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Serum cathepsin S i...
Serum cathepsin S is associated with decreased insulin sensitivity and the development of diabetes type 2 in a community-based cohort of elderly men
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- Jobs, Elisabeth (author)
- Uppsala universitet,Högskolan Dalarna,Medicinsk vetenskap,Geriatrik
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- Risérus, Ulf (author)
- Uppsala universitet,Klinisk nutrition och metabolism
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- Ingelsson, Erik (author)
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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- Sundström, Johan (author)
- Uppsala universitet,Kardiologi
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- Jobs, Magnus (author)
- Högskolan Dalarna,Medicinsk vetenskap,University of Dalarna
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- Nerpin, Elisabet (author)
- Uppsala universitet,Högskolan Dalarna,Medicinsk vetenskap,Geriatrik
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- Iggman, David (author)
- Uppsala universitet,Klinisk nutrition och metabolism
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- Basu, Samar (author)
- Uppsala universitet,Oxidativ stress och inflammation
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- Larsson, Anders (author)
- Uppsala universitet,Biokemisk struktur och funktion
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- Lars, Lind (author)
- Uppsala universitet,Kardiovaskulär epidemiologi
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- Ärnlöv, Johan (author)
- Uppsala universitet,Högskolan Dalarna,Medicinsk vetenskap,Geriatrik
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(creator_code:org_t)
- 2012-12-11
- 2012
- English.
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In: Diabetes Care. - : American diabetes association. - 0149-5992 .- 1935-5548. ; 36:1, s. 163-165
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.2...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- OBJECTIVE. To investigate associations between serum cathepsin S, impaired insulin sensitivity, defective insulin secretion, and diabetes risk in a community-based sample of elderly men without diabetes.RESEARCH DESIGN AND METHODS. Serum cathepsin S, insulin sensitivity (euglycaemic-hyperinsulinaemic clamp), and insulin secretion (early insulin response during an oral glucose tolerance test) were measured in 905 participants of the Uppsala Longitudinal Study of Adult Men (mean age, 71 years). Thirty participants developed diabetes during 6 years of follow-up.RESULTS. After adjustment for age, anthropometric variables, and inflammatory markers, higher cathepsin S was associated with decreased insulin sensitivity (regression coefficient per SD increase -0.09 [95% CI -0.14 to -0.04], P = 0.001), but no association with early insulin response was found. Moreover, higher cathepsin S was associated with a higher risk for developing diabetes (odds ratio per SD increase 1.48 [1.08-2.01], P = 0.01).CONCLUSIONS. Cathepsin S activity appears to be involved in the early dysregulation of glucose and insulin metabolism.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Hälsa och välfärd
- Health and Welfare
- Cathepsin S inflammation adipose tissue insulin resistance diabetes
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Jobs, Elisabeth
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Risérus, Ulf
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Ingelsson, Erik
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Sundström, Johan
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Jobs, Magnus
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Nerpin, Elisabet
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show more...
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Iggman, David
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Basu, Samar
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Larsson, Anders
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Lars, Lind
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Ärnlöv, Johan
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Diabetes Care
- By the university
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Högskolan Dalarna
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Uppsala University