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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 15107naa a22042733a 4500 | |
| 001 | 20822938 | |
| 003 | SE-LIBR | |
| 005 | 20170520203837.0 | |
| 007 | cr|||||||||||| | |
| 008 | 170520s2017 sw |||| o |||| ||eng c | |
| 024 | 7 | a http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1347192 uri |
| 024 | 7 | a urn:nbn:se:umu:diva-1347192 urn |
| 024 | 7 | a 10.1038/ncomms149772 doi |
| 040 | a S | |
| 041 | 0 | a eng |
| 042 | 9 EPLK | |
| 100 | 1 | a Justice, Anne E4 aut |
| 245 | 1 0 | a Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traitsh [Elektronisk resurs] |
| 260 | c 2017 | |
| 500 | a Published | |
| 506 | 0 | a gratis |
| 520 | a Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution. | |
| 650 | 7 | a Medical and Health Sciences2 hsv |
| 650 | 7 | a Health Sciences2 hsv |
| 650 | 7 | a Public Health, Global Health, Social Medicine and Epidemiology2 hsv |
| 650 | 7 | a Medicin och hälsovetenskap2 hsv |
| 650 | 7 | a Hälsovetenskaper2 hsv |
| 650 | 7 | a Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi2 hsv |
| 700 | 1 | a Winkler, Thomas W4 aut |
| 700 | 1 | a Feitosa, Mary F4 aut |
| 700 | 1 | a Graff, Misa4 aut |
| 700 | 1 | a Fisher, Virginia A4 aut |
| 700 | 1 | a Young, Kristin4 aut |
| 700 | 1 | a Barata, Llilda4 aut |
| 700 | 1 | a Deng, Xuan4 aut |
| 700 | 1 | a Czajkowski, Jacek4 aut |
| 700 | 1 | a Hadley, David4 aut |
| 700 | 1 | a Ngwa, Julius S4 aut |
| 700 | 1 | a Ahluwalia, Tarunveer S4 aut |
| 700 | 1 | a Chu, Audrey Y4 aut |
| 700 | 1 | a Heard-Costa, Nancy L4 aut |
| 700 | 1 | a Lim, Elise4 aut |
| 700 | 1 | a Perez, Jeremiah4 aut |
| 700 | 1 | a Eicher, John D4 aut |
| 700 | 1 | a Kutalik, Zoltan4 aut |
| 700 | 1 | a Xue, Luting4 aut |
| 700 | 1 | a Mahajan, Anubha4 aut |
| 700 | 1 | a Renström, Frida4 aut |
| 700 | 1 | a Wu, Joseph4 aut |
| 700 | 1 | a Qi, Qibin4 aut |
| 700 | 1 | a Ahmad, Shafqat4 aut |
| 700 | 1 | a Alfred, Tamuno4 aut |
| 700 | 1 | a Amin, Najaf4 aut |
| 700 | 1 | a Bielak, Lawrence F4 aut |
| 700 | 1 | a Bonnefond, Amelie4 aut |
| 700 | 1 | a Bragg, Jennifer4 aut |
| 700 | 1 | a Cadby, Gemma4 aut |
| 700 | 1 | a Chittani, Martina4 aut |
| 700 | 1 | a Coggeshall, Scott4 aut |
| 700 | 1 | a Corre, Tanguy4 aut |
| 700 | 1 | a Direk, Nese4 aut |
| 700 | 1 | a Eriksson, Joel4 aut |
| 700 | 1 | a Fischer, Krista4 aut |
| 700 | 1 | a Gorski, Mathias4 aut |
| 700 | 1 | a Neergaard Harder, Marie4 aut |
| 700 | 1 | a Horikoshi, Momoko4 aut |
| 700 | 1 | a Huang, Tao4 aut |
| 700 | 1 | a Huffman, Jennifer E4 aut |
| 700 | 1 | a Jackson, Anne U4 aut |
| 700 | 1 | a Justesen, Johanne Marie4 aut |
| 700 | 1 | a Kanoni, Stavroula4 aut |
| 700 | 1 | a Kinnunen, Leena4 aut |
| 700 | 1 | a Kleber, Marcus E4 aut |
| 700 | 1 | a Komulainen, Pirjo4 aut |
| 700 | 1 | a Kumari, Meena4 aut |
| 700 | 1 | a Lim, Unhee4 aut |
| 700 | 1 | a Luan, Jian'an4 aut |
| 700 | 1 | a Lyytikainen, Leo-Pekka4 aut |
| 700 | 1 | a Mangino, Massimo4 aut |
| 700 | 1 | a Manichaikul, Ani4 aut |
| 700 | 1 | a Marten, Jonathan4 aut |
| 700 | 1 | a Middelberg, Rita P S4 aut |
| 700 | 1 | a Muller-Nurasyid, Martina4 aut |
| 700 | 1 | a Navarro, Pau4 aut |
| 700 | 1 | a Perusse, Louis4 aut |
| 700 | 1 | a Pervjakova, Natalia4 aut |
| 700 | 1 | a Sarti, Cinzia4 aut |
| 700 | 1 | a Smith, Albert Vernon4 aut |
| 700 | 1 | a Smith, Jennifer A4 aut |
| 700 | 1 | a Stancakova, Alena4 aut |
| 700 | 1 | a Strawbridge, Rona J4 aut |
| 700 | 1 | a Stringham, Heather M4 aut |
| 700 | 1 | a Sung, Yun Ju4 aut |
| 700 | 1 | a Tanaka, Toshiko4 aut |
| 700 | 1 | a Teumer, Alexander4 aut |
| 700 | 1 | a Trompet, Stella4 aut |
| 700 | 1 | a van der Laan, Sander W4 aut |
| 700 | 1 | a van der Most, Peter J4 aut |
| 700 | 1 | a Van Vliet-Ostaptchouk, Jana V4 aut |
| 700 | 1 | a Vedantam, Sailaja L4 aut |
| 700 | 1 | a Verweij, Niek4 aut |
| 700 | 1 | a Vink, Jacqueline M4 aut |
| 700 | 1 | a Vitart, Veronique4 aut |
| 700 | 1 | a Wu, Ying4 aut |
| 700 | 1 | a Yengo, Loic4 aut |
| 700 | 1 | a Zhang, Weihua4 aut |
| 700 | 1 | a Hua Zhao, Jing4 aut |
| 700 | 1 | a Zimmermann, Martina E4 aut |
| 700 | 1 | a Zubair, Niha4 aut |
| 700 | 1 | a Abecasis, Goncalo R4 aut |
| 700 | 1 | a Adair, Linda S4 aut |
| 700 | 1 | a Afaq, Saima4 aut |
| 700 | 1 | a Afzal, Uzma4 aut |
| 700 | 1 | a Bakker, Stephan J L4 aut |
| 700 | 1 | a Bartz, Traci M4 aut |
| 700 | 1 | a Beilby, John4 aut |
| 700 | 1 | a Bergman, Richard N4 aut |
| 700 | 1 | a Bergmann, Sven4 aut |
| 700 | 1 | a Biffar, Reiner4 aut |
| 700 | 1 | a Blangero, John4 aut |
| 700 | 1 | a Boerwinkle, Eric4 aut |
| 700 | 1 | a Bonnycastle, Lori L4 aut |
| 700 | 1 | a Bottinger, Erwin4 aut |
| 700 | 1 | a Braga, Daniele4 aut |
| 700 | 1 | a Buckley, Brendan M4 aut |
| 700 | 1 | a Buyske, Steve4 aut |
| 700 | 1 | a Campbell, Harry4 aut |
| 700 | 1 | a Chambers, John C4 aut |
| 700 | 1 | a Collins, Francis S4 aut0 375177 |
| 700 | 1 | a Curran, Joanne E4 aut |
| 700 | 1 | a de Borst, Gert J4 aut |
| 700 | 1 | a de Craen, Anton J M4 aut |
| 700 | 1 | a de Geus, Eco J C4 aut |
| 700 | 1 | a Dedoussis, George4 aut |
| 700 | 1 | a Delgado, Graciela E4 aut |
| 700 | 1 | a den Ruijter, Hester M4 aut |
| 700 | 1 | a Eiriksdottir, Gudny4 aut |
| 700 | 1 | a Eriksson, Anna L4 aut |
| 700 | 1 | a Esko, Tonu4 aut |
| 700 | 1 | a Faul, Jessica D4 aut |
| 700 | 1 | a Ford, Ian4 aut |
| 700 | 1 | a Forrester, Terrence4 aut |
| 700 | 1 | a Gertow, Karl4 aut |
| 700 | 1 | a Gigante, Bruna4 aut |
| 700 | 1 | a Glorioso, Nicola4 aut |
| 700 | 1 | a Gong, Jian4 aut |
| 700 | 1 | a Grallert, Harald4 aut |
| 700 | 1 | a Grammer, Tanja B4 aut |
| 700 | 1 | a Grarup, Niels4 aut |
| 700 | 1 | a Haitjema, Saskia4 aut |
| 700 | 1 | a Hallmans, Göran4 aut |
| 700 | 1 | a Hamsten, Anders4 aut |
| 700 | 1 | a Hansen, Torben4 aut |
| 700 | 1 | a Harris, Tamara B4 aut |
| 700 | 1 | a Hartman, Catharina A4 aut |
| 700 | 1 | a Hassinen, Maija4 aut |
| 700 | 1 | a Hastie, Nicholas D4 aut |
| 700 | 1 | a Heath, Andrew C4 aut |
| 700 | 1 | a Hernandez, Dena4 aut |
| 700 | 1 | a Hindorff, Lucia4 aut |
| 700 | 1 | a Hocking, Lynne J4 aut |
| 700 | 1 | a Hollensted, Mette4 aut |
| 700 | 1 | a Holmen, Oddgeir L4 aut |
| 700 | 1 | a Homuth, Georg4 aut |
| 700 | 1 | a Jan Hottenga, Jouke4 aut |
| 700 | 1 | a Huang, Jie4 aut |
| 700 | 1 | a Hung, Joseph4 aut |
| 700 | 1 | a Hutri-Kahonen, Nina4 aut |
| 700 | 1 | a Ingelsson, Erik4 aut |
| 700 | 1 | a James, Alan L4 aut |
| 700 | 1 | a Jansson, John-Olov4 aut |
| 700 | 1 | a Jarvelin, Marjo-Riitta4 aut |
| 700 | 1 | a Jhun, Min A4 aut |
| 700 | 1 | a Jorgensen, Marit E4 aut |
| 700 | 1 | a Juonala, Markus4 aut |
| 700 | 1 | a Kahonen, Mika4 aut |
| 700 | 1 | a Karlsson, Magnus4 aut |
| 700 | 1 | a Koistinen, Heikki A4 aut |
| 700 | 1 | a Kolcic, Ivana4 aut |
| 700 | 1 | a Kolovou, Genovefa4 aut |
| 700 | 1 | a Kooperberg, Charles4 aut |
| 700 | 1 | a Kramer, Bernhard K4 aut |
| 700 | 1 | a Kuusisto, Johanna4 aut |
| 700 | 1 | a Kvaloy, Kirsti4 aut |
| 700 | 1 | a Lakka, Timo A4 aut |
| 700 | 1 | a Langenberg, Claudia4 aut |
| 700 | 1 | a Launer, Lenore J4 aut |
| 700 | 1 | a Leander, Karin4 aut |
| 700 | 1 | a Lee, Nanette R4 aut |
| 700 | 1 | a Lind, Lars4 aut |
| 700 | 1 | a Lindgren, Cecilia M4 aut |
| 700 | 1 | a Linneberg, Allan4 aut |
| 700 | 1 | a Lobbens, Stephane4 aut |
| 700 | 1 | a Loh, Marie4 aut |
| 700 | 1 | a Lorentzon, Mattias4 aut |
| 700 | 1 | a Luben, Robert4 aut |
| 700 | 1 | a Lubke, Gitta4 aut |
| 700 | 1 | a Ludolph-Donislawski, Anja4 aut |
| 700 | 1 | a Lupoli, Sara4 aut |
| 700 | 1 | a Madden, Pamela A F4 aut |
| 700 | 1 | a Mannikko, Reija4 aut |
| 700 | 1 | a Marques-Vidal, Pedro4 aut |
| 700 | 1 | a Martin, Nicholas G4 aut |
| 700 | 1 | a McKenzie, Colin A4 aut |
| 700 | 1 | a McKnight, Barbara4 aut |
| 700 | 1 | a Mellstrom, Dan4 aut |
| 700 | 1 | a Menni, Cristina4 aut |
| 700 | 1 | a Montgomery, Grant W4 aut |
| 700 | 1 | a Musk, Aw Bill4 aut |
| 700 | 1 | a Narisu, Narisu4 aut |
| 700 | 1 | a Nauck, Matthias4 aut |
| 700 | 1 | a Nolte, Ilja M4 aut |
| 700 | 1 | a Oldehinkel, Albertine J4 aut |
| 700 | 1 | a Olden, Matthias4 aut |
| 700 | 1 | a Ong, Ken K4 aut |
| 700 | 1 | a Padmanabhan, Sandosh4 aut |
| 700 | 1 | a Peyser, Patricia A4 aut |
| 700 | 1 | a Pisinger, Charlotta4 aut |
| 700 | 1 | a Porteous, David J4 aut |
| 700 | 1 | a Raitakari, Olli T4 aut |
| 700 | 1 | a Rankinen, Tuomo4 aut |
| 700 | 1 | a Rao, D C4 aut |
| 700 | 1 | a Rasmussen-Torvik, Laura J4 aut |
| 700 | 1 | a Rawal, Rajesh4 aut |
| 700 | 1 | a Rice, Treva4 aut |
| 700 | 1 | a Ridker, Paul M4 aut |
| 700 | 1 | a Rose, Lynda M4 aut |
| 700 | 1 | a Bien, Stephanie A4 aut |
| 700 | 1 | a Rudan, Igor4 aut |
| 700 | 1 | a Sanna, Serena4 aut |
| 700 | 1 | a Sarzynski, Mark A4 aut |
| 700 | 1 | a Sattar, Naveed4 aut |
| 700 | 1 | a Savonen, Kai4 aut |
| 700 | 1 | a Schlessinger, David4 aut |
| 700 | 1 | a Scholtens, Salome4 aut |
| 700 | 1 | a Schurmann, Claudia4 aut |
| 700 | 1 | a Scott, Robert A4 aut |
| 700 | 1 | a Sennblad, Bengt4 aut |
| 700 | 1 | a Siemelink, Marten A4 aut |
| 700 | 1 | a Silbernagel, Gunther4 aut |
| 700 | 1 | a Slagboom, P Eline4 aut |
| 700 | 1 | a Snieder, Harold4 aut |
| 700 | 1 | a Staessen, Jan A4 aut |
| 700 | 1 | a Stott, David J4 aut |
| 700 | 1 | a Swertz, Morris A4 aut |
| 700 | 1 | a Swift, Amy J4 aut |
| 700 | 1 | a Taylor, Kent D4 aut |
| 700 | 1 | a Tayo, Bamidele O4 aut |
| 700 | 1 | a Thorand, Barbara4 aut |
| 700 | 1 | a Thuillier, Dorothee4 aut |
| 700 | 1 | a Tuomilehto, Jaakko4 aut |
| 700 | 1 | a Uitterlinden, Andre G4 aut |
| 700 | 1 | a Vandenput, Liesbeth4 aut |
| 700 | 1 | a Vohl, Marie-Claude4 aut |
| 700 | 1 | a Volzke, Henry4 aut |
| 700 | 1 | a Vonk, Judith M4 aut |
| 700 | 1 | a Waeber, Gerard4 aut |
| 700 | 1 | a Waldenberger, Melanie4 aut |
| 700 | 1 | a Westendorp, R G J4 aut |
| 700 | 1 | a Wild, Sarah4 aut |
| 700 | 1 | a Willemsen, Gonneke4 aut |
| 700 | 1 | a Wolffenbuttel, Bruce H R4 aut |
| 700 | 1 | a Wong, Andrew4 aut |
| 700 | 1 | a Wright, Alan F4 aut |
| 700 | 1 | a Zhao, Wei4 aut |
| 700 | 1 | a Zillikens, M Carola4 aut |
| 700 | 1 | a Baldassarre, Damiano4 aut |
| 700 | 1 | a Balkau, Beverley4 aut |
| 700 | 1 | a Bandinelli, Stefania4 aut |
| 700 | 1 | a Boger, Carsten A4 aut |
| 700 | 1 | a Boomsma, Dorret I4 aut |
| 700 | 1 | a Bouchard, Claude4 aut |
| 700 | 1 | a Bruinenberg, Marcel4 aut |
| 700 | 1 | a Chasman, Daniel I4 aut |
| 700 | 1 | a Chen, Yii-DerIda4 aut |
| 700 | 1 | a Chines, Peter S4 aut |
| 700 | 1 | a Cooper, Richard S4 aut |
| 700 | 1 | a Cucca, Francesco4 aut |
| 700 | 1 | a Cusi, Daniele4 aut |
| 700 | 1 | a Faire, Ulf de4 aut |
| 700 | 1 | a Ferrucci, Luigi4 aut |
| 700 | 1 | a Franks, Paul W4 aut |
| 700 | 1 | a Froguel, Philippe4 aut |
| 700 | 1 | a Gordon-Larsen, Penny4 aut |
| 700 | 1 | a Grabe, Hans-Jorgen4 aut |
| 700 | 1 | a Gudnason, Vilmundur4 aut |
| 700 | 1 | a Haiman, Christopher A4 aut |
| 700 | 1 | a Hayward, Caroline4 aut |
| 700 | 1 | a Hveem, Kristian4 aut |
| 700 | 1 | a Johnson, Andrew D4 aut |
| 700 | 1 | a Wouter Jukema, J4 aut |
| 700 | 1 | a Kardia, Sharon L R4 aut |
| 700 | 1 | a Kivimaki, Mika4 aut |
| 700 | 1 | a Kooner, Jaspal S4 aut |
| 700 | 1 | a Kuh, Diana4 aut |
| 700 | 1 | a Laakso, Markku4 aut |
| 700 | 1 | a Lehtimaki, Terho4 aut |
| 700 | 1 | a Marchand, Loic Le4 aut |
| 700 | 1 | a Marz, Winfried4 aut |
| 700 | 1 | a McCarthy, Mark I4 aut |
| 700 | 1 | a Metspalu, Andres4 aut |
| 700 | 1 | a Morris, Andrew P4 aut |
| 700 | 1 | a Ohlsson, Claes4 aut |
| 700 | 1 | a Palmer, Lyle J4 aut |
| 700 | 1 | a Pasterkamp, Gerard4 aut |
| 700 | 1 | a Pedersen, Oluf4 aut |
| 700 | 1 | a Peters, Annette4 aut |
| 700 | 1 | a Peters, Ulrike4 aut |
| 700 | 1 | a Polasek, Ozren4 aut |
| 700 | 1 | a Psaty, Bruce M4 aut |
| 700 | 1 | a Qi, Lu4 aut |
| 700 | 1 | a Rauramaa, Rainer4 aut |
| 700 | 1 | a Smith, Blair H4 aut |
| 700 | 1 | a Sorensen, Thorkild I A4 aut |
| 700 | 1 | a Strauch, Konstantin4 aut |
| 700 | 1 | a Tiemeier, Henning4 aut |
| 700 | 1 | a Tremoli, Elena4 aut |
| 700 | 1 | a van der Harst, Pim4 aut |
| 700 | 1 | a Vestergaard, Henrik4 aut |
| 700 | 1 | a Vollenweider, Peter4 aut |
| 700 | 1 | a Wareham, Nicholas J4 aut |
| 700 | 1 | a Weir, David R4 aut |
| 700 | 1 | a Whitfield, John B4 aut |
| 700 | 1 | a Wilson, James F4 aut |
| 700 | 1 | a Tyrrell, Jessica4 aut |
| 700 | 1 | a Frayling, Timothy M4 aut |
| 700 | 1 | a Barroso, Ines4 aut |
| 700 | 1 | a Boehnke, Michael4 aut |
| 700 | 1 | a Deloukas, Panagiotis4 aut |
| 700 | 1 | a Fox, Caroline S4 aut |
| 700 | 1 | a Hirschhorn, Joel N4 aut |
| 700 | 1 | a Hunter, David J4 aut |
| 700 | 1 | a Spector, Tim D4 aut |
| 700 | 1 | a Strachan, David P4 aut |
| 700 | 1 | a van Duijn, Cornelia M4 aut |
| 700 | 1 | a Heid, Iris M4 aut |
| 700 | 1 | a Mohlke, Karen L4 aut |
| 700 | 1 | a Marchini, Jonathan4 aut |
| 700 | 1 | a Loos, Ruth J F4 aut |
| 700 | 1 | a Kilpelainen, Tuomas O4 aut |
| 700 | 1 | a Liu, Ching-Ti4 aut |
| 700 | 1 | a Borecki, Ingrid B4 aut |
| 700 | 1 | a North, Kari E4 aut |
| 700 | 1 | a Cupples, L Adrienne4 aut |
| 710 | 1 2 | a Umeå universitetb Medicinska fakulteten4 pbl0 268483 |
| 710 | 1 2 | a Umeå universitetb Medicinska fakulteten4 pbl0 268483 |
| 772 | 1 8 | i channel recordw 18813935 |
| 773 | 0 8 | i Värdpublikationt Nature Communicationsg 8, 14977-14977x 2041-1723 |
| 856 | 4 0 | u http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-134719 |
| 856 | 4 0 | u http://dx.doi.org/10.1038/ncomms14977 |
| 856 | 4 0 | u http://umu.diva-portal.org/smash/get/diva2:1096917/FULLTEXT01 |
| 900 | 1 s | 6 700a Collins, Francis Sellarsu Collins, Francis S. |
| 900 | 1 s | 6 700a Collins, Francis,d 1950-u Collins, Francis S. |
| 910 | 2 s | 6 710,710a Umeå universitet.b Medicinsk-odontologiska fakultetenu Umeå universitet.b Medicinska fakulteten |
| 910 | 2 s | 6 710,710a Medicinska fakulteten vid Umeå universitetu Umeå universitet.b Medicinska fakulteten |
| 841 | 5 APISa x ab 170520||0000|||||001||||||000000e 1 | |
| 024 | 7 | 5 APISa urn:nbn:se:umu:diva-1347192 urn |
| 852 | 5 APISb APIS | |
| 856 | 4 0 | 5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-134719 |
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