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Smokeless tobacco (...
Smokeless tobacco (snus) and risk of heart failure : results from two Swedish cohorts
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- Arefalk, Gabriel (author)
- Uppsala universitet,Kardiovaskulär epidemiologi,Akut- och internmedicin
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Hergens, Maria-Pia (author)
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- Ingelsson, Erik (author)
- Uppsala universitet,Geriatrik
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- Ärnlöv, Johan (author)
- Uppsala universitet,Högskolan Dalarna,Medicinsk vetenskap,Geriatrik
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- Michaëlsson, Karl (author)
- Uppsala universitet,Ortopedi
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- Lind, Lars (author)
- Uppsala universitet,Kardiovaskulär epidemiologi,Akut- och internmedicin
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- Ye, Weimin (author)
- Karolinska Institutet
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Nyrén, Olof (author)
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- Lambe, Mats (author)
- Karolinska Institutet
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- Sundström, Johan (author)
- Uppsala universitet,Kardiovaskulär epidemiologi,Akut- och internmedicin
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(creator_code:org_t)
- 2011-08-09
- 2012
- English.
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In: European Journal of Cardiovascular Prevention & Rehabilitation. - : Sage Publications. - 1741-8267 .- 1741-8275 .- 2047-4873 .- 2047-4881. ; 19:5, s. 1120-1127
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: Oral moist snuff (snus) is discussed as a safer alternative to smoking, and its use is increasing. Based on its documented effect on blood pressure, we hypothesized that use of snus increases the risk of heart failure.Design: Two independent Swedish prospective cohorts; the Uppsala Longitudinal Study of Adult Men (ULSAM), a community-based sample of 1076 elderly men, and the Construction Workers Cohort (CWC), a sample of 118,425 never-smoking male construction workers. Methods: Cox proportional hazards models were used to investigate possible associations of snus use with risk of a first hospitalization for heart failure.Results: In ULSAM, 95 men were hospitalized for heart failure, during a median follow up of 8.9 years. In a model adjusted for established risk factors including past and present smoking exposure, current snus use was associated with a higher risk of heart failure [hazard ratio (HR) 2.08, 95% confidence interval (CI) 1.03-4.22] relative to non-use. Snus use was particularly associated with risk of non-ischaemic heart failure (HR 2.55, 95% CI 1.12-5.82). In CWC, 545 men were hospitalized for heart failure, during a median follow up of 18 years. In multivariable-adjusted models, current snus use was moderately associated with a higher risk of heart failure (HR 1.28, 95% CI 1.00-1.64) and non-ischaemic heart failure (HR 1.28, 95% CI 0.97-1.68) relative to never tobacco use.Conclusion: Data from two independent cohorts suggest that use of snus may be associated with a higher risk of heart failure.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Keyword
- Epidemiology
- heart failure
- risk factors
- smokeless tobacco
- snus
- Hälsa och välfärd
- Health and Welfare
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Arefalk, Gabriel
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Hergens, Maria-P ...
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Ingelsson, Erik
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Ärnlöv, Johan
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Michaëlsson, Kar ...
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Lind, Lars
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show more...
-
Ye, Weimin
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Nyrén, Olof
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Lambe, Mats
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Sundström, Johan
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
- Articles in the publication
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European Journal ...
- By the university
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Högskolan Dalarna
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Uppsala University
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Karolinska Institutet