onr:"22094711"
Sökning: onr:"22094711" > The Crest Phenotype...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02930naa a22005413a 4500 | |
| 001 | 22094711 | |
| 003 | SE-LIBR | |
| 005 | 20171208151916.0 | |
| 007 | cr|||||||||||| | |
| 008 | 171208s2012 sw |||| o |||| ||eng c | |
| 024 | 7 | a http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1776342 uri |
| 024 | 7 | a urn:nbn:se:uu:diva-1776342 urn |
| 024 | 7 | a 10.1371/journal.pone.00340122 doi |
| 040 | a S | |
| 041 | 0 | a eng |
| 042 | 9 EPLK | |
| 100 | 1 | a Wang, Yanqiang4 aut |
| 245 | 1 0 | a The Crest Phenotype in Chicken Is Associated with Ectopic Expression of HOXC8 in Cranial Skinh [Elektronisk resurs] |
| 260 | c 2012 | |
| 500 | a Published | |
| 506 | 0 | a gratis |
| 520 | a The Crest phenotype is characterised by a tuft of elongated feathers atop the head. A similar phenotype is also seen in several wild bird species. Crest shows an autosomal incompletely dominant mode of inheritance and is associated with cerebral hernia. Here we show, using linkage analysis and genome-wide association, that Crest is located on the E22C19W28 linkage group and that it shows complete association to the HOXC-cluster on this chromosome. Expression analysis of tissues from Crested and non-crested chickens, representing 26 different breeds, revealed that HOXC8, but not HOXC12 or HOXC13, showed ectopic expression in cranial skin during embryonic development. We propose that Crest is caused by a cis-acting regulatory mutation underlying the ectopic expression of HOXC8. However, the identification of the causative mutation(s) has to await until a method becomes available for assembling this chromosomal region. Crest is unfortunately located in a genomic region that has so far defied all attempts to establish a contiguous sequence. | |
| 650 | 7 | a Medical and Health Sciences2 hsv |
| 650 | 7 | a Medicin och hälsovetenskap2 hsv |
| 700 | 1 | a Gao, Yu4 aut |
| 700 | 1 | a Imsland, Freyja4 aut |
| 700 | 1 | a Gu, Xiaorong4 aut |
| 700 | 1 | a Feng, Chungang4 aut |
| 700 | 1 | a Liu, Ranran4 aut |
| 700 | 1 | a Song, Chi4 aut |
| 700 | 1 | a Tixier-Boichard, Michele4 aut |
| 700 | 1 | a Gourichon, David4 aut |
| 700 | 1 | a Li, Qingyuan4 aut |
| 700 | 1 | a Chen, Kuanwei4 aut |
| 700 | 1 | a Li, Huifang4 aut |
| 700 | 1 | a Andersson, Leif4 aut |
| 700 | 1 | a Hu, Xiaoxiang4 aut |
| 700 | 1 | a Li, Ning4 aut |
| 710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
| 772 | 1 8 | i channel recordw 19753896 |
| 773 | 0 8 | i Värdpublikationt PLoS ONEg 7:4, e34012x 1932-6203 |
| 856 | 4 0 | u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-177634 |
| 856 | 4 0 | u http://dx.doi.org/10.1371/journal.pone.0034012 |
| 856 | 4 0 | u http://uu.diva-portal.org/smash/get/diva2:541388/FULLTEXT01 |
| 841 | 5 APISa x ab 171208||0000|||||001||||||000000e 1 | |
| 024 | 7 | 5 APISa urn:nbn:se:uu:diva-1776342 urn |
| 852 | 5 APISb APIS | |
| 856 | 4 0 | 5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-177634 |
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