Meta-Analysis of Genome-Wide Association Studies Identifies Six New Loci for Serum Calcium Concentrations

doi:10.1371/journal.pgen.1003796

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Maerz Winfried) > Meta-Analysis of Ge...

LIBRIS Formathandbok (Information om MARC21)

Fältnamn	Indikatorer	Metadata
000		06605naa a22016693a 4500
001		22081010
003		SE-LIBR
005		20171207151605.0
007		cr\|\|\|\|\|\|\|\|\|\|\|\|
008		171207s2013 sw \|\|\|\| o \|\|\|\| \|\|eng c
024	7	a http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2102562 uri
024	7	a urn:nbn:se:uu:diva-2102562 urn
024	7	a 10.1371/journal.pgen.10037962 doi
040		a S
041	0	a eng
042		9 EPLK
100	1	a O'Seaghdha, Conall M.4 aut
245	1 0	a Meta-Analysis of Genome-Wide Association Studies Identifies Six New Loci for Serum Calcium Concentrationsh [Elektronisk resurs]
260		c 2013
500		a Published
506	0	a gratis
520		a Calcium is vital to the normal functioning of multiple organ systems and its serum concentration is tightly regulated. Apart from CASR, the genes associated with serum calcium are largely unknown. We conducted a genome-wide association meta-analysis of 39,400 individuals from 17 population-based cohorts and investigated the 14 most strongly associated loci in <= 21,679 additional individuals. Seven loci (six new regions) in association with serum calcium were identified and replicated. Rs1570669 near CYP24A1 (P = 9.1E-12), rs10491003 upstream of GATA3 (P = 4.8E-09) and rs7481584 in CARS (P = 1.2E-10) implicate regions involved in Mendelian calcemic disorders: Rs1550532 in DGKD (P = 8.2E-11), also associated with bone density, and rs7336933 near DGKH/KIAA0564 (P = 9.1E-10) are near genes that encode distinct isoforms of diacylglycerol kinase. Rs780094 is in GCKR. We characterized the expression of these genes in gut, kidney, and bone, and demonstrate modulation of gene expression in bone in response to dietary calcium in mice. Our results shed new light on the genetics of calcium homeostasis.
650	7	a Medical and Health Sciences2 hsv
650	7	a Medicin och hälsovetenskap2 hsv
700	1	a Wu, Hongsheng4 aut
700	1	a Yang, Qiong4 aut
700	1	a Kapur, Karen4 aut
700	1	a Guessous, Idris4 aut
700	1	a Zuber, Annie Mercier4 aut
700	1	a Koettgen, Anna4 aut
700	1	a Stoudmann, Candice4 aut
700	1	a Teumer, Alexander4 aut
700	1	a Kutalik, Zoltan4 aut
700	1	a Mangino, Massimo4 aut
700	1	a Dehghan, Abbas4 aut
700	1	a Zhang, Weihua4 aut
700	1	a Eiriksdottir, Gudny4 aut
700	1	a Li, Guo4 aut
700	1	a Tanaka, Toshiko4 aut
700	1	a Portas, Laura4 aut
700	1	a Lopez, Lorna M.4 aut
700	1	a Hayward, Caroline4 aut
700	1	a Lohman, Kurt4 aut
700	1	a Matsuda, Koichi4 aut
700	1	a Padmanabhan, Sandosh4 aut
700	1	a Firsov, Dmitri4 aut
700	1	a Sorice, Rossella4 aut
700	1	a Ulivi, Sheila4 aut
700	1	a Brockhaus, A. Catharina4 aut
700	1	a Kleber, Marcus E.4 aut
700	1	a Mahajan, Anubha4 aut
700	1	a Ernst, Florian D.4 aut
700	1	a Gudnason, Vilmundur4 aut
700	1	a Launer, Lenore J.4 aut
700	1	a Mace, Aurelien4 aut
700	1	a Boerwinckle, Eric4 aut
700	1	a Arking, Dan E.4 aut
700	1	a Tanikawa, Chizu4 aut
700	1	a Nakamura, Yusuke4 aut
700	1	a Brown, Morris J.4 aut
700	1	a Gaspoz, Jean-Michel4 aut
700	1	a Theler, Jean-Marc4 aut
700	1	a Siscovick, David S.4 aut
700	1	a Psaty, Bruce M.4 aut
700	1	a Bergmann, Sven4 aut
700	1	a Vollenweider, Peter4 aut
700	1	a Vitart, Veronique4 aut
700	1	a Wright, Alan F.4 aut
700	1	a Zemunik, Tatijana4 aut
700	1	a Boban, Mladen4 aut
700	1	a Kolcic, Ivana4 aut
700	1	a Navarro, Pau4 aut
700	1	a Brown, Edward M.4 aut
700	1	a Estrada, Karol4 aut
700	1	a Ding, Jingzhong4 aut
700	1	a Harris, Tamara B.4 aut
700	1	a Bandinelli, Stefania4 aut
700	1	a Hernandez, Dena4 aut
700	1	a Singleton, Andrew B.4 aut
700	1	a Girotto, Giorgia4 aut
700	1	a Ruggiero, Daniela4 aut
700	1	a d'Adamo, Adamo Pio4 aut
700	1	a Robino, Antonietta4 aut
700	1	a Meitinger, Thomas4 aut
700	1	a Meisinger, Christa4 aut
700	1	a Davies, Gail4 aut
700	1	a Starr, John M.4 aut
700	1	a Chambers, John C.4 aut
700	1	a Boehm, Bernhard O.4 aut
700	1	a Winkelmann, Bernhard R.4 aut
700	1	a Huang, Jie4 aut
700	1	a Murgia, Federico4 aut
700	1	a Wild, Sarah H.4 aut
700	1	a Campbell, Harry4 aut
700	1	a Morris, Andrew P.4 aut
700	1	a Franco, Oscar H.4 aut
700	1	a Hofman, Albert4 aut
700	1	a Uitterlinden, Andre G.4 aut
700	1	a Rivadeneira, Fernando4 aut
700	1	a Voelker, Uwe4 aut
700	1	a Hannemann, Anke4 aut
700	1	a Biffar, Reiner4 aut
700	1	a Hoffmann, Wolfgang4 aut
700	1	a Shin, So-Youn4 aut
700	1	a Lescuyer, Pierre4 aut
700	1	a Henry, Hughes4 aut
700	1	a Schurmann, Claudia4 aut
700	1	a Munroe, Patricia B.4 aut
700	1	a Gasparini, Paolo4 aut
700	1	a Pirastu, Nicola4 aut
700	1	a Ciullo, Marina4 aut
700	1	a Gieger, Christian4 aut
700	1	a Maerz, Winfried4 aut
700	1	a Lind, Lars4 aut
700	1	a Spector, Tim D.4 aut
700	1	a Smith, Albert V.4 aut
700	1	a Rudan, Igor4 aut
700	1	a Wilson, James F.4 aut
700	1	a Polasek, Ozren4 aut
700	1	a Deary, Ian J.4 aut
700	1	a Pirastu, Mario4 aut
700	1	a Ferrucci, Luigi4 aut
700	1	a Liu, Yongmei4 aut
700	1	a Kestenbaum, Bryan4 aut
700	1	a Kooner, Jaspal S.4 aut
700	1	a Witteman, Jacqueline C. M.4 aut
700	1	a Nauck, Matthias4 aut
700	1	a Kao, W. H. Linda4 aut
700	1	a Wallaschofski, Henri4 aut
700	1	a Bonny, Olivier4 aut
700	1	a Fox, Caroline S.4 aut
700	1	a Bochud, Murielle4 aut
710	1 2	a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl
772	1 8	i channel recordw 19753896
773	0 8	i Värdpublikationt PLOS Geneticsg 9:9, e1003796x 1553-7390
856	4 0	u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-210256
856	4 0	u http://dx.doi.org/10.1371/journal.pgen.1003796
856	4 0	u http://uu.diva-portal.org/smash/get/diva2:661889/FULLTEXT01
841		5 APISa x ab 171207\|\|0000\|\|\|\|\|001\|\|\|\|\|\|000000e 1
024	7	5 APISa urn:nbn:se:uu:diva-2102562 urn
852		5 APISb APIS
856	4 0	5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-210256

Hitta via bibliotek

PLOS Genetics (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: O'Seaghdha, Cona ...; Wu, Hongsheng; Yang, Qiong; Kapur, Karen; Guessous, Idris; Zuber, Annie Mer ...; visa fler...; Koettgen, Anna; Stoudmann, Candi ...; Teumer, Alexande ...; Kutalik, Zoltan; Mangino, Massimo; Dehghan, Abbas; Zhang, Weihua; Eiriksdottir, Gu ...; Li, Guo; Tanaka, Toshiko; Portas, Laura; Lopez, Lorna M.; Hayward, Carolin ...; Lohman, Kurt; Matsuda, Koichi; Padmanabhan, San ...; Firsov, Dmitri; Sorice, Rossella; Ulivi, Sheila; Brockhaus, A. Ca ...; Kleber, Marcus E ...; Mahajan, Anubha; Ernst, Florian D ...; Gudnason, Vilmun ...; Launer, Lenore J ...; Mace, Aurelien; Boerwinckle, Eri ...; Arking, Dan E.; Tanikawa, Chizu; Nakamura, Yusuke; Brown, Morris J.; Gaspoz, Jean-Mic ...; Theler, Jean-Mar ...; Siscovick, David ...; Psaty, Bruce M.; Bergmann, Sven; Vollenweider, Pe ...; Vitart, Veroniqu ...; Wright, Alan F.; Zemunik, Tatijan ...; Boban, Mladen; Kolcic, Ivana; Navarro, Pau; Brown, Edward M.; Estrada, Karol; Ding, Jingzhong; Harris, Tamara B ...; Bandinelli, Stef ...; Hernandez, Dena; Singleton, Andre ...; Girotto, Giorgia; Ruggiero, Daniel ...; d'Adamo, Adamo P ...; Robino, Antoniet ...; Meitinger, Thoma ...; Meisinger, Chris ...; Davies, Gail; Starr, John M.; Chambers, John C ...; Boehm, Bernhard ...; Winkelmann, Bern ...; Huang, Jie; Murgia, Federico; Wild, Sarah H.; Campbell, Harry; Morris, Andrew P ...; Franco, Oscar H.; Hofman, Albert; Uitterlinden, An ...; Rivadeneira, Fer ...; Voelker, Uwe; Hannemann, Anke; Biffar, Reiner; Hoffmann, Wolfga ...; Shin, So-Youn; Lescuyer, Pierre; Henry, Hughes; Schurmann, Claud ...; Munroe, Patricia ...; Gasparini, Paolo; Pirastu, Nicola; Ciullo, Marina; Gieger, Christia ...; Maerz, Winfried; Lind, Lars; Spector, Tim D.; Smith, Albert V.; Rudan, Igor; Wilson, James F.; Polasek, Ozren; Deary, Ian J.; Pirastu, Mario; Ferrucci, Luigi; Liu, Yongmei; Kestenbaum, Brya ...; Kooner, Jaspal S ...; Witteman, Jacque ...; Nauck, Matthias; Kao, W. H. Linda; Wallaschofski, H ...; Bonny, Olivier; Fox, Caroline S.; Bochud, Murielle; visa färre...

Av lärosätet: Swepub_uni:_t

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se