdinova, Elza4 aut
700	1	a van Asperen, Christi J4 aut
700	1	a Tollenaar, Robert A E M4 aut
700	1	a Hooning, Maartje J4 aut
700	1	a Devilee, Peter4 aut
700	1	a Margolin, Sara4 aut
700	1	a Lindblom, Annika4 aut
700	1	a Milne, Roger L4 aut
700	1	a Arias, José Ignacio4 aut
700	1	a Zamora, M Pilar4 aut
700	1	a Benítez, Javier4 aut
700	1	a Severi, Gianluca4 aut
700	1	a Baglietto, Laura4 aut
700	1	a Giles, Graham G4 aut
700	1	a Spurdle, Amanda B4 aut
700	1	a Beesley, Jonathan4 aut
700	1	a Chen, Xiaoqing4 aut
700	1	a Holland, Helene4 aut
700	1	a Healey, Sue4 aut
700	1	a Wang-Gohrke, Shan4 aut
700	1	a Chang-Claude, Jenny4 aut
700	1	a Mannermaa, Arto4 aut
700	1	a Kosma, Veli-Matti4 aut
700	1	a Kauppinen, Jaana4 aut
700	1	a Kataja, Vesa4 aut
700	1	a Agnarsson, Bjarni A4 aut
700	1	a Caligo, Maria A4 aut
700	1	a Godwin, Andrew K4 aut
700	1	a Nevanlinna, Heli4 aut
700	1	a Heikkinen, Tuomas4 aut
700	1	a Fredericksen, Zachary4 aut
700	1	a Lindor, Noralane4 aut
700	1	a Nathanson, Katherine L4 aut
700	1	a Domchek, Susan M4 aut
700	1	a Loman, Niklas4 aut
700	1	a Karlsson, Per4 aut
700	1	a Stenmark Askmalm, Marie4 aut
700	1	a Melin, Beatrice4 aut
700	1	a von Wachenfeldt, Anna4 aut
700	1	a Hogervorst, Frans B L4 aut
700	1	a Verheus, Martijn4 aut
700	1	a Rookus, Matti A4 aut
700	1	a Seynaeve, Caroline4 aut
700	1	a Oldenburg, Rogier A4 aut
700	1	a Ligtenberg, Marjolijn J4 aut
700	1	a Ausems, Margreet G E M4 aut
700	1	a Aalfs, Cora M4 aut
700	1	a Gille, Hans J P4 aut
700	1	a Wijnen, Juul T4 aut
700	1	a Gómez García, Encarna B4 aut
700	1	a Peock, Susan4 aut
700	1	a Cook, Margaret4 aut
700	1	a Oliver, Clare T4 aut
700	1	a Frost, Debra4 aut
700	1	a Luccarini, Craig4 aut
700	1	a Pichert, Gabriella4 aut
700	1	a Davidson, Rosemarie4 aut
700	1	a Chu, Carol4 aut
700	1	a Eccles, Diana4 aut
700	1	a Ong, Kai-Ren4 aut
700	1	a Cook, Jackie4 aut
700	1	a Douglas, Fiona4 aut
700	1	a Hodgson, Shirley4 aut
700	1	a Evans, D Gareth4 aut
700	1	a Eeles, Rosalind4 aut
700	1	a Gold, Bert4 aut
700	1	a Pharoah, Paul D P4 aut
700	1	a Offit, Kenneth4 aut
700	1	a Chenevix-Trench, Georgia4 aut
700	1	a Easton, Douglas F4 aut
710	1 2	a Umeå universitetb Medicinska fakulteten4 pbl0 268483
772	1 8	i channel recordw 18813935
773	0 8	i Värdpublikationt PLoS ONEg 7:6x 1932-6203
856	4 0	u http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-60144
856	4 0	u http://dx.doi.org/10.1371/journal.pone.0035706
856	4 0	u http://umu.diva-portal.org/smash/get/diva2:558164/FULLTEXT01
910	2 s	6 710a Umeå universitet.b Medicinsk-odontologiska fakultetenu Umeå universitet.b Medicinska fakulteten
910	2 s	6 710a Medicinska fakulteten vid Umeå universitetu Umeå universitet.b Medicinska fakulteten
841		5 APISa x ab 171212\|\|0000\|\|\|\|\|001\|\|\|\|\|\|000000e 1
024	7	5 APISa urn:nbn:se:umu:diva-601442 urn
852		5 APISb APIS
856	4 0	5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-60144

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Av författaren/redakt...: Kirchhoff, Tomas; Gaudet, Mia M; Antoniou, Antoni ...; McGuffog, Lesley; Humphreys, Manje ...; Dunning, Alison ...; visa fler...; Bojesen, Stig E; Nordestgaard, Bø ...; Flyger, Henrik; Kang, Daehee; Yoo, Keun-Young; Noh, Dong-Young; Ahn, Sei-Hyun; Dork, Thilo; Schürmann, Peter; Karstens, Johann ...; Hillemanns, Pete ...; Couch, Fergus J; Olson, Janet; Vachon, Celine; Wang, Xianshu; Cox, Angela; Brock, Ian; Elliott, Graeme; Reed, Malcolm W ...; Burwinkel, Barba ...; Meindl, Alfons; Brauch, Hiltrud; Hamann, Ute; Ko, Yon-Dschun; Broeks, Annegien; Schmidt, Marjank ...; Van 't Veer, Lau ...; Braaf, Linde M; Johnson, Nichola; Fletcher, Olivia; Gibson, Lorna; Peto, Julian; Turnbull, Clare; Seal, Sheila; Renwick, Anthony; Rahman, Nazneen; Wu, Pei-Ei; Yu, Jyh-Cherng; Hsiung, Chia-Ni; Shen, Chen-Yang; Southey, Melissa ...; Hopper, John L; Hammet, Fleur; Van Dorpe, Thijs; Dieudonne, Anne- ...; Hatse, Sigrid; Lambrechts, Diet ...; Andrulis, Irene ...; Bogdanova, Natal ...; Antonenkova, Nat ...; Rogov, Juri I; Prokofieva, Dari ...; Bermisheva, Mari ...; Khusnutdinova, E ...; van Asperen, Chr ...; Tollenaar, Rober ...; Hooning, Maartje ...; Devilee, Peter; Margolin, Sara; Lindblom, Annika; Milne, Roger L; Arias, José Igna ...; Zamora, M Pilar; Benítez, Javier; Severi, Gianluca; Baglietto, Laura; Giles, Graham G; Spurdle, Amanda ...; Beesley, Jonatha ...; Chen, Xiaoqing; Holland, Helene; Healey, Sue; Wang-Gohrke, Sha ...; Chang-Claude, Je ...; Mannermaa, Arto; Kosma, Veli-Matt ...; Kauppinen, Jaana; Kataja, Vesa; Agnarsson, Bjarn ...; Caligo, Maria A; Godwin, Andrew K; Nevanlinna, Heli; Heikkinen, Tuoma ...; Fredericksen, Za ...; Lindor, Noralane; Nathanson, Kathe ...; Domchek, Susan M; Loman, Niklas; Karlsson, Per; Stenmark Askmalm ...; Melin, Beatrice; von Wachenfeldt, ...; Hogervorst, Fran ...; Verheus, Martijn; Rookus, Matti A; Seynaeve, Caroli ...; Oldenburg, Rogie ...; Ligtenberg, Marj ...; Ausems, Margreet ...; Aalfs, Cora M; Gille, Hans J P; Wijnen, Juul T; Gómez García, En ...; Peock, Susan; Cook, Margaret; Oliver, Clare T; Frost, Debra; Luccarini, Craig; Pichert, Gabriel ...; Davidson, Rosema ...; Chu, Carol; Eccles, Diana; Ong, Kai-Ren; Cook, Jackie; Douglas, Fiona; Hodgson, Shirley; Evans, D Gareth; Eeles, Rosalind; Gold, Bert; Pharoah, Paul D ...; Offit, Kenneth; Chenevix-Trench, ...; Easton, Douglas ...; visa färre...

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