Genome-wide association study identifies multiple risk loci for renal cell carcinoma

doi:10.1038/ncomms15724

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Fältnamn	Indikatorer	Metadata
000		07299naa a22019093a 4500
001		20879839
003		SE-LIBR
005		20170629204434.0
007		cr\|\|\|\|\|\|\|\|\|\|\|\|
008		170629s2017 sw \|\|\|\| o \|\|\|\| \|\|eng c
024	7	a http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1370382 uri
024	7	a urn:nbn:se:umu:diva-1370382 urn
024	7	a 10.1038/ncomms157242 doi
040		a S
041	0	a eng
042		9 EPLK
100	1	a Scelo, Ghislaine4 aut
245	1 0	a Genome-wide association study identifies multiple risk loci for renal cell carcinomah [Elektronisk resurs]
260		b NATURE PUBLISHING GROUPc 2017
500		a Published
506	0	a gratis
520		a Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P = 3.1 x 10(-10)), 3p22.1 (rs67311347, P = 2.5 x 10(-8)), 3q26.2 (rs10936602, P = 8.8 x 10(-9)), 8p21.3 (rs2241261, P = 5.8 x 10(-9)), 10q24.33-q25.1 (rs11813268, P = 3.9 x 10(-8)), 11q22.3 (rs74911261, P = 2.1 x 10(-10)) and 14q24.2 (rs4903064, P = 2.2 x 10(-24)). Expression quantitative trait analyses suggest plausible candidate genes at these regions that may contribute to RCC susceptibility.
650	7	a Medical and Health Sciences2 hsv
650	7	a Clinical Medicine2 hsv
650	7	a Urology and Nephrology2 hsv
650	7	a Medicin och hälsovetenskap2 hsv
650	7	a Klinisk medicin2 hsv
650	7	a Urologi och njurmedicin2 hsv
700	1	a Purdue, Mark P.4 aut
700	1	a Brown, Kevin M.4 aut
700	1	a Johansson, Mattias4 aut
700	1	a Wang, Zhaoming4 aut
700	1	a Eckel-Passow, Jeanette E.4 aut
700	1	a Ye, Yuanqing4 aut
700	1	a Hofmann, Jonathan N.4 aut
700	1	a Choi, Jiyeon4 aut
700	1	a Foll, Matthieu4 aut
700	1	a Gaborieau, Valerie4 aut
700	1	a Machiela, Mitchell J.4 aut
700	1	a Colli, Leandro M.4 aut
700	1	a Li, Peng4 aut
700	1	a Sampson, Joshua N.4 aut
700	1	a Abedi-Ardekani, Behnoush4 aut
700	1	a Besse, Celine4 aut
700	1	a Blanche, Helene4 aut
700	1	a Boland, Anne4 aut
700	1	a Burdette, Laurie4 aut
700	1	a Chabrier, Amelie4 aut
700	1	a Durand, Geoffroy4 aut
700	1	a Le Calvez-Kelm, Florence4 aut
700	1	a Prokhortchouk, Egor4 aut
700	1	a Robinot, Nivonirina4 aut
700	1	a Skryabin, Konstantin G.4 aut
700	1	a Wozniak, Magdalena B.4 aut
700	1	a Yeager, Meredith4 aut
700	1	a Basta-Jovanovic, Gordana4 aut
700	1	a Dzamic, Zoran4 aut
700	1	a Foretova, Lenka4 aut
700	1	a Holcatova, Ivana4 aut
700	1	a Janout, Vladimir4 aut
700	1	a Mates, Dana4 aut
700	1	a Mukeriya, Anush4 aut
700	1	a Rascu, Stefan4 aut
700	1	a Zaridze, David4 aut
700	1	a Bencko, Vladimir4 aut
700	1	a Cybulski, Cezary4 aut
700	1	a Fabianova, Eleonora4 aut
700	1	a Jinga, Viorel4 aut
700	1	a Lissowska, Jolanta4 aut
700	1	a Lubinski, Jan4 aut
700	1	a Navratilova, Marie4 aut
700	1	a Rudnai, Peter4 aut
700	1	a Szeszenia-Dabrowska, Neonila4 aut
700	1	a Benhamou, Simone4 aut
700	1	a Cancel-Tassin, Geraldine4 aut
700	1	a Cussenot, Olivier4 aut
700	1	a Baglietto, Laura4 aut
700	1	a Boeing, Heiner4 aut
700	1	a Khaw, Kay-Tee4 aut
700	1	a Weiderpass, Elisabete4 aut
700	1	a Ljungberg, Börje4 aut
700	1	a Sitaram, Raviprakash T.4 aut
700	1	a Bruinsma, Fiona4 aut
700	1	a Jordan, Susan J.4 aut
700	1	a Severi, Gianluca4 aut
700	1	a Winship, Ingrid4 aut
700	1	a Hveem, Kristian4 aut
700	1	a Vatten, Lars J.4 aut
700	1	a Fletcher, Tony4 aut
700	1	a Koppova, Kvetoslava4 aut
700	1	a Larsson, Susanna C.4 aut
700	1	a Wolk, Alicja4 aut
700	1	a Banks, Rosamonde E.4 aut
700	1	a Selby, Peter J.4 aut
700	1	a Easton, Douglas F.4 aut
700	1	a Pharoah, Paul4 aut
700	1	a Andreotti, Gabriella4 aut
700	1	a Freeman, Laura E. Beane4 aut
700	1	a Koutros, Stella4 aut
700	1	a Albanes, Demetrius4 aut
700	1	a Mannisto, Satu4 aut
700	1	a Weinstein, Stephanie4 aut
700	1	a Clark, Peter E.4 aut
700	1	a Edwards, Todd L.4 aut
700	1	a Lipworth, Loren4 aut
700	1	a Gapstur, Susan M.4 aut
700	1	a Stevens, Victoria L.4 aut
700	1	a Carol, Hallie4 aut
700	1	a Freedman, Matthew L.4 aut
700	1	a Pomerantz, Mark M.4 aut
700	1	a Cho, Eunyoung4 aut
700	1	a Kraft, Peter4 aut
700	1	a Preston, Mark A.4 aut
700	1	a Wilson, Kathryn M.4 aut
700	1	a Gaziano, J. Michael4 aut
700	1	a Sesso, Howard D.4 aut
700	1	a Black, Amanda4 aut
700	1	a Freedman, Neal D.4 aut
700	1	a Huang, Wen-Yi4 aut
700	1	a Anema, John G.4 aut
700	1	a Kahnoski, Richard J.4 aut
700	1	a Lane, Brian R.4 aut
700	1	a Noyes, Sabrina L.4 aut
700	1	a Petillo, David4 aut
700	1	a Teh, Bin Tean4 aut
700	1	a Peters, Ulrike4 aut
700	1	a White, Emily4 aut
700	1	a Anderson, Garnet L.4 aut
700	1	a Johnson, Lisa4 aut
700	1	a Luo, Juhua4 aut
700	1	a Buring, Julie4 aut
700	1	a Lee, I-Min4 aut
700	1	a Chow, Wong-Ho4 aut
700	1	a Moore, Lee E.4 aut
700	1	a Wood, Christopher4 aut
700	1	a Eisen, Timothy4 aut
700	1	a Henrion, Marc4 aut
700	1	a Larkin, James4 aut
700	1	a Barman, Poulami4 aut
700	1	a Leibovich, Bradley C.4 aut
700	1	a Choueiri, Toni K.4 aut
700	1	a Lathrop, G. Mark4 aut
700	1	a Rothman, Nathaniel4 aut
700	1	a Deleuze, Jean-Francois4 aut
700	1	a Mckay, James D.4 aut
700	1	a Parker, Alexander S.4 aut
700	1	a Wu, Xifeng4 aut
700	1	a Houlston, Richard S.4 aut
700	1	a Brennan, Paul4 aut
700	1	a Chanock, Stephen J.4 aut
710	1 2	a Umeå universitetb Medicinska fakulteten4 pbl0 268483
772	1 8	i channel recordw 18813935
773	0 8	i Värdpublikationt Nature Communicationsg 8x 2041-1723
856	4 0	u http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-137038
856	4 0	u http://dx.doi.org/10.1038/ncomms15724
856	4 0	u http://umu.diva-portal.org/smash/get/diva2:1117165/FULLTEXT01
910	2 s	6 710a Umeå universitet.b Medicinsk-odontologiska fakultetenu Umeå universitet.b Medicinska fakulteten
910	2 s	6 710a Medicinska fakulteten vid Umeå universitetu Umeå universitet.b Medicinska fakulteten
841		5 APISa x ab 170629\|\|0000\|\|\|\|\|001\|\|\|\|\|\|000000e 1
024	7	5 APISa urn:nbn:se:umu:diva-1370382 urn
852		5 APISb APIS
856	4 0	5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-137038

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Av författaren/redakt...: Scelo, Ghislaine; Purdue, Mark P.; Brown, Kevin M.; Johansson, Matti ...; Wang, Zhaoming; Eckel-Passow, Je ...; visa fler...; Ye, Yuanqing; Hofmann, Jonatha ...; Choi, Jiyeon; Foll, Matthieu; Gaborieau, Valer ...; Machiela, Mitche ...; Colli, Leandro M ...; Li, Peng; Sampson, Joshua ...; Abedi-Ardekani, ...; Besse, Celine; Blanche, Helene; Boland, Anne; Burdette, Laurie; Chabrier, Amelie; Durand, Geoffroy; Le Calvez-Kelm, ...; Prokhortchouk, E ...; Robinot, Nivonir ...; Skryabin, Konsta ...; Wozniak, Magdale ...; Yeager, Meredith; Basta-Jovanovic, ...; Dzamic, Zoran; Foretova, Lenka; Holcatova, Ivana; Janout, Vladimir; Mates, Dana; Mukeriya, Anush; Rascu, Stefan; Zaridze, David; Bencko, Vladimir; Cybulski, Cezary; Fabianova, Eleon ...; Jinga, Viorel; Lissowska, Jolan ...; Lubinski, Jan; Navratilova, Mar ...; Rudnai, Peter; Szeszenia-Dabrow ...; Benhamou, Simone; Cancel-Tassin, G ...; Cussenot, Olivie ...; Baglietto, Laura; Boeing, Heiner; Khaw, Kay-Tee; Weiderpass, Elis ...; Ljungberg, Börje; Sitaram, Ravipra ...; Bruinsma, Fiona; Jordan, Susan J.; Severi, Gianluca; Winship, Ingrid; Hveem, Kristian; Vatten, Lars J.; Fletcher, Tony; Koppova, Kvetosl ...; Larsson, Susanna ...; Wolk, Alicja; Banks, Rosamonde ...; Selby, Peter J.; Easton, Douglas ...; Pharoah, Paul; Andreotti, Gabri ...; Freeman, Laura E ...; Koutros, Stella; Albanes, Demetri ...; Mannisto, Satu; Weinstein, Steph ...; Clark, Peter E.; Edwards, Todd L.; Lipworth, Loren; Gapstur, Susan M ...; Stevens, Victori ...; Carol, Hallie; Freedman, Matthe ...; Pomerantz, Mark ...; Cho, Eunyoung; Kraft, Peter; Preston, Mark A.; Wilson, Kathryn ...; Gaziano, J. Mich ...; Sesso, Howard D.; Black, Amanda; Freedman, Neal D ...; Huang, Wen-Yi; Anema, John G.; Kahnoski, Richar ...; Lane, Brian R.; Noyes, Sabrina L ...; Petillo, David; Teh, Bin Tean; Peters, Ulrike; White, Emily; Anderson, Garnet ...; Johnson, Lisa; Luo, Juhua; Buring, Julie; Lee, I-Min; Chow, Wong-Ho; Moore, Lee E.; Wood, Christophe ...; Eisen, Timothy; Henrion, Marc; Larkin, James; Barman, Poulami; Leibovich, Bradl ...; Choueiri, Toni K ...; Lathrop, G. Mark; Rothman, Nathani ...; Deleuze, Jean-Fr ...; Mckay, James D.; Parker, Alexande ...; Wu, Xifeng; Houlston, Richar ...; Brennan, Paul; Chanock, Stephen ...; visa färre...

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