Moderate nucleotide diversity in the Atlantic herring is associated with a low mutation rate

doi:10.7554/eLife.23907

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Fältnamn	Indikatorer	Metadata
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024	7	a urn:nbn:se:uu:diva-3334092 urn
024	7	a 10.7554/eLife.239072 doi
040		a S
041	0	a eng
042		9 EPLK
100	1	a Feng, Chungang4 aut
245	1 0	a Moderate nucleotide diversity in the Atlantic herring is associated with a low mutation rateh [Elektronisk resurs]
260		b ELIFE SCIENCES PUBLICATIONS LTDc 2017
500		a Published
500		a EU, Europeiska forskningsrådet [Bateson]
506	0	a gratis
520		a The Atlantic herring is one of the most abundant vertebrates on earth but its nucleotide diversity is moderate (pi = 0.3%), only three-fold higher than in human. Here, we present a pedigree-based estimation of the mutation rate in this species. Based on whole-genome sequencing of four parents and 12 offspring, the estimated mutation rate is 2.0 x 10(-9) per base per generation. We observed a high degree of parental mosaicism indicating that a large fraction of these de novo mutations occurred during early germ cell development. The estimated mutation rate the lowest among vertebrates analyzed to date - partially explains the discrepancy between the rather low nucleotide diversity in herring and its huge census population size. But a species like the herring will never reach its expected nucleotide diversity because of fluctuations in population size over the millions of years it takes to build up high nucleotide diversity.
650	7	a Natural Sciences2 hsv
650	7	a Biological Sciences2 hsv
650	7	a Naturvetenskap2 hsv0 264446
650	7	a Biologiska vetenskaper2 hsv
700	1	a Pettersson, Mats4 aut
700	1	a Lamichhaney, Sangeet4 aut
700	1	a Rubin, Carl-Johan4 aut
700	1	a Rafati, Nima4 aut
700	1	a Casini, Michele4 aut
700	1	a Folkvord, Arild4 aut
700	1	a Andersson, Leif4 aut
710	1 2	a Uppsala universitetb Science for Life Laboratory, SciLifeLab4 pbl
710	1 2	a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl
772	1 8	i channel recordw 19753896
773	0 8	i Värdpublikationt eLIFEg 6
856	4 0	u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-333409
856	4 0	u http://dx.doi.org/10.7554/eLife.23907
856	4 0	u http://uu.diva-portal.org/smash/get/diva2:1157153/FULLTEXT01
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950	k	6 650a Matematikw hu Naturvetenskap
950	k	6 650a Medicinska experimentw hu Naturvetenskap
950	k	6 650a Tyngdlagenw hu Naturvetenskap
950	k	6 650a Utvecklingsläraw hu Naturvetenskap
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852		5 APISb APIS
856	4 0	5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-333409

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Av författaren/redakt...: Feng, Chungang; Pettersson, Mats; Lamichhaney, San ...; Rubin, Carl-Joha ...; Rafati, Nima; Casini, Michele; visa fler...; Folkvord, Arild; Andersson, Leif; visa färre...

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