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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 13139naa a22026293a 4500 | |
| 001 | 22116046 | |
| 003 | SE-LIBR | |
| 005 | 20171213154611.0 | |
| 007 | cr|||||||||||| | |
| 008 | 171213s2011 sw |||| o |||| ||eng c | |
| 024 | 7 | a http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-762132 uri |
| 024 | 7 | a urn:nbn:se:liu:diva-762132 urn |
| 024 | 7 | a 10.1186/bcr30522 doi |
| 040 | a S | |
| 041 | 0 | a eng |
| 042 | 9 EPLK | |
| 100 | 1 | a Mulligan, Anna Marie4 aut |
| 245 | 1 0 | a Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2h [Elektronisk resurs] |
| 260 | b BioMed Centralc 2011 | |
| 500 | a <p>Funding Agencies|Breast Cancer Research Foundation||MacDonald Family Foundation||Komen Foundation||NIH, NCI|P50 CA 058207|Avon Foundation||UCSF Helen Diller Family Comprehensive Cancer Center UK||CRUK||Russian Federation for Basic Research|10-04-9260110-04-9211011-04-00227|Federal Agency for Science and Innovations|02.740.11.0780|Commission of the European Communities|PITN-GA-2009-238132|Royal Society|JP090615|US National Cancer Institute||Westat, Inc., Rockville, MD||Starr Cancer Consortium||Norman and Carol Stone Genetic Research Fund||Robert and Kate Niehaus Clinical Genetics Initiative at MSKCC||NIH|CA116167CA128978|Research Excellence (SPORE) in Breast Cancer|CA116201|Ministero della Salute|RFPS 2006-5-341353ACC2/R6.9|Kathleen Cuningham Consortium for Research into Familial Breast Cancer (kConFab)||Icelandic Association||Landspitali University Hospital||NEYE Foundation||Deutsches Krebsforschungszentrum (DKFZ)||Associazione Italiana per la Ricerca sul Cancro|4017|Italian citizens||Fondazione Italiana per la Ricerca sul Cancro||Cancer Research UK|C12292/A11174C1287/A10118C1287/A11990C5047/A8385|NIHR||Eileen Stein Jacoby Fund||University of Kansas Cancer Center||Kansas Bioscience Authority Eminent Scholar Program||Familial Cancer Registry (CI)||Tissue Culture Shared Registry at Georgetown University (NIH/NCI)|P30-CA051008|Cancer Genetics Network|HHSN261200744000C|Swing Fore the Cure||German Consortium of Hereditary Breast and Ovarian Cancer (GC-HBOC) GC-HBOC||German Cancer Aid|109076|Centre of Molecular Medicine Cologne (CMMC)||Ligue National Contre le Cancer||Association for International Cancer|AICR-07-0454|Association "Le cancer du sein, parlons-en!" Award||European Community|223175 (HEALTH-F2-2009-223175)|National Cancer Institute, National Institutes of Health|RFA-CA-06-503|Liepajas municipal council|||NO2-CP-11019-50||N02-CP-65504||U01CA69631||5U01CA113916|</p> | |
| 500 | a Published | |
| 506 | 0 | a gratis |
| 520 | a Introduction: Previous studies have demonstrated that common breast cancer susceptibility alleles are differentially associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. It is currently unknown how these alleles are associated with different breast cancer subtypes in BRCA1 and BRCA2 mutation carriers defined by estrogen (ER) or progesterone receptor (PR) status of the tumour. less thanbrgreater than less thanbrgreater thanMethods: We used genotype data on up to 11,421 BRCA1 and 7,080 BRCA2 carriers, of whom 4,310 had been affected with breast cancer and had information on either ER or PR status of the tumour, to assess the associations of 12 loci with breast cancer tumour characteristics. Associations were evaluated using a retrospective cohort approach. less thanbrgreater than less thanbrgreater thanResults: The results suggested stronger associations with ER-positive breast cancer than ER-negative for 11 loci in both BRCA1 and BRCA2 carriers. Among BRCA1 carriers, single nucleotide polymorphism (SNP) rs2981582 (FGFR2) exhibited the biggest difference based on ER status (per-allele hazard ratio (HR) for ER-positive = 1.35, 95% CI: 1.17 to 1.56 vs HR = 0.91, 95% CI: 0.85 to 0.98 for ER-negative, P-heterogeneity = 6.5 x 10(-6)). In contrast, SNP rs2046210 at 6q25.1 near ESR1 was primarily associated with ER-negative breast cancer risk for both BRCA1 and BRCA2 carriers. In BRCA2 carriers, SNPs in FGFR2, TOX3, LSP1, SLC4A7/NEK10, 5p12, 2q35, and 1p11.2 were significantly associated with ER-positive but not ER-negative disease. Similar results were observed when differentiating breast cancer cases by PR status. less thanbrgreater than less thanbrgreater thanConclusions: The associations of the 12 SNPs with risk for BRCA1 and BRCA2 carriers differ by ER-positive or ER-negative breast cancer status. The apparent differences in SNP associations between BRCA1 and BRCA2 carriers, and non-carriers, may be explicable by differences in the prevalence of tumour subtypes. As more risk modifying variants are identified, incorporating these associations into breast cancer subtype-specific risk models may improve clinical management for mutation carriers. | |
| 650 | 7 | a Social Sciences2 hsv |
| 650 | 7 | a Samhällsvetenskap2 hsv |
| 650 | 7 | a SOCIAL SCIENCES2 svep |
| 650 | 7 | a SAMHÄLLSVETENSKAP2 svep |
| 700 | 1 | a Couch, Fergus J4 aut |
| 700 | 1 | a Barrowdale, Daniel4 aut |
| 700 | 1 | a Domchek, Susan M4 aut |
| 700 | 1 | a Eccles, Diana4 aut |
| 700 | 1 | a Nevanlinna, Heli4 aut |
| 700 | 1 | a Ramus, Susan J4 aut |
| 700 | 1 | a Robson, Mark4 aut |
| 700 | 1 | a Sherman, Mark4 aut |
| 700 | 1 | a Spurdle, Amanda B4 aut |
| 700 | 1 | a Wappenschmidt, Barbara4 aut |
| 700 | 1 | a Lee, Andrew4 aut |
| 700 | 1 | a McGuffog, Lesley4 aut |
| 700 | 1 | a Healey, Sue4 aut |
| 700 | 1 | a Sinilnikova, Olga M4 aut |
| 700 | 1 | a Janavicius, Ramunas4 aut |
| 700 | 1 | a Hansen, Thomas V O4 aut |
| 700 | 1 | a Nielsen, Finn C4 aut |
| 700 | 1 | a Ejlertsen, Bent4 aut |
| 700 | 1 | a Osorio, Ana4 aut |
| 700 | 1 | a Munoz-Repeto, Ivan4 aut |
| 700 | 1 | a Duran, Mercedes4 aut |
| 700 | 1 | a Godino, Javier4 aut |
| 700 | 1 | a Pertesi, Maroulio4 aut |
| 700 | 1 | a Benitez, Javier4 aut |
| 700 | 1 | a Peterlongo, Paolo4 aut |
| 700 | 1 | a Manoukian, Siranoush4 aut |
| 700 | 1 | a Peissel, Bernard4 aut |
| 700 | 1 | a Zaffaroni, Daniela4 aut |
| 700 | 1 | a Cattaneo, Elisa4 aut |
| 700 | 1 | a Bonanni, Bernardo4 aut |
| 700 | 1 | a Viel, Alessandra4 aut |
| 700 | 1 | a Pasini, Barbara4 aut |
| 700 | 1 | a Papi, Laura4 aut |
| 700 | 1 | a Ottini, Laura4 aut |
| 700 | 1 | a Savarese, Antonella4 aut |
| 700 | 1 | a Bernard, Loris4 aut |
| 700 | 1 | a Radice, Paolo4 aut |
| 700 | 1 | a Hamann, Ute4 aut |
| 700 | 1 | a Verheus, Martijn4 aut |
| 700 | 1 | a Meijers-Heijboer, Hanne E J4 aut |
| 700 | 1 | a Wijnen, Juul4 aut |
| 700 | 1 | a Gomez Garcia, EncarnaB4 aut |
| 700 | 1 | a Nelen, Marcel R4 aut |
| 700 | 1 | a Kets, C Marleen4 aut |
| 700 | 1 | a Seynaeve, Caroline4 aut |
| 700 | 1 | a Tilanus-Linthorst, Madeleine M A4 aut |
| 700 | 1 | a van der Luijt, Rob B4 aut |
| 700 | 1 | a van Os, Theo4 aut |
| 700 | 1 | a Rookus, Matti4 aut |
| 700 | 1 | a Frost, Debra4 aut |
| 700 | 1 | a Jones, J Louise4 aut |
| 700 | 1 | a Evans, D Gareth4 aut |
| 700 | 1 | a Lalloo, Fiona4 aut |
| 700 | 1 | a Eeles, Ros4 aut |
| 700 | 1 | a Izatt, Louise4 aut |
| 700 | 1 | a Adlard, Julian4 aut |
| 700 | 1 | a Davidson, Rosemarie4 aut |
| 700 | 1 | a Cook, Jackie4 aut |
| 700 | 1 | a Donaldson, Alan4 aut |
| 700 | 1 | a Dorkins, Huw4 aut |
| 700 | 1 | a Gregory, Helen4 aut |
| 700 | 1 | a Eason, Jacqueline4 aut |
| 700 | 1 | a Houghton, Catherine4 aut |
| 700 | 1 | a Barwell, Julian4 aut |
| 700 | 1 | a E Side, Lucy4 aut |
| 700 | 1 | a McCann, Emma4 aut |
| 700 | 1 | a Murray, Alex4 aut |
| 700 | 1 | a Peock, Susan4 aut |
| 700 | 1 | a K Godwin, Andrew4 aut |
| 700 | 1 | a K Schmutzler, Rita4 aut |
| 700 | 1 | a Rhiem, Kerstin4 aut |
| 700 | 1 | a Engel, Christoph4 aut |
| 700 | 1 | a Meindl, Alfons4 aut |
| 700 | 1 | a Ruehl, Ina4 aut |
| 700 | 1 | a Arnold, Norbert4 aut |
| 700 | 1 | a Niederacher, Dieter4 aut |
| 700 | 1 | a Sutter, Christian4 aut |
| 700 | 1 | a Deissler, Helmut4 aut |
| 700 | 1 | a Gadzicki, Dorothea4 aut |
| 700 | 1 | a Kast, Karin4 aut |
| 700 | 1 | a Preisler-Adams, Sabine4 aut |
| 700 | 1 | a Varon-Mateeva, Raymonda4 aut |
| 700 | 1 | a Schoenbuchner, Ines4 aut |
| 700 | 1 | a Fiebig, Britta4 aut |
| 700 | 1 | a Heinritz, Wolfram4 aut |
| 700 | 1 | a Schaefer, Dieter4 aut |
| 700 | 1 | a Gevensleben, Heidrun4 aut |
| 700 | 1 | a Caux-Moncoutier, Virginie4 aut |
| 700 | 1 | a Fassy-Colcombet, Marion4 aut |
| 700 | 1 | a Cornelis, Francois4 aut |
| 700 | 1 | a Mazoyer, Sylvie4 aut |
| 700 | 1 | a Leone, Melanie4 aut |
| 700 | 1 | a Boutry-Kryza, Nadia4 aut |
| 700 | 1 | a Hardouin, Agnes4 aut |
| 700 | 1 | a Berthet, Pascaline4 aut |
| 700 | 1 | a Muller, Daniele4 aut |
| 700 | 1 | a Fricker, Jean-Pierre4 aut |
| 700 | 1 | a Mortemousque, Isabelle4 aut |
| 700 | 1 | a Pujol, Pascal4 aut |
| 700 | 1 | a Coupier, Isabelle4 aut |
| 700 | 1 | a Lebrun, Marine4 aut |
| 700 | 1 | a Kientz, Caroline4 aut |
| 700 | 1 | a Longy, Michel4 aut |
| 700 | 1 | a Sevenet, Nicolas4 aut |
| 700 | 1 | a Stoppa-Lyonnet, Dominique4 aut |
| 700 | 1 | a Isaacs, Claudine4 aut |
| 700 | 1 | a Caldes, Trinidad4 aut |
| 700 | 1 | a de la Hoya, Miguel4 aut |
| 700 | 1 | a Heikkinen, Tuomas4 aut |
| 700 | 1 | a Aittomaki, Kristiina4 aut |
| 700 | 1 | a Blanco, Ignacio4 aut |
| 700 | 1 | a Lazaro, Conxi4 aut |
| 700 | 1 | a B Barkardottir, Rosa4 aut |
| 700 | 1 | a Soucy, Penny4 aut |
| 700 | 1 | a Dumont, Martine4 aut |
| 700 | 1 | a Simard, Jacques4 aut |
| 700 | 1 | a Montagna, Marco4 aut |
| 700 | 1 | a Tognazzo, Silvia4 aut |
| 700 | 1 | a DAndrea, Emma4 aut |
| 700 | 1 | a Fox, Stephen4 aut |
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| 700 | 1 | a Rebbeck, Tim4 aut |
| 700 | 1 | a I Olopade, Olufunmilayo4 aut |
| 700 | 1 | a N Weitzel, Jeffrey4 aut |
| 700 | 1 | a T Lynch, Henry4 aut |
| 700 | 1 | a A Ganz, Patricia4 aut |
| 700 | 1 | a E Tomlinson, Gail4 aut |
| 700 | 1 | a Wang, Xianshu4 aut |
| 700 | 1 | a Fredericksen, Zachary4 aut |
| 700 | 1 | a S Pankratz, Vernon4 aut |
| 700 | 1 | a M Lindor, Noralane4 aut |
| 700 | 1 | a Szabo, Csilla4 aut |
| 700 | 1 | a Offit, Kenneth4 aut |
| 700 | 1 | a Sakr, Rita4 aut |
| 700 | 1 | a Gaudet, Mia4 aut |
| 700 | 1 | a Bhatia, Jasmine4 aut |
| 700 | 1 | a Kauff, Noah4 aut |
| 700 | 1 | a F Singer, Christian4 aut |
| 700 | 1 | a Tea, Muy-Kheng4 aut |
| 700 | 1 | a Gschwantler-Kaulich, Daphne4 aut |
| 700 | 1 | a Fink-Retter, Anneliese4 aut |
| 700 | 1 | a L Mai, Phuong4 aut |
| 700 | 1 | a H Greene, Mark4 aut |
| 700 | 1 | a Imyanitov, Evgeny4 aut |
| 700 | 1 | a P OMalley, Frances4 aut |
| 700 | 1 | a Ozcelik, Hilmi4 aut |
| 700 | 1 | a Glendon, Gordon4 aut |
| 700 | 1 | a Gerdes, Anne-Marie4 aut |
| 700 | 1 | a Thomassen, Mads4 aut |
| 700 | 1 | a A Kruse, Torben4 aut |
| 700 | 1 | a Birk Jensen, Uffe4 aut |
| 700 | 1 | a Skytte, Anne-Bine4 aut |
| 700 | 1 | a A Caligo, Maria4 aut |
| 700 | 1 | a Soller, Maria4 aut |
| 700 | 1 | a Henriksson, Karin4 aut |
| 700 | 1 | a Anna Wachenfeldt, von4 aut |
| 700 | 1 | a Arver, Brita4 aut |
| 700 | 1 | a Stenmark Askmalm, Marie4 aut |
| 700 | 1 | a Karlsson, Per4 aut |
| 700 | 1 | a Chun Ding, Yuan4 aut |
| 700 | 1 | a L Neuhausen, Susan4 aut |
| 700 | 1 | a Beattie, Mary4 aut |
| 700 | 1 | a D P Pharoah, Paul4 aut |
| 700 | 1 | a B Moysich, Kirsten4 aut |
| 700 | 1 | a L Nathanson, Katherine4 aut |
| 700 | 1 | a Y Karlan, Beth4 aut |
| 700 | 1 | a Gross, Jenny4 aut |
| 700 | 1 | a M John, Esther4 aut |
| 700 | 1 | a B Daly, Mary4 aut |
| 700 | 1 | a M Buys, Saundra4 aut |
| 700 | 1 | a C Southey, Melissa4 aut |
| 700 | 1 | a L Hopper, John4 aut |
| 700 | 1 | a Beth Terry, Mary4 aut |
| 700 | 1 | a Chung, Wendy4 aut |
| 700 | 1 | a F Miron, Alexander4 aut |
| 700 | 1 | a Goldgar, David4 aut |
| 700 | 1 | a Chenevix-Trench, Georgia4 aut |
| 700 | 1 | a F Easton, Douglas4 aut |
| 700 | 1 | a L Andrulis, Irene4 aut |
| 700 | 1 | a C Antoniou, Antonis4 aut |
| 710 | 1 2 | a Linköpings universitetb Institutionen för klinisk och experimentell medicin4 pbl0 347333 |
| 710 | 1 2 | a Linköpings universitetb Hälsouniversitetet4 pbl |
| 710 | 1 2 | a Östergötlands Läns Landstingb Diagnostikcentrum4 pbl |
| 772 | 1 8 | i channel recordw 18478042 |
| 773 | 0 8 | i Värdpublikationt Breast Cancer Researchg 13:6x 1465-5411 |
| 856 | 4 0 | u http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-76213 |
| 856 | 4 0 | u http://dx.doi.org/10.1186/bcr3052 |
| 856 | 4 0 | u http://liu.diva-portal.org/smash/get/diva2:513047/FULLTEXT01 |
| 910 | 2 s | 6 710a IKEu Linköpings universitet.b Institutionen för klinisk och experimentell medicin |
| 910 | 2 s | 6 710a Linköping University.b Department of Clinical and Experimental Medicineu Linköpings universitet.b Institutionen för klinisk och experimentell medicin |
| 910 | 2 s | 6 710a Linköping University.b Faculty of Health Sciences.b Department of Clinical and Experimental Medicineu Linköpings universitet.b Institutionen för klinisk och experimentell medicin |
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| 024 | 7 | 5 APISa urn:nbn:se:liu:diva-762132 urn |
| 852 | 5 APISb APIS | |
| 856 | 4 0 | 5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-76213 |
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