Genetic Variants in Hormone-Related Genes and Risk of Breast Cancer

doi:10.1371/journal.pone.0069367

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Fältnamn	Indikatorer	Metadata
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001		22080991
003		SE-LIBR
005		20171207151517.0
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008		171207s2013 sw \|\|\|\| o \|\|\|\| \|\|eng c
024	7	a http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2107512 uri
024	7	a urn:nbn:se:uu:diva-2107512 urn
024	7	a 10.1371/journal.pone.00693672 doi
040		a S
041	0	a eng
042		9 EPLK
100	1	a Clendenen, Tess4 aut
245	1 0	a Genetic Variants in Hormone-Related Genes and Risk of Breast Cancerh [Elektronisk resurs]
260		c 2013
500		a Published
506	0	a gratis
520		a Sex hormones play a key role in the development of breast cancer. Certain polymorphic variants (SNPs and repeat polymorphisms) in hormone-related genes are associated with sex hormone levels. However, the relationship observed between these genetic variants and breast cancer risk has been inconsistent. We conducted a case-control study nested within two prospective cohorts to assess the relationship between specific genetic variants in hormone-related genes and breast cancer risk. In total, 1164 cases and 2111 individually-matched controls were included in the study. We did not observe an association between potential functional genetic polymorphisms in the estrogen pathway, SHBG rs6259, ESR1 rs2234693, CYP19 rs10046 and rs4775936, and UGT1A1 rs8175347, or the progesterone pathway, PGR rs1042838, with the risk of breast cancer. Our results suggest that these genetic variants do not have a strong effect on breast cancer risk.
650	7	a Medical and Health Sciences2 hsv
650	7	a Medicin och hälsovetenskap2 hsv
700	1	a Zeleniuch-Jacquotte, Anne4 aut
700	1	a Wirgin, Isaac4 aut
700	1	a Koenig, Karen L.4 aut
700	1	a Afanasyeva, Yelena4 aut
700	1	a Lundin, Eva4 aut
700	1	a Arslan, Alan A.4 aut
700	1	a Axelsson, Tomas4 aut
700	1	a Forsti, Asta4 aut
700	1	a Hallmans, Goran4 aut
700	1	a Hemminki, Kari4 aut
700	1	a Lenner, Per4 aut
700	1	a Roy, Nirmal4 aut
700	1	a Shore, Roy E.4 aut
700	1	a Chen, Yu4 aut
710	1 2	a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl
772	1 8	i channel recordw 19753896
773	0 8	i Värdpublikationt PLoS ONEg 8:7, e69367x 1932-6203
856	4 0	u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-210751
856	4 0	u http://dx.doi.org/10.1371/journal.pone.0069367
856	4 0	u http://uu.diva-portal.org/smash/get/diva2:664234/FULLTEXT01
841		5 APISa x ab 171207\|\|0000\|\|\|\|\|001\|\|\|\|\|\|000000e 1
024	7	5 APISa urn:nbn:se:uu:diva-2107512 urn
852		5 APISb APIS
856	4 0	5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-210751

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Av författaren/redakt...: Clendenen, Tess; Zeleniuch-Jacquo ...; Wirgin, Isaac; Koenig, Karen L.; Afanasyeva, Yele ...; Lundin, Eva; visa fler...; Arslan, Alan A.; Axelsson, Tomas; Forsti, Asta; Hallmans, Goran; Hemminki, Kari; Lenner, Per; Roy, Nirmal; Shore, Roy E.; Chen, Yu; visa färre...

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